Evaluation of a model system for the selective study of the lipid peroxidation process

2012 ◽  
Vol 114 (11) ◽  
pp. 1292-1303
Author(s):  
Branka Mihaljević ◽  
Ivana Tartaro ◽  
Nada Filipović Vinceković
Keyword(s):  
Lipid Peroxidation ◽  
Model System ◽  
Lipid Peroxidation Process

Catalase prevents prostanoid release and lung lipid peroxidation after endotoxemia in sheep

1988 ◽  
Vol 65 (3) ◽  
pp. 1210-1216 ◽  
Author(s):  
A. Seekamp ◽  
C. Lalonde ◽  
D. G. Zhu ◽  
R. Demling
Keyword(s):  
Lipid Peroxidation ◽  
Water Content ◽  
Fold Increase ◽  
Conjugated Dienes ◽  
Base Line ◽  
Lipid Peroxidation Process ◽  
Adult Sheep ◽  
Lung Lipid ◽  
Arterial Plasma ◽  
Lung Lymph

We determined the effect of H2O2 on both the physiological and biochemical lung changes seen in the adult sheep after endotoxin. Fourteen unanesthetized adult sheep with chronic lung lymph fistula were given Escherichia coli endotoxin (1 microgram/kg) over 30 min. Seven sheep were given catalase (32,500 U/kg body wt) as an intravenous bolus 30 min before endotoxin. Four sheep were given catalase alone. Oxidant lung changes were measured using arterial plasma conjugated dienes and lung tissue malondialdehyde (MDA) content, both reflecting the lipid peroxidation process. Animals were killed 5 h after endotoxin. We found that endotoxin alone caused an early increase in pulmonary arterial pressure lung lymph flow (QL), plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, and plasma conjugated dienes. A decrease in cardiac output and arterial PO2 was also seen. A three- to four-fold increase in protein-rich QL was noted at 3-4 h as well as a continued increase in arterial conjugated dienes. Lung MDA and water content were also significantly increased from base line. Catalase pretreatment significantly attenuated both the physiological changes and the prostanoid and conjugated diene release. Lung MDA and water content also remained at base line. We conclude that H2O2 plays a major role in endotoxin-induced lung injury as well as the resulting lipid peroxidation process.

Spectroscopic detection of lipid peroxidation products and structural changes in a sphingomyelin model system

1991 ◽  
Vol 1081 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Om P. Lamba ◽  
Sundeep Lal ◽  
M. Cecilia Yappert ◽  
Marjorie F. Lou ◽  
Douglas Borchman
Keyword(s):  
Lipid Peroxidation ◽  
Structural Changes ◽  
Model System ◽  
Lipid Peroxidation Products

scholarly journals Original article Suppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis

2013 ◽  
Vol 1 ◽  
pp. 51-57 ◽  
Author(s):  
Srdjan Ljubisavljevic ◽  
Ivana Stojanovic ◽  
Dusica Pavlovic ◽  
Maja Milojkovic ◽  
Dusan Sokolovic ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Autoimmune Encephalomyelitis ◽  
Lipid Peroxidation Process ◽  
Experimentally Induced

Cellular model to assay the lipid peroxidation process and its inhibition

2012 ◽  
Vol 211 ◽  
pp. S167
Author(s):  
Miriana Gubandru ◽  
Denisa Margina ◽  
Mihaela Ilie ◽  
Dan Balalau
Keyword(s):  
Lipid Peroxidation ◽  
Cellular Model ◽  
Lipid Peroxidation Process
Sign in / Sign up

Export Citation Format

Share Document