Sugar-Derived Ras Inhibitors: Group Epitope Mapping by NMR Spectroscopy and Biological Evaluation

2006 ◽  
Vol 2006 (16) ◽  
pp. 3707-3720 ◽  
Author(s):  
Francesco Peri ◽  
Cristina Airoldi ◽  
Sonia Colombo ◽  
Silvia Mari ◽  
Jesús Jiménez-Barbero ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Epitope Mapping ◽  
Biological Evaluation ◽  
Ras Inhibitors

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL BENZODIAZEPINE CONTAINING BENZOTHIAZEPINE/BENZOXAZEPINE DERIVATIVES AS POTENT ANTICONVULSANT AGENTS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (06) ◽  
pp. 7-13
Author(s):  
Archana ◽  
Keyword(s):  
Nmr Spectroscopy ◽  
Acute Toxicity ◽  
Elemental Analysis ◽  
Anticonvulsant Activity ◽  
1H Nmr Spectroscopy ◽  
Biological Evaluation ◽  
Standard Drug ◽  
Phenytoin Sodium ◽  
Synthesis And Biological Evaluation

A new series of 4-benzodiazepinyl-2-( substituted phenyl)-1,5-benzothiazepines (3a-3f) and 4-benzodiazepinyl-2-(substituted phenyl)-1,5-benzoxazepines (4a-4f) were synthesised and evaluated for their anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Compound 4-benzodiazepinyl-2-(p-methoxy phenyl)-1,5-benzothiazepine 4b, was found to be most potent compoundof this series, more potent than standard drug phenytoin sodium. The homogeneity of all the compounds was checked by TLC. The structures of these compounds have been established by elemental analysis, IR and 1H NMR spectroscopy.

Epitope mapping by solution NMR spectroscopy

2015 ◽  
Vol 28 (6) ◽  
pp. 393-400 ◽  
Author(s):  
M. Bardelli ◽  
E. Livoti ◽  
L. Simonelli ◽  
M. Pedotti ◽  
A. Moraes ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Epitope Mapping ◽  
Solution Nmr ◽  
Solution Nmr Spectroscopy

scholarly journals Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives

2014 ◽  
Vol 34 ◽  
pp. 48-54
Author(s):  
Hitesh Makwana ◽  
Yogesh T. Naliapara
Keyword(s):  
Antimicrobial Activity ◽  
Nmr Spectroscopy ◽  
Benzoic Acid ◽  
Phosphorus Oxychloride ◽  
13C Nmr Spectroscopy ◽  
Biological Evaluation ◽  
Plate Method ◽  
Benzoic Acid Derivatives ◽  
Oxadiazole Derivatives ◽  
Anti Fungal

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

scholarly journals Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein-Ligand Contacts

2017 ◽  
Vol 56 (48) ◽  
pp. 15289-15293 ◽  
Author(s):  
Serena Monaco ◽  
Louise E. Tailford ◽  
Nathalie Juge ◽  
Jesus Angulo
Keyword(s):  
Nmr Spectroscopy ◽  
Epitope Mapping ◽  
Std Nmr

Epitope Mapping of the Phosphorylation Motif of the HIV-1 Protein Vpu Bound to the Selective Monoclonal Antibody Using TRNOESY and STD NMR Spectroscopy†

Biochemistry ◽  
2004 ◽  
Vol 43 (46) ◽  
pp. 14555-14565 ◽  
Author(s):  
Josyane Gharbi-Benarous ◽  
Gildas Bertho ◽  
Nathalie Evrard-Todeschi ◽  
Gaël Coadou ◽  
Simon Megy ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Nmr Spectroscopy ◽  
Epitope Mapping ◽  
Phosphorylation Motif ◽  
Std Nmr ◽  
Hiv 1

scholarly journals Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein-Ligand Contacts

2017 ◽  
Vol 129 (48) ◽  
pp. 15491-15495 ◽  
Author(s):  
Serena Monaco ◽  
Louise E. Tailford ◽  
Nathalie Juge ◽  
Jesus Angulo
Keyword(s):  
Nmr Spectroscopy ◽  
Epitope Mapping ◽  
Std Nmr
Sign in / Sign up

Export Citation Format

Share Document