Cationic derivative of polyprenol, a potential component of liposomal drug carriers, does not alter renal function in rats

2014 ◽  
Vol 116 (5) ◽  
pp. 659-662 ◽  
Author(s):  
Olga Gawrys ◽  
Krzysztof Hubert Olszyński ◽  
Katarzyna Gawarecka ◽  
Ewa Swiezewska ◽  
Tadeusz Chojnacki ◽  
...  
Keyword(s):  
Renal Function ◽  
Drug Carriers ◽  
Liposomal Drug ◽  
Potential Component

Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration

2021 ◽  
Author(s):  
E. Natsaridis ◽  
P. Mouzoura ◽  
F. Gkartziou ◽  
A. Marazioti ◽  
S.G. Antimisiaris
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Tissue Regeneration ◽  
Structural Characteristics ◽  
Drug Carriers ◽  
Growth Factor Delivery ◽  
Liposomal Form ◽  
Liposomal Drug ◽  
Hydrophilic Nature ◽  
Rapid Clearance

This review is an update about the efforts to develop liposomal carriers for growth factor delivery. It is well known that growth factors have the potential to enhance/accelerate tissue regeneration, however their poor stability which results in rapid loss of their activity, together with their rapid clearance from defected tissues (when applied as free molecules) is a serious drawback for their use; their highly hydrophilic nature and low capability to permeate through biological barriers (cell membranes) are additional factors that limit their applicability. In the last years, the advantages of liposomal drug delivery systems have motivated efforts to deliver growth factors (GFs) in liposomal form. Herein, after briefly introducing the basic structural characteristics of liposome types and their advantages when used as drug carriers, as well as the basic problems encountered when GFs are applied for tissue regeneration, we focus on recent reports about development and potential regenerative effects of liposomal GFs, towards defects of various tissues. The methodologies used for incorporation, attachment or immobilization of liposomal GFs in order to sustain their retention at the defected tissues, are highlighted as well.

scholarly journals Passive targeting with liposomal drug carriers.

1999 ◽  
Vol 14 (6) ◽  
pp. 433-447 ◽  
Author(s):  
Kazuo Maruyama
Keyword(s):  
Drug Carriers ◽  
Liposomal Drug ◽  
Passive Targeting

A Set of Novel Lipopeptides for Targeting of Liposomal Drug Carriers

2005 ◽  
Vol 2005 (Fall) ◽  
Author(s):  
Eik Leupold ◽  
Ines Sauer ◽  
Heike Nikolenko ◽  
Michael Bienert ◽  
Margitta Dathe
Keyword(s):  
Drug Carriers ◽  
Liposomal Drug

scholarly journals Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers

2006 ◽  
Vol 1758 (4) ◽  
pp. 552-561 ◽  
Author(s):  
Ines Sauer ◽  
Heike Nikolenko ◽  
Sandro Keller ◽  
Khalid Abu Ajaj ◽  
Michael Bienert ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Cellular Uptake ◽  
Drug Carriers ◽  
Liposomal Drug

Liposomal drug carriers

2014 ◽  
pp. 88-104
Author(s):  
Daniel S Lewi ◽  
Karina A Peters ◽  
Pedro M Politi
Keyword(s):  
Drug Carriers ◽  
Liposomal Drug

Liposomal Drug Carriers

2019 ◽  
pp. 349-376
Author(s):  
Juliana Palma Abriata ◽  
Marcela Tavares Luiz ◽  
Giovanni Loureiro Raspantini ◽  
Patrícia Mazureki Campos ◽  
Juliana Maldonado Marchetti
Keyword(s):  
Drug Carriers ◽  
Liposomal Drug

Impact of Liposomal Drug Carriers on Drug Pharmacokinetics

1985 ◽  
Vol 74 (8) ◽  
pp. 897-898 ◽  
Author(s):  
C. Anthony Hunt ◽  
Roderick D. Macgregor
Keyword(s):  
Drug Carriers ◽  
Liposomal Drug ◽  
Drug Pharmacokinetics

scholarly journals Development of liposomal drug formulations: quality attributes and methods for quality control

2018 ◽  
pp. 33-39
Author(s):  
E.V. Melnikova ◽  
D.V. Goryachev ◽  
A.A. Chaplenko ◽  
M.A. Vodyakova ◽  
A.R. Sayfutdinova ◽  
...  
Keyword(s):  
Quality Control ◽  
Gel Filtration ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Quality Attributes ◽  
Scanning Calorimetry ◽  
Liposomal Drug ◽  
Wide Range ◽  
Drug Manufacturing ◽  
Major Trend

The use of nanostructured components in drug manufacturing and, more specifically, targeted drug delivery has recently become a major trend in the pharmaceutical industry. Nanodrugs encompass a wide range of pharmaceutical agents containing dendrimers, nanocrystals, micelles, liposomes, and polymer nanoparticles. Liposomes are the most well-studied nanoparticles and effective drug carriers. However, the more complex their structure is, the more process controls are needed and the more quality attributes have to be monitored, including the chemical properties of the liposomal fraction such as the shape, size and charge of the nanoparticle, conjugation efficacy, and distribution of the active ingredient. We believe that quality control of key liposome characteristics should rely on dynamic and laser light scattering coupled with electrophoresis, differential scanning calorimetry, cryo-electron microscopy, nuclear magnetic resonance, laser diffraction analysis, and gel filtration chromatography.

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