Metal-Controlled Stereoselectivity in Complex Formation: Assembly of Tetranuclear Copper(I) Complexes with Four Stereogenic Nitrogen Donor Functions in all-(R) and all-(S) Configurations

2003 ◽  
Vol 2003 (9) ◽  
pp. 1727-1734 ◽  
Author(s):  
Jörg Schneider ◽  
Martin Köckerling ◽  
Rodion Kopitzky ◽  
Gerald Henkel
Keyword(s):  
Complex Formation ◽  
Nitrogen Donor

Thermodynamics of lanthanide(III) complex formation with nitrogen-donor ligands in dimethyl sulfoxide

1993 ◽  
pp. 1695 ◽  
Author(s):  
Alberto Cassol ◽  
Gregory R. Choppin ◽  
Plinio Di Bernardo ◽  
Roberto Portanova ◽  
Marilena Tolazzi ◽  
...  
Keyword(s):  
Complex Formation ◽  
Dimethyl Sulfoxide ◽  
Donor Ligands ◽  
Nitrogen Donor Ligands ◽  
Nitrogen Donor

Comparative Labelling and Biokinetic Studies of 99mTc-EDTA(Sn) and 99mTc-DTPA(Sn)

1977 ◽  
Vol 16 (01) ◽  
pp. 30-35 ◽  
Author(s):  
N. Agha ◽  
R. B. R. Persson
Keyword(s):  
Complex Formation ◽  
Significant Influence ◽  
Room Temperature ◽  
Ph Value ◽  
Maximum Activity ◽  
Reduction Step ◽  
Labelling Yield ◽  
Different Temperatures ◽  
Kinetics Of

SummaryGelchromatography column scanning has been used to study the fractions of 99mTc-pertechnetate, 99mTcchelate and reduced hydrolyzed 99mTc in preparations of 99mTc-EDTA(Sn) and 99mTc-DTPA(Sn). The labelling yield of 99mTc-EDTA(Sn) chelate was as high as 90—95% when 100 μmol EDTA · H4 and 0.5 (Amol SnCl2 was incubated with 10 ml 99mTceluate for 30—60 min at room temperature. The study of the influence of the pH-value on the fraction of 99mTc-EDTA shows that pH 2.8—2.9 gave the best labelling yield. In a comparative study of the labelling kinetics of 99mTc-EDTA(Sn) and 99mTc- DTPA(Sn) at different temperatures (7, 22 and 37°C), no significant influence on the reduction step was found. The rate constant for complex formation, however, increased more rapidly with increased temperature for 99mTc-DTPA(Sn). At room temperature only a few minutes was required to achieve a high labelling yield with 99mTc-DTPA(Sn) whereas about 60 min was required for 99mTc-EDTA(Sn). Comparative biokinetic studies in rabbits showed that the maximum activity in kidneys is achieved after 12 min with 99mTc-EDTA(Sn) but already after 6 min with 99mTc-DTPA(Sn). The long-term disappearance of 99mTc-DTPA(Sn) from the kidneys is about five times faster than that for 99mTc-EDTA(Sn).

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