scholarly journals Regulatory T‐cells and transplantation tolerance : Emerging from the darkness?

2021 ◽  
Author(s):  
Herman Waldmann
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance

scholarly journals Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance

2009 ◽  
Vol 21 (4) ◽  
pp. 379-391 ◽  
Author(s):  
Kanji Nagahama ◽  
Zoltan Fehervari ◽  
Takatoku Oida ◽  
Tomoyuki Yamaguchi ◽  
Osamu Ogawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Differential Control

scholarly journals Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

Immunity ◽  
2003 ◽  
Vol 19 (4) ◽  
pp. 503-514 ◽  
Author(s):  
Xin Xiao Zheng ◽  
Alberto Sánchez-Fueyo ◽  
Masayuki Sho ◽  
Christoph Domenig ◽  
Mohamed H Sayegh ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance

scholarly journals Clinical perspectives for regulatory T cells in transplantation tolerance

2011 ◽  
Vol 23 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Keli L. Hippen ◽  
James L. Riley ◽  
Carl H. June ◽  
Bruce R. Blazar
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance

Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells

Blood ◽  
2002 ◽  
Vol 100 (9) ◽  
pp. 3408-3414 ◽  
Author(s):  
Kevin J. Young ◽  
Liming Yang ◽  
M. James Phillips ◽  
Li Zhang
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nonhuman Primates ◽  
Cell Receptor ◽  
Donor Lymphocyte Infusion ◽  
Transplantation Tolerance ◽  
Double Negative ◽  
Skin Grafts ◽  
Skin Allografts ◽  
Specific Tolerance

Abstract Donor-lymphocyte infusion (DLI) before transplantation can lead to specific tolerance to allografts in mice, nonhuman primates, and humans. We and others have demonstrated a role for regulatory T cells in DLI-induced, donor-specific transplantation tolerance, but it is not known how regulatory T cells are activated and where they execute their function. In this study, we observed, in both transgenic and normal mice, that DLI before transplantation is required for activation of αβ-T-cell-receptor–positive, CD3+CD4−CD8− double-negative (DN) regulatory T cells in the periphery of recipient mice. More interestingly, DLI induced DN regulatory T cells to migrate preferentially to donor-specific allogeneic skin grafts and to form a majority of graft-infiltrating T cells in accepted skin allografts. Furthermore, both recipient-derived peripheral and graft-infiltrating DN T cells were able to suppress and kill antidonor CD8+ T cells in an antigen-specific manner. These data indicate that DLI may induce donor-specific transplantation tolerance by activating recipient DN regulatory T cells in the periphery and by promoting migration of regulatory T cells to donor-specific allogeneic skin grafts. Our results also show that DN regulatory T cells can eliminate antidonor T cells both systemically and locally, a finding suggesting that graft-infiltrating T cells can be beneficial to graft survival.

scholarly journals Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

2011 ◽  
Vol 208 (10) ◽  
pp. 2043-2053 ◽  
Author(s):  
Adrian R. Kendal ◽  
Ye Chen ◽  
Frederico S. Regateiro ◽  
Jianbo Ma ◽  
Elizabeth Adams ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tissue Damage ◽  
Paradigm Shift ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Self Tolerance ◽  
Infectious Tolerance ◽  
First Time

A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4+Foxp3+ cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3hCD2 mice to isolate and ablate Foxp3+ T reg cells with an anti-hCD2 antibody, we show for the first time that CD4+Foxp3+ cells are crucial for infectious tolerance induced by nonablative anti–T cell antibodies. In tolerant animals, Foxp3+ T