Effects of Orlistat on white adipose tissue (WAT) in the γ-irradiated mouse model

2010 ◽  
Vol 112 (12) ◽  
pp. 1384-1388 ◽  
Author(s):  
Changhyun Roh ◽  
Nam-Hee Choi ◽  
Hae-Ran Park ◽  
Uhee Jung ◽  
Sung Kee Jo
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
White Adipose Tissue

scholarly journals Transcriptome profiling of white adipose tissue in a mouse model for 15q duplication syndrome

Genomics Data ◽  
2015 ◽  
Vol 5 ◽  
pp. 394-396 ◽  
Author(s):  
Xiaoxi Liu ◽  
Kota Tamada ◽  
Rui Kishimoto ◽  
Hiroko Okubo ◽  
Satoko Ise ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
White Adipose Tissue ◽  
Transcriptome Profiling ◽  
15Q Duplication ◽  
Duplication Syndrome

scholarly journals White Adipose Tissue Browning in the R6/2 Mouse Model of Huntington’s Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0159870 ◽  
Author(s):  
Andrew C. McCourt ◽  
Lovisa Jakobsson ◽  
Sara Larsson ◽  
Cecilia Holm ◽  
Sarah Piel ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
White Adipose Tissue ◽  
Tissue Browning

scholarly journals ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Lakshini Weerasekera ◽  
Caroline Rudnicka ◽  
Qing-Xiang Sang ◽  
Joanne E. Curran ◽  
Matthew P. Johnson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Mouse Model ◽  
White Adipose Tissue ◽  
Mononuclear Cells ◽  
Western World ◽  
Diet Induced Obesity ◽  
The Metabolic Syndrome

Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model. Finally, we investigated the effect of neutralising ADAM19 on diet induced weight gain, insulin resistance in vivo, and liver TNF-α levels. Significantly, we show that, in humans, ADAM19 strongly correlates with parameters of the metabolic syndrome, particularly BMI, relative fat, HOMA-IR, and triglycerides. Furthermore, we identified that ADAM19 expression was markedly increased in the liver and gonadal white adipose tissue of obese and T2D mice. Excitingly, we demonstrate in our diet induced obesity mouse model that neutralising ADAM19 therapy results in weight loss, improves insulin sensitivity, and reduces liver TNF-α levels. Our novel data suggest that ADAM19 is pro-obesogenic and enhances insulin resistance. Therefore, neutralisation of ADAM19 may be a potential therapeutic approach to treat obesity and T2D.

scholarly journals Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Gregory A. Raciti ◽  
Rosa Spinelli ◽  
Antonella Desiderio ◽  
Michele Longo ◽  
Luca Parrillo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
White Adipose Tissue ◽  
Down Regulation ◽  
Diet Induced Obesity

Inflammatory Response in White Adipose Tissue in the Non-Obese Hormone-Sensitive Lipase Null Mouse Model

2006 ◽  
Vol 5 (7) ◽  
pp. 1701-1710 ◽  
Author(s):  
Ola Hansson ◽  
Kristoffer Ström ◽  
Nuray Güner ◽  
Nils Wierup ◽  
Frank Sundler ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Response ◽  
Mouse Model ◽  
White Adipose Tissue ◽  
Hormone Sensitive Lipase ◽  
Null Mouse ◽  
Hormone Sensitive

scholarly journals The Antiobesity Effects of Buginawa in 3T3-L1 Preadipocytes and in a Mouse Model of High-Fat Diet-Induced Obesity

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Yea-Jin Park ◽  
Dong-Wook Seo ◽  
Jae-Yun Ju ◽  
Yun-Yeop Cha ◽  
Hyo-Jin An
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Liver Tissue ◽  
Binding Protein ◽  
Medicinal Herbs ◽  
High Fat ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biological activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs with potential for weight loss induction. We hypothesized that Bugi may have antiobesity effects in 3T3-L1 preadipocytes and in a high-fat diet- (HFD-) induced mouse model. In this study, 3T3-L1 cells were treated with varied concentrations of Bugi (62.5, 125, or 250 μg/mL). Bugi treatment inhibited adipocyte differentiation by suppressing adipogenic transcription genes, including peroxisome proliferator-activated receptor γ protein (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory element-binding protein 1 (SREBP1), and CCAAT/enhancer-binding protein β (C/EBPβ). Mice were fed a normal diet or an HFD for 11 weeks, and Bugi was simultaneously administered at 50 or 100 mg/kg. Bugi administration significantly reduced body weight gain and white adipose tissue (WAT) weight and effectively inhibited lipid droplet accumulation in epididymal white adipose tissue (eWAT) and liver tissue. Further, Bugi treatment suppressed mRNA levels of PPARγ, C/EBPα, and SREBP1 in eWAT and liver tissue. Our findings demonstrate that Bugi could be an effective candidate for preventing obesity and related metabolic disorders.

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