An Efficient Synthesis of 7-(Arylmethyl)-3-tert-butyl-1-phenyl-6,7-dihydro-1H,4H-pyrazolo[3,4-d][1,3]oxazines

2010 ◽  
Vol 2010 (33) ◽  
pp. 6454-6463 ◽  
Author(s):  
Rodrigo Abonia ◽  
Juan Castillo ◽  
Braulio Insuasty ◽  
Jairo Quiroga ◽  
Manuel Nogueras ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Tert Butyl

An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite

2016 ◽  
Vol 18 (8) ◽  
pp. 2323-2330 ◽  
Author(s):  
Priyanka Chaudhary ◽  
Surabhi Gupta ◽  
Nalluchamy Muniyappan ◽  
Shahulhameed Sabiah ◽  
Jeyakumar Kandasamy
Keyword(s):  
Secondary Amines ◽  
Efficient Synthesis ◽  
Efficient Manner ◽  
Tert Butyl ◽  
Solvent Metal

N-Nitrosation of secondary amines was accomplished in an efficient manner using tert-butyl nitrite under solvent, metal and acid free conditions.

A One-Pot and Efficient Synthesis of Zoledronic Acid Starting from Tert-butyl Imidazol-1-yl Acetate

2015 ◽  
Vol 48 (12) ◽  
pp. 835-839 ◽  
Author(s):  
Samer S. Ratrout ◽  
Ala’eddine M. Al Sarabi ◽  
Kamal A. Sweidan
Keyword(s):  
Zoledronic Acid ◽  
Efficient Synthesis ◽  
One Pot ◽  
Tert Butyl

Enantioselective Nitrile Anion Cyclization to Substituted Pyrrolidines. A Highly Efficient Synthesis of (3S,4R)-N-tert-Butyl-4-arylpyrrolidine-3-carboxylic Acid

ChemInform ◽  
2005 ◽  
Vol 36 (39) ◽  
Author(s):  
John Y. L. Chung ◽  
Raymond Cvetovich ◽  
Joseph Amato ◽  
J. Christopher McWilliams ◽  
Robert Reamer ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Efficient Synthesis ◽  
Tert Butyl ◽  
Highly Efficient

Synthesis and use of benzyl tert-butyl iminodicarbonate, a versatile reagent for the preparation of amines

1988 ◽  
Vol 53 (11) ◽  
pp. 2778-2786 ◽  
Author(s):  
Leif Grehn ◽  
Ulf Ragnarsson
Keyword(s):  
Benzyl Alcohol ◽  
Sodium Salt ◽  
Title Compound ◽  
Protecting Groups ◽  
Efficient Synthesis ◽  
Tert Butyl ◽  
Mild Conditions ◽  
High Yields ◽  
Versatile Reagent

An efficient synthesis of benzyl tert-butyl iminodicarbonate (IV), starting from benzoyl isocyanate, is reported. Reaction of the isocyanate with benzyl alcohol gave benzyl N-benzoylcarbamate (II) which on exhaustive tert-butoxycarbonylation via the non-isolated triacyl amine III, after aminolysis, provided the title compound. The sodium salt V was alkylated with various halides under Gabriel conditions to give in high yields the corresponding benzyloxycarbonyl tert-butoxycarbonyl diprotected amines. Similarly, compound IV was alkylated with alcohols under Mitsunobu conditions to give some additional amines of this type, from which the protecting groups can be removed selectively under mild conditions.

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