scholarly journals Nucleoside Analogues: Synthesis and Biological Properties of Azanucleoside Derivatives (Eur. J. Org. Chem. 11/2014)

2014 ◽  
Vol 2014 (11) ◽  
pp. n/a-n/a
Author(s):  
Dácil Hernández ◽  
Alicia Boto
Keyword(s):  
Biological Properties ◽  
Nucleoside Analogues

New nucleoside analogues and their 5′-triphosphates: Synthesis and biological properties

2008 ◽  
Vol 63 (2) ◽  
pp. 89-93 ◽  
Author(s):  
N. A. Golubeva ◽  
A. V. Ivanov ◽  
M. A. Ivanov ◽  
O. A. Batyunina ◽  
A. V. Shipitsyn ◽  
...  
Keyword(s):  
Biological Properties ◽  
Nucleoside Analogues

ChemInform Abstract: Highly Stereoselective Synthesis and Biological Properties of Nucleoside Analogues Bearing a Spiro Inserted Oxirane Ring.

ChemInform ◽  
2000 ◽  
Vol 31 (44) ◽  
pp. no-no
Author(s):  
Jean M. J. Tronchet ◽  
Imre Kovacs ◽  
Michel Seman ◽  
Pierre Dilda ◽  
Erik De Clercq ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Biological Properties ◽  
Oxirane Ring ◽  
Nucleoside Analogues

Highly Stereoselective Synthesis and Biological Properties of Nucleoside Analogues Bearing a Spiro Inserted Oxirane Ring

2000 ◽  
Vol 19 (4) ◽  
pp. 775-794 ◽  
Author(s):  
Jean M. J. Tronchet ◽  
Imre Kovacs ◽  
Michel Seman ◽  
Pierre Dilda ◽  
Erik De Clercq ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Biological Properties ◽  
Oxirane Ring ◽  
Nucleoside Analogues

scholarly journals Carbocyclodipeptides as modified nucleosides: synthesis and anti-HIV activities

2014 ◽  
Vol 92 (12) ◽  
pp. 1145-1149
Author(s):  
Bhupender S. Chhikara ◽  
M. Sudershan Rao ◽  
V. Kameshwara Rao ◽  
Anil Kumar ◽  
Karen W. Buckheit ◽  
...  
Keyword(s):  
High Resolution ◽  
Biological Properties ◽  
Modified Nucleosides ◽  
Nucleoside Analogues ◽  
Cyclic Dipeptides ◽  
New Class ◽  
Anti Hiv ◽  
Ribose Sugar

A new class of nucleoside analogues were synthesized using cyclic dipeptides and modified 2′-deoxyfuranoribose sugars to introduce flexibility by peptides in place of common nucleoside bases and to determine their biological properties. The synthesis was carried out by coupling of a protected ribose sugar with synthesized dipeptides in the presence of hexamethyldisilazane and trimethylsilyltriflate. The final products were characterized by NMR and high-resolution MS-TOF spectroscopy. The compounds were evaluated for anti-HIV activities. 1-(4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6-diisopropylpiperazine-2,5-dione (compound 14) containing 3- and 6-isopropyl groups in the base and 3′-azide (EC50 = 1.96 μmol/L) was the most potent compound among all of the synthesized analogs.

Sign in / Sign up

Export Citation Format

Share Document