Circulating microparticles from subjects with active pulmonary tuberculosis infection modulate immune response

2021 ◽  
Author(s):  
Josimar Dornelas Moreira ◽  
Fernanda Freire Campos Nunes ◽  
Fernanda Cristina Gontijo Evangelista ◽  
Henrique Rodrigues Silva ◽  
Marcela iranda de Tonaco ◽  
...  
Keyword(s):  
Immune Response ◽  
Pulmonary Tuberculosis ◽  
Tuberculosis Infection ◽  
Active Pulmonary Tuberculosis ◽  
Circulating Microparticles

IgA Immune Response against the Mycobacterial Antigen A60 in Patients with Active Pulmonary Tuberculosis

Respiration ◽  
1996 ◽  
Vol 63 (5) ◽  
pp. 292-297 ◽  
Author(s):  
Marco Alifano ◽  
Matteo Sofia ◽  
Mauro Mormile ◽  
Assunta Micco ◽  
Angela Filomena Mormile ◽  
...  
Keyword(s):  
Immune Response ◽  
Pulmonary Tuberculosis ◽  
Mycobacterial Antigen ◽  
Active Pulmonary Tuberculosis ◽  
Antigen A60

scholarly journals Densely calcified tuberculous constrictive pericarditis with concurrent active pulmonary tuberculosis infection

2015 ◽  
Vol 10 (2) ◽  
pp. 41-43
Author(s):  
S Laudari ◽  
S Dhungel ◽  
S Gautam ◽  
L Dubey ◽  
G Prasad ◽  
...  
Keyword(s):  
Developing Countries ◽  
Pulmonary Tuberculosis ◽  
Constrictive Pericarditis ◽  
Chronic Infection ◽  
Tuberculosis Infection ◽  
Medical Sciences ◽  
Rare Presentation ◽  
Active Pulmonary Tuberculosis ◽  
Acid Fast Bacilli

Though pulmonary tuberculosis is a common chronic infection in the developing countries like Nepal, the incidence of tubercular constrictive pericarditis is very low. Here we report a patient of active pulmonary tuberculosis with sputum positive for acid fast bacilli along with densely calcified constrictive pericarditis which has been reported as a very rare presentation in the literature.DOI: http://dx.doi.org/10.3126/jcmsn.v10i2.12955 Journal of College of Medical Sciences-Nepal, 2014, Vol.10(2); 41-43

scholarly journals Tuberculosis State Is Associated with Expression of Toll-Like Receptor 2 in Sputum Macrophages

mSphere ◽  
2017 ◽  
Vol 2 (6) ◽  
Author(s):  
Karim Lakehal ◽  
David Levine ◽  
Kathleen F. Kerr ◽  
Pooja Vir ◽  
Natalie Bruiners ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Latent Infection ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Surface Markers ◽  
Toll Like Receptor ◽  
Active Pulmonary Tuberculosis ◽  
Toll Like Receptor 2

ABSTRACT Mycobacterium tuberculosis is an intracellular pathogen that parasitizes the host macrophage. While approximately two billion people are infected worldwide, only 5 to 10% become diseased with pulmonary tuberculosis, at least in the absence of comorbidities. Tuberculosis control requires development of noninvasive methods probing the host immune status to help distinguish latent infection from active tuberculosis. With such methods, high-risk individuals could be targeted for treatment before disease manifestation. Previous investigations have been based on examination of peripheral blood cells or, more rarely, lung macrophages obtained with invasive procedures, such as bronchoalveolar lavages. Here we show that differences exist in the expression of a surface protein (Toll-like receptor 2) between macrophages recovered from the sputum of individuals in different diagnostic groups: i.e., infection free, latent tuberculosis infection, and active pulmonary tuberculosis. Thus, phenotypic analysis of local macrophages obtained with noninvasive procedures can help distinguish among tuberculosis infection stages. During tuberculosis, macrophages are critical for both pathogen survival and host immune activation. Since expression of particular cell surface markers reflects cell function, we used flow cytometry to measure the abundance of surface markers associated with polarity, lipid uptake, or pattern recognition on macrophages found in induced sputum. Nine macrophage surface markers were examined from three groups of donors: infection-free, latent tuberculosis infection, and active pulmonary tuberculosis. Using a trend test, we found that expression of Toll-like receptor 2 was greater from absence of infection to latent infection and from latent infection to active tuberculosis. The results point to the possibility that innate immune cell phenotypes be used to distinguish among tuberculosis infection stages. Moreover, this study shows that readily accessible sputum macrophages have potential for tuberculosis diagnosis and prognosis. IMPORTANCE Mycobacterium tuberculosis is an intracellular pathogen that parasitizes the host macrophage. While approximately two billion people are infected worldwide, only 5 to 10% become diseased with pulmonary tuberculosis, at least in the absence of comorbidities. Tuberculosis control requires development of noninvasive methods probing the host immune status to help distinguish latent infection from active tuberculosis. With such methods, high-risk individuals could be targeted for treatment before disease manifestation. Previous investigations have been based on examination of peripheral blood cells or, more rarely, lung macrophages obtained with invasive procedures, such as bronchoalveolar lavages. Here we show that differences exist in the expression of a surface protein (Toll-like receptor 2) between macrophages recovered from the sputum of individuals in different diagnostic groups: i.e., infection free, latent tuberculosis infection, and active pulmonary tuberculosis. Thus, phenotypic analysis of local macrophages obtained with noninvasive procedures can help distinguish among tuberculosis infection stages.

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