Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene-Derived Cyclohexenyl Chalcones

2018 ◽  
Vol 2018 (42) ◽  
pp. 5830-5835 ◽  
Author(s):  
Shelly Gapil Tiamas ◽  
Florian Audet ◽  
Alma Abou Samra ◽  
Jérome Bignon ◽  
Marc Litaudon ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Asymmetric Total Synthesis ◽  
Synthesis And Biological Evaluation

Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone

2020 ◽  
Vol 22 (2) ◽  
pp. 584-588 ◽  
Author(s):  
Ke-Qiang Hou ◽  
Xue-Ping Chen ◽  
Yiyou Huang ◽  
Albert S. C. Chan ◽  
Hai-Bin Luo ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Pde4 Inhibitor ◽  
Asymmetric Total Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Asymmetric Total Synthesis and Biological Evaluation of (+)-Cycloclavine

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 213-224 ◽  
Author(s):  
Stephanie McCabe ◽  
Peter Wipf
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Diels Alder ◽  
Asymmetric Total Synthesis ◽  
Binding Properties ◽  
Asymmetric Cyclopropanation ◽  
Synthesis And Biological Evaluation

The first total synthesis of natural (+)-cycloclavine uses a catalytic­ asymmetric cyclopropanation of allene, a regiospecific Pd-catalyzed­ enone formation, and two intramolecular Diels–Alder reactions for indole/indoline annulations. The binding properties of natural (+)- and unnatural (–)-cycloclavine on 16 CNS receptors revealed significant stereospecificity and unique binding profiles in comparison to LSD, psilocin, and DMT. Differential 5-HT affinities, as well as novel sigma­-1 receptor properties bode well for potential therapeutic developments of clavine alkaloid scaffolds.

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

Total synthesis and biological evaluation of Wewakazole

2017 ◽  
Vol 33 (6) ◽  
pp. 890-894 ◽  
Author(s):  
Bohua Long ◽  
Jingzhao Zhang ◽  
Xueyan Wang ◽  
Xudong Tang ◽  
Zhengzhi Wu
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof

2009 ◽  
Vol 131 (30) ◽  
pp. 10587-10597 ◽  
Author(s):  
K. C. Nicolaou ◽  
Xiao-Shui Peng ◽  
Ya-Ping Sun ◽  
Damien Polet ◽  
Bin Zou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

2018 ◽  
Vol 57 (34) ◽  
pp. 11020-11024 ◽  
Author(s):  
Hiromu Hattori ◽  
Joel Roesslein ◽  
Patrick Caspers ◽  
Katja Zerbe ◽  
Hideki Miyatake-Ondozabal ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Macrocyclic Antibiotic ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues

2009 ◽  
Vol 15 (46) ◽  
pp. 12807-12818 ◽  
Author(s):  
Haruhiko Fuwa ◽  
Asami Saito ◽  
Shinya Naito ◽  
Keiichi Konoki ◽  
Mari Yotsu-Yamashita ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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