scholarly journals Ruthenium Arene Complexes with α-Aminoacidato Ligands: New Insights into Transfer Hydrogenation Reactions and Cytotoxic Behaviour

2018 ◽  
Vol 2018 (26) ◽  
pp. 3041-3057 ◽  
Author(s):  
Lorenzo Biancalana ◽  
Issam Abdalghani ◽  
Federica Chiellini ◽  
Stefano Zacchini ◽  
Guido Pampaloni ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Arene Complexes ◽  
Hydrogenation Reactions ◽  
Ruthenium Arene

scholarly journals Transfer Hydrogenation Reactions of Photoactivatable N,N’-Chelated Ruthenium(II) Arene Complexes

2017 ◽  
Vol 57 (3) ◽  
Author(s):  
Soledad Betanzos-Lara ◽  
Abraha Habtemariam ◽  
Peter J. Sadler
Keyword(s):  
Aqueous Solution ◽  
Catalytic Activity ◽  
Sodium Formate ◽  
Transfer Hydrogenation ◽  
Arene Complexes ◽  
Chelating Ligand ◽  
Spontaneous Hydrolysis ◽  
Hydrogenation Reactions ◽  
Excess Sodium ◽  
Hydrolysis Of

We show that the reaction of Ru<sup>II</sup> arene chlorido complexes of the type [(η<sup>6</sup>-arene)Ru(N,N’)Cl]<sup>+</sup> arene = p-cymene (pcym), hexamethylbenzene (hmb), indane (ind), <em>N,N’</em> = bipyrimidine (bpm) and 1,10-phenanthroline (phen) with excess sodium formate generates a very stable formate adduct through spontaneous hydrolysis of the Ru-Cl bond at 310 K and pH* = 7.0. The formate adducts are also produced when Ru<sup>II</sup> arene pyridine complexes of the type [(η<sup>6</sup>-arene)Ru(N,N’)(Py)]<sup>2+</sup> (where Py = pyridine), are irradiated with UVA (λ<sub>irr</sub> = 300-400 nm) or visible light (λ<sub>irr</sub> = 400-660 nm) under the same conditions. The Ru<sup>II</sup> arene formato adducts do not catalyse the reduction of acetone through transfer hydrogenation. However, all the complexes (except complex <strong>2</strong> which contains phen as the chelating ligand) can catalyse the regioselective reduction of NAD<sup>+</sup> in the presence of formate (25 mol equiv) in aqueous solution to form 1,4-NADH. The catalytic activity is dependent on the nature of the chelating ligand. Most interestingly, the regioselective reduction of NAD+ to 1,4-NADH can be also specifically triggered by photoactivating a RuII arene Py complex.

Catch It If You Can: Copper-Catalyzed (Transfer) Hydrogenation Reactions and Coupling Reactions by Intercepting Reactive Intermediates Thereof

Synthesis ◽  
2020 ◽  
Vol 52 (17) ◽  
pp. 2483-2496
Author(s):  
Johannes F. Teichert ◽  
Lea T. Brechmann
Keyword(s):  
Coupling Reaction ◽  
Reactive Intermediates ◽  
Transfer Hydrogenation ◽  
Coupling Reactions ◽  
Bond Forming ◽  
Starting Point ◽  
Bond Forming Reactions ◽  
Hydrogenation Reactions ◽  
Multicomponent Coupling Reactions ◽  
Trapping Reactions

