Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C-N Bond Cleavage

2014 ◽  
Vol 2014 (20) ◽  
pp. 4244-4247 ◽  
Author(s):  
Biquan Xiong ◽  
Longzhi Zhu ◽  
Xiaofeng Feng ◽  
Jian Lei ◽  
Tieqiao Chen ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Bond Cleavage ◽  
Copper Catalysts ◽  
Tertiary Amines ◽  
Amide Formation ◽  
Direct Amidation

ChemInform Abstract: Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts Through C-N Bond Cleavage.

ChemInform ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. no-no
Author(s):  
Biquan Xiong ◽  
Longzhi Zhu ◽  
Xiaofeng Feng ◽  
Jian Lei ◽  
Tieqiao Chen ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Bond Cleavage ◽  
Copper Catalysts ◽  
Tertiary Amines ◽  
Amide Formation ◽  
Direct Amidation

scholarly journals Silicon compounds as stoichiometric coupling reagents for direct amidation

2021 ◽  
Author(s):  
Joshua J. Davies ◽  
D. Christopher Braddock ◽  
Paul D. Lickiss
Keyword(s):  
Carboxylic Acids ◽  
Coupling Reagents ◽  
Silicon Compounds ◽  
Direct Amidation

This review covers all the reported use of stoichiometric silicon reagents for direct amidation of carboxylic acids with amines, commencing with the first example in 1969 up until April 2021. 

Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

2015 ◽  
Vol 17 (5) ◽  
pp. 3157-3163 ◽  
Author(s):  
Andrea Ojeda-Porras ◽  
Alejandra Hernández-Santana ◽  
Diego Gamba-Sánchez
Keyword(s):  
Fatty Acids ◽  
Microwave Irradiation ◽  
Carboxylic Acids ◽  
Silica Gel ◽  
Solid Support ◽  
Secondary Amines ◽  
Primary And Secondary Amines ◽  
Direct Amidation

A highly improved methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. Several examples using aliphatic, aromatic, unsaturated and fatty acids combined with primary and secondary amines are shown.

ChemInform Abstract: Iodine-Catalyzed C3-Formylation of Indoles via C-N Bond Cleavage of Tertiary Amines under Aerobic Conditions.

ChemInform ◽  
2015 ◽  
Vol 46 (37) ◽  
pp. no-no
Author(s):  
Lin Lu ◽  
Qiheng Xiong ◽  
Shengmei Guo ◽  
Tianqiang He ◽  
Feng Xu ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Tertiary Amines ◽  
Aerobic Conditions

Pd/C-catalyzed synthesis of oxamates by oxidative cross double carbonylation of alcohols and tertiary amines through C–N bond cleavage

2019 ◽  
Vol 43 (46) ◽  
pp. 18072-18078 ◽  
Author(s):  
Yuvraj A. Kolekar ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Active Compound ◽  
Bond Cleavage ◽  
Tertiary Amines ◽  
Carbonylation Reaction ◽  
Palladium Catalyzed ◽  
Biological Active Compound

Palladium-catalyzed oxidative cross double carbonylation reaction between tertiary amines and alcohols using oxidant O2 and KI as the additive affords oxamates. Oxamate are as a intermediate in biological active compound and glycol synthesis.

Palladium-catalyzed carbonylative synthesis of arylacetamides from benzyl formates and tertiary amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3406-3410
Author(s):  
Ming Lai ◽  
Zhi-Peng Bao ◽  
Xinxin Qi ◽  
Xiao-Feng Wu
Keyword(s):  
Bond Cleavage ◽  
Tertiary Amines ◽  
Palladium Catalyzed

A palladium-catalyzed carbonylative synthesis of arylacetamides via a C–N bond cleavage of tertiary amines with benzyl formates as the CO source has been disclosed. A variety of arylacetamides were obtained in very good yields under oxidant-free conditions.

A multigram-scale lower E-factor procedure for MIBA-catalyzed direct amidation and its application to the coupling of alpha and beta aminoacids

2015 ◽  
Vol 17 (7) ◽  
pp. 4016-4028 ◽  
Author(s):  
Solmaz Fatemi ◽  
Nicolas Gernigon ◽  
Dennis G. Hall
Keyword(s):  
Amino Acids ◽  
Carboxylic Acids ◽  
Direct Amidation

More economical conditions for direct amidation between amines and carboxylic acids, including α- and β-amino acids, have been optimized using the MIBA catalyst (5-methoxy-2-iodophenylboronic acid, 6).

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