Amide Formation Using In Situ Activation of Carboxylic Acids with [Et2NSF2]BF4

2013 ◽  
Vol 2013 (20) ◽  
pp. 4325-4331 ◽  
Author(s):  
Olivier Mahé ◽  
Justine Desroches ◽  
Jean-François Paquin
Keyword(s):  
Carboxylic Acids ◽  
Amide Formation ◽  
In Situ Activation

ChemInform Abstract: Amide Formation Using in situ Activation of Carboxylic Acids with [Et2NSF2]BF4.

ChemInform ◽  
2013 ◽  
Vol 44 (49) ◽  
pp. no-no
Author(s):  
Olivier Mahe ◽  
Justine Desroches ◽  
Jean-Francois Paquin
Keyword(s):  
Carboxylic Acids ◽  
Amide Formation ◽  
In Situ Activation

An N-Heterocyclic Carbene-Catalyzed Oxidative γ-Aminoalkylation of Saturated Carboxylic Acids through in Situ Activation Strategy: Access to δ-Lactam

2015 ◽  
Vol 17 (24) ◽  
pp. 6234-6237 ◽  
Author(s):  
Yonglei Que ◽  
Yuanwei Xie ◽  
Tuanjie Li ◽  
Chenxia Yu ◽  
Shujiang Tu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
In Situ Activation

An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl-Mediated in situ Activation of α,β-Unsaturated Carboxylic Acids

2016 ◽  
Vol 11 (5) ◽  
pp. 678-681 ◽  
Author(s):  
Yonglei Que ◽  
Yinan Lu ◽  
Wenjing Wang ◽  
Yuhong Wang ◽  
Haotian Wang ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
In Situ Activation ◽  
Unsaturated Carboxylic Acids

ChemInform Abstract: An N-Heterocyclic Carbene-Catalyzed Oxidative γ-Aminoalkylation of Saturated Carboxylic Acids Through in situ Activation Strategy: Access to δ-Lactam.

ChemInform ◽  
2016 ◽  
Vol 47 (19) ◽  
Author(s):  
Yonglei Que ◽  
Yuanwei Xie ◽  
Tuanjie Li ◽  
Chenxia Yu ◽  
Shujiang Tu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
In Situ Activation

An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

2019 ◽  
Vol 17 (18) ◽  
pp. 4564-4571 ◽  
Author(s):  
Zhanlin Wang ◽  
Huiqing Zhang ◽  
Huimin Qian ◽  
Yuanfeng Wang ◽  
Chenxia Yu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
In Situ Activation ◽  
Unsaturated Carboxylic Acids

An N-heterocyclic carbene (NHC)-catalyzed diastereo- and enantioselective α-functionalization of α,β-unsaturated carboxylic acids bearing γ-H to construct dihydrocoumarin was realized through in situ activation.

A Photoactivatable α5β1-Specific Integrin Ligand

2018 ◽  
Author(s):  
Roshna Vakkeel ◽  
Aleeza Farrukh ◽  
Aranzazu del Campo
Keyword(s):  
Cellular Response ◽  
Light Exposure ◽  
Matrix Composition ◽  
Cellular Behavior ◽  
Dynamic Variations ◽  
In Situ Activation ◽  
Controlled Exposure ◽  
Cellular Behaviour ◽  
Integrin Ligand

In order to study how dynamic changes of α5β1 integrin engagement affect cellular behaviour, photoactivatable derivatives of α5β1 specific ligands are presented in this article. The presence of the photoremovable protecting group (PRPG) introduced at a relevant position for integrin recognition, temporally inhibits ligand bioactivity. Light exposure at cell-compatible dose efficiently cleaves the PRPG and restores functionality. Selective cell response (attachment, spreading, migration) to the activated ligand on the surface is achieved upon controlled exposure. Spatial and temporal control of the cellular response is demonstrated, including the possibility to in situ activation. Photoactivatable integrin-selective ligands in model microenvironments will allow the study of cellular behavior in response to changes in the activation of individual integrins as consequence of dynamic variations of matrix composition.

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