The key reactive intermediate of copper(I)-catalyzed alkyne semihydrogenations is a vinylcopper(I) complex. This intermediate can be exploited as a starting point for a variety of trapping reactions. In this manner, an alkyne semihydrogenation can be turned into a dihydrogen­-mediated coupling reaction. Therefore, the development of copper-catalyzed (transfer) hydrogenation reactions is closely intertwined with the corresponding reductive trapping reactions. This short review highlights and conceptualizes the results in this area so far, with H2-mediated carbon–carbon and carbon–heteroatom bond-forming reactions emerging under both a transfer hydrogenation setting as well as with the direct use of H2. In all cases, highly selective catalysts are required that give rise to atom-economic multicomponent coupling reactions with rapidly rising molecular complexity. The coupling reactions are put into perspective by presenting the corresponding (transfer) hydrogenation processes first.1 Introduction: H2-Mediated C–C Bond-Forming Reactions2 Accessing Copper(I) Hydride Complexes as Key Reagents for Coupling Reactions; Requirements for Successful Trapping Reactions 3 Homogeneous Copper-Catalyzed Transfer Hydrogenations4 Trapping of Reactive Intermediates of Alkyne Transfer Semi­hydrogenation Reactions: First Steps Towards Hydrogenative Alkyne Functionalizations 5 Copper(I)-Catalyzed Alkyne Semihydrogenations6 Copper(I)-Catalyzed H2-Mediated Alkyne Functionalizations; Trapping of Reactive Intermediates from Catalytic Hydrogenations6.1 A Detour: Copper(I)-Catalyzed Allylic Reductions, Catalytic Generation of Hydride Nucleophiles from H2 6.2 Trapping with Allylic Electrophiles: A Copper(I)-Catalyzed Hydro­allylation Reaction of Alkynes 6.3 Trapping with Aryl Iodides7 Conclusion

ChemInform Abstract: NiO-Al2O3 Prepared from a Ni-Al Hydrotalcite Precursor as an Efficient Catalyst for Transfer Hydrogenation Reactions.

ChemInform ◽  
2010 ◽  
Vol 31 (33) ◽  
pp. no-no
Author(s):  
T. M. Jyothi ◽  
T. Raja ◽  
M. B. Talawar ◽  
K. Sreekumar ◽  
S. Sugunan ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Efficient Catalyst ◽  
Hydrogenation Reactions

scholarly journals Enantiomerically Enriched 1,2-P,N-Bidentate Ferrocenyl Ligands for 1,3-Dipolar Cycloaddition and Transfer Hydrogenation Reactions

Molecules ◽  
2018 ◽  
Vol 23 (6) ◽  
pp. 1311 ◽  
Author(s):  
Irina Utepova ◽  
Polina Serebrennikova ◽  
Marina Streltsova ◽  
Alexandra Musikhina ◽  
Tatiana Fedorchenko ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Dipolar Cycloaddition ◽  
Ferrocenyl Ligands ◽  
Hydrogenation Reactions

Facile assembly of bifunctional, magnetically retrievable mesoporous silica for enantioselective cascade reactions

2019 ◽  
Vol 55 (90) ◽  
pp. 13578-13581 ◽  
Author(s):  
Zhongrui Zhao ◽  
Fengwei Chang ◽  
Tao Wang ◽  
Lijian Wang ◽  
Lingbo Zhao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cross Coupling ◽  
Bifunctional Catalyst ◽  
Cascade Reactions ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Aromatic Alcohols ◽  
Hydrogenation Reactions ◽  
Successive Reduction

A magnetically recyclable bifunctional catalyst enables synergistic Suzuki cross-coupling/asymmetric transfer hydrogenation and successive reduction/asymmetric transfer hydrogenation reactions for the preparation of chiral aromatic alcohols.

Microwave-Assisted Ruthenium-Catalyzed Reactions

2009 ◽  
Vol 62 (3) ◽  
pp. 184 ◽  
Author(s):  
François Nicks ◽  
Yannick Borguet ◽  
Sébastien Delfosse ◽  
Dario Bicchielli ◽  
Lionel Delaude ◽  
...  
Keyword(s):  
Reaction Times ◽  
Transfer Hydrogenation ◽  
Conventional Heating ◽  
Organic Chemical ◽  
Side Reactions ◽  
Chemical Transformations ◽  
Exchange Reactions ◽  
Present Contribution ◽  
Hydrogenation Reactions ◽  
Catalyzed Reactions

Since the first reports on the use of microwave irradiation to accelerate organic chemical transformations, a plethora of papers has been published in this field. In most examples, microwave heating has been shown to dramatically reduce reaction times, increase product yields, and enhance product purity by reducing unwanted side reactions compared with conventional heating methods. The present contribution aims at illustrating the advantages of this technology in homogeneous catalysis by ruthenium complexes and, when data are available, at comparing microwave-heated and conventionally heated experiments. Selected examples refer to olefin metathesis, isomerization reactions, 1,3-dipolar cycloadditions, atom transfer radical reactions, transfer hydrogenation reactions, and H/D exchange reactions.

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