Dynamic Kinetic Resolution of β-Amino Esters by a Heterogeneous System of a Palladium Nanocatalyst and Candida antarctica Lipase A (Eur. J. Org. Chem. 10/2011)

2011 ◽  
Vol 2011 (10) ◽  
pp. n/a-n/a
Author(s):  
Karin Engström ◽  
Mozaffar Shakeri ◽  
Jan-E. Bäckvall
Keyword(s):  
Heterogeneous System ◽  
Kinetic Resolution ◽  
Candida Antarctica ◽  
Candida Antarctica Lipase ◽  
Dynamic Kinetic Resolution ◽  
Amino Esters ◽  
Lipase A

ChemInform Abstract: Preparation of Highly Enantiopure β-Amino Esters by Candida antarctica Lipase A.

ChemInform ◽  
2010 ◽  
Vol 32 (31) ◽  
pp. no-no
Author(s):  
Szilvia Gedey ◽  
Arto Liljeblad ◽  
Laszlo Lazar ◽  
Ferenc Fueloep ◽  
Liisa T. Kanerva
Keyword(s):  
Candida Antarctica ◽  
Candida Antarctica Lipase ◽  
Amino Esters ◽  
Lipase A

Preparation of highly enantiopure β-amino esters by Candida antarctica lipase A

2001 ◽  
Vol 12 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Szilvia Gedey ◽  
Arto Liljeblad ◽  
László Lázár ◽  
Ferenc Fülöp ◽  
Liisa T. Kanerva
Keyword(s):  
Candida Antarctica ◽  
Candida Antarctica Lipase ◽  
Amino Esters ◽  
Lipase A

Candida antarctica lipase A—a powerful catalyst for the resolution of heteroaromatic β-amino esters

2002 ◽  
Vol 13 (21) ◽  
pp. 2383-2388 ◽  
Author(s):  
Magdolna Solymár ◽  
Ferenc Fülöp ◽  
Liisa T. Kanerva
Keyword(s):  
Candida Antarctica ◽  
Candida Antarctica Lipase ◽  
Amino Esters ◽  
Lipase A

A Continuous Reactor for the (Chemo)enzymatic Dynamic Kinetic Resolution of Rac-1-Phenylethanol in Ionic Liquid/Supercritical Carbon Dioxide Biphasic Systems

2007 ◽  
Vol 5 (1) ◽  
Author(s):  
Pedro Lozano ◽  
Teresa De Diego ◽  
Said Gmouh ◽  
Michel Vaultier ◽  
Jose L Iborra
Keyword(s):  
Carbon Dioxide ◽  
Ionic Liquid ◽  
Supercritical Carbon Dioxide ◽  
Kinetic Resolution ◽  
Candida Antarctica ◽  
Candida Antarctica Lipase B ◽  
Candida Antarctica Lipase ◽  
Dynamic Kinetic Resolution ◽  
Lipase B ◽  
Biphasic Systems

Enzymatic transformations in ionic liquids (ILs)/supercritical carbon dioxide (scCO2) biphasic systems, whereby enzyme molecules are ``immobilized" in the IL phase and substrates/products are transported by the scCO2 phase, are described as a way for carrying out clean synthetic chemical processes to produce pure products. As a model system to study, the ionic liquid butyltrimethyl ammonium (bis(trifluoromethane)sulfonyl imine) ([btma][NTf2]) was assayed for Candida antarctica lipase B (CALB)-catalyzed the kinetic resolution of rac-1-phenylethanol. The suitability of this IL was established from both the activity and stability of the enzyme. A continuous dynamic kinetic resolution (DKR) process in [btma][NTf2])/scCO2 biphasic system was carried out by using simultaneously both immobilized Candida antarctica lipase B in silica gel and silica modified with benzenosulfonic acid groups (SCX) catalysts at 50 ºC and 10 MPa, providing a good yield (78 %) for (R)-1-phenylethyl propionate product with excellent enantioselectivity (ee = 92 %) in continuous operation.

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