Synthesis of conjugated linoleic acid by microwave-assisted alkali isomerization using propylene glycol as solvent

2016 ◽  
Vol 119 (4) ◽  
pp. 1600079 ◽  
Author(s):  
Ana Sonia Silva-Ramírez ◽  
Alejandro Rocha-Uribe ◽  
Marco Martín González-Chávez ◽  
Carmen González
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Propylene Glycol ◽  
Alkali Isomerization ◽  
Microwave Assisted

Kinetics of Alkali Isomerization of Linoleic Acid from Walnut Oil Converted into Conjugation of Linoleic Acid

2013 ◽  
Vol 773 ◽  
pp. 316-321
Author(s):  
Xiang Feng Xiong ◽  
Chao Yin Chen ◽  
Sheng Lan Zhao ◽  
Ben Yong Han
Keyword(s):  
Linoleic Acid ◽  
Propylene Glycol ◽  
Raw Materials ◽  
Isomerization Reaction ◽  
Alkali Isomerization ◽  
Reaction Conditions ◽  
Kinetics Parameters ◽  
Walnut Oil ◽  
Mechanism Model ◽  
Kinetics Of

Conjugated linoleic acid (CLA) was prepared by alkali isomerization using walnut oil as raw materials, KOH as catalyst and propylene glycol as solvent. The kinetics of alkali isomerization of linoleic acid from walnut oil converted into CLA was experimentally studied under the reaction conditions of 393~453 K,and which the initial mass ratio of propylene glycol, walnut oil and KOH was 3:2:1. The mechanism of alkali isomerization was proposed, and the mechanism model was put forward through theoretical derivation.The rate constants were determined, the mechanism model was verified,and the kinetics parameters were obtained.The results showed that alkali isomerization reaction was first order the concentration of linoleic acid, which the apparent activation energy was 67.22 kJ·mol-1 and the pre-exponential constant was 8.963×105min-1.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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