Preparation of Sugar β-Amino Acid Derivatives with Cyclic Structures by Ring-Closing Metathesis

2010 ◽  
Vol 2010 (31) ◽  
pp. 6092-6096 ◽  
Author(s):  
Basker Sundararaju ◽  
Tailor Sridhar ◽  
Mathieu Achard ◽  
Gangavaram V. M. Sharma ◽  
Christian Bruneau
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Ring Closing Metathesis

scholarly journals Diastereoselective Synthesis of Fluorinated, Seven-Membered β-Amino Acid Derivatives via Ring-Closing Metathesis.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Santos Fustero ◽  
Ana Bartolome ◽  
Juan F. Sanz-Cervera ◽  
Maria Sanchez-Rosello ◽  
Juan Garcia Soler ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

Synthesis of Cyclic Amino Acid Derivatives via Ring Closing Metathesis on a Poly(ethylene glycol) Supported Substrate

2000 ◽  
Vol 65 (20) ◽  
pp. 6787-6790 ◽  
Author(s):  
Stéphane Varray ◽  
Christine Gauzy ◽  
Frédéric Lamaty ◽  
René Lazaro ◽  
Jean Martinez
Keyword(s):  
Amino Acid ◽  
Ethylene Glycol ◽  
Amino Acid Derivatives ◽  
Poly Ethylene Glycol ◽  
Ring Closing Metathesis ◽  
Poly Ethylene

ChemInform Abstract: Access to Cyclic α-CF3-Substituted α-Amino Acid Derivatives by Ring-Closing Metathesis of Functionalized 1,7-Enynes.

ChemInform ◽  
2014 ◽  
Vol 45 (3) ◽  
pp. no-no
Author(s):  
Artur K. Mailyan ◽  
Ivan M. Krylov ◽  
Christian Bruneau ◽  
Pierre H. Dixneuf ◽  
Sergey N. Osipov
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Ring Closing Metathesis

Access to Cyclic α-CF3-Substituted α-Amino Acid Derivatives by Ring-Closing Metathesis of Functionalized 1,7-Enynes

2013 ◽  
Vol 2013 (24) ◽  
pp. 5353-5363 ◽  
Author(s):  
Artur K. Mailyan ◽  
Ivan M. Krylov ◽  
Christian Bruneau ◽  
Pierre H. Dixneuf ◽  
Sergey N. Osipov
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Ring Closing Metathesis

Diastereoselective Synthesis of Fluorinated, Seven-Membered β-Amino Acid Derivatives via Ring-Closing Metathesis

2003 ◽  
Vol 5 (14) ◽  
pp. 2523-2526 ◽  
Author(s):  
Santos Fustero ◽  
Ana Bartolomé, ◽  
Juan F. Sanz-Cervera ◽  
María Sánchez-Roselló ◽  
Juan García Soler ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

scholarly journals Application of Metathesis Reactions in the Synthesis and Transformations of Functionalized β-Amino Acid Derivatives

Synthesis ◽  
2018 ◽  
Vol 50 (18) ◽  
pp. 3571-3588 ◽  
Author(s):  
Loránd Kiss ◽  
Márton Kardos ◽  
Csaba Vass ◽  
Ferenc Fülöp
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Ring Opening ◽  
Amino Acid Derivatives ◽  
Ring Closing Metathesis ◽  
Ring Systems ◽  
Bond Functionalization ◽  
Cross Metathesis ◽  
Stereocontrolled Synthesis ◽  
Metathesis Reactions

Because of their biological relevance, cyclic β-amino acids have generated increasing interest and had significant impact in drug research over the past two decades. Their preparation and further functionalization towards new types of molecular entities have received large interest in synthetic and medicinal chemistry. Various types of metathesis reactions, such as ring-opening (ROM), ring-closing (RCM), or cross metathesis (CM) are used widely for access to either alicyclic β-amino acids or other densely functionalized derivatives of this group of compounds. This account intends to provide an insight into the most relevant synthetic routes to this class of derivatives with the application of metathesis reactions. The review focuses on the presentation of selective and stereocontrolled methodologies in view of versatility, robustness, limitations and efficiency.1 Introduction2 Synthesis and Transformation of Cyclic β-Amino Acids through Metathesis Reactions2.1 Synthesis of Five- and Six-Membered Cyclic β-Amino Acids by Ring-Closing Metathesis2.2 Synthesis of Five- and Six-Membered Cyclic β-Amino Acids by Cross Metathesis2.3 Synthesis of β-Amino Acids with Larger Ring Systems by Ring- Closing Metathesis2.4 Synthesis of β-Amino Acids with Condensed Ring Systems by Ring-Rearrangement Metathesis2.5 Stereocontrolled One-Step Synthesis of Functionalized Cispentacin and Transpentacin Derivatives2.5.1 Stereocontrolled Synthesis of Functionalized Cispentacin and Transpentacin Derivatives through Ring-Opening Metathesis of Norbornene β-Amino Acid Derivatives2.5.2 Stereocontrolled Synthesis of Functionalized Azetidinones and β-Amino Acid Derivatives from Condensed Ring β-Lactams by Ring-Opening Metathesis2.5.3 Carbon–Carbon Double Bond Functionalization of β-Amino Acid Derivatives and β-Lactams with α,β-Unsaturated Carbonyl Compounds through Cross Metathesis2.5.4 Synthesis of Functionalized β-Amino Acid Derivatives and β-Lactams through Chemoselective Cross Metathesis3 Conclusions and Outlook

Sign in / Sign up

Export Citation Format

Share Document