Equilibrium Studies on Complex-Formation Reactions of Pd[(2-(2-aminoethyl)pyridine)(H2O)2]2+with Ligands of Biological Significance and Displacement Reactions of DNA Constituents

2009 ◽  
Vol 2009 (26) ◽  
pp. 3912-3920 ◽  
Author(s):  
Mohamed R. Shehata ◽  
Mohamed M. Shoukry ◽  
Fatma H. Abdel-Shakour ◽  
Rudi van Eldik
Keyword(s):  
Complex Formation ◽  
Biological Significance ◽  
Equilibrium Studies ◽  
Dna Constituents ◽  
Displacement Reactions

scholarly journals Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity: Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+with Ligands of Biological Significance and Displacement Reactions of DNA Constituents

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Eman Mohamed Shoukry
Keyword(s):  
Concentration Distribution ◽  
Antitumour Activity ◽  
Equilibrium Constants ◽  
Biological Significance ◽  
Dicarboxylic Acids ◽  
Base Hydrolysis ◽  
Biologically Relevant ◽  
Dna Constituents ◽  
Displacement Reactions ◽  
Mechanism Of Hydrolysis

The[Pd(DEEN)Cl2]and[Pt(DEEN)Cl2]complexes were synthesized and characterized whereDEEN=N,N-diethylethylenediamine. The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and[Pd(DEEN)(H2O)2]2+were investigated at37∘Cand 0.16 M ionic strength. The stability constant of the complexes formed in solution were determined and the binding centres of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated The equilibrium constants for the displacement of representative coordinated ligands such as inosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species were evaluated. The kinetics of base hydrolysis of free and coordinated S-methylcysteine methyl ester was investigated. The mechanism of hydrolysis was discussed.

Equilibrium Studies of Alkyltin(IV) Complexes with D-Glucosamine

1997 ◽  
Vol 62 (7) ◽  
pp. 1023-1028 ◽  
Author(s):  
Mohamed M. Shoukry ◽  
Samir M. El-Medani
Keyword(s):  
Complex Formation ◽  
Stability Constants ◽  
Acid Base ◽  
Complex Formation Equilibria ◽  
Equilibrium Studies ◽  
Formation Equilibria ◽  
Effects Of Temperature ◽  
The Stability

The acid-base and complex-formation equilibria involving glucosamine and its complexes with alkyltin(IV) chlorides have been studied by potentiometric technique. The results prove to a formation of 1 : 1 complex with trialkyltin(IV) and both 1 : 1 and 1 : 2 complexes with dialkyltin(IV) species. The stability constants in water were determined, the effects of temperature (from 15 to 35 °C) and ethanol (up to 88 vol.%) was studied and the speciation of the complexes was resolved.

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