Phosphate Ester Hydrolysis: Metal Complexes As Purple Acid Phosphatase and Phosphotriesterase Analogues

2009 ◽  
Vol 2009 (19) ◽  
pp. 2745-2758 ◽  
Author(s):  
Lawrence R. Gahan ◽  
Sarah J. Smith ◽  
Ademir Neves ◽  
Gerhard Schenk
Keyword(s):  
Acid Phosphatase ◽  
Metal Complexes ◽  
Ester Hydrolysis ◽  
Purple Acid Phosphatase ◽  
Phosphate Ester ◽  
Phosphate Ester Hydrolysis

A Potentially Polymerizable Heterodinuclear FeIIIZnII Purple Acid Phosphatase Mimic. Synthesis, Characterization, and Phosphate Ester Hydrolysis Studies

2011 ◽  
Vol 64 (3) ◽  
pp. 258 ◽  
Author(s):  
Yoke Leng Michelle Zee ◽  
Lawrence R. Gahan ◽  
Gerhard Schenk
Keyword(s):  
Mass Spectrometry ◽  
Catalytic Activity ◽  
Acid Phosphatase ◽  
Residual Activity ◽  
Purple Acid Phosphatase ◽  
Phosphate Ester ◽  
Ir Spectrometry ◽  
Pka Values ◽  
Phosphate Ester Hydrolysis ◽  
Rate Profile

An analogue of the purple acid phosphatase biomimetic 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((2-hydroxybenzyl)(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol has been synthesized. The analogue, 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((2-hydroxy-4-(4-vinylbenzyloxy)benzyl)(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol (H2BPBPMPV) possesses a pendant olefin suitable for copolymerization. Complexation with FeIII/ZnII resulted in the complex [FeIIIZnII(BPBPMPV)(CH3COO)2](ClO4), characterized with mass spectrometry, microanalysis, UV/vis, and IR spectrometry. The catalytic activity of the complex toward bis-(2,4-dinitrophenyl) phosphate was determined, resulting in Km of 4.1 ± 0.6 mM, with kcat 3.8 ± 0.2 × 10–3 s–1 and a bell-shaped pH–rate profile with pKa values of 4.31, 5.66, 8.96, the profile exhibiting residual activity above pH 9.5.

scholarly journals Recent Advances in Heterogeneous Catalytic Systems Containing Metal Ions for Phosphate Ester Hydrolysis

2020 ◽  
Author(s):  
Marco Antônio G. B. Gomes ◽  
Christiane Fernandes ◽  
Lawrence R. Gahan ◽  
Gerhard Schenk ◽  
Adolfo Horn
Keyword(s):  
Metal Ions ◽  
Ester Hydrolysis ◽  
Phosphate Ester ◽  
Catalytic Systems ◽  
Phosphate Ester Hydrolysis ◽  
Heterogeneous Catalytic ◽  
Recent Advances

Efficient Catalysis of Phosphate Ester Hydrolysis by Bare Silica

2020 ◽  
Vol 124 (31) ◽  
pp. 17111-17120
Author(s):  
Samara B. B. B. Bahia ◽  
Carlos A. Amaya Vargas ◽  
Ângelo M. L. Denadai ◽  
Maria Helena Araujo ◽  
Adolfo H. Moraes ◽  
...  
Keyword(s):  
Ester Hydrolysis ◽  
Phosphate Ester ◽  
Phosphate Ester Hydrolysis
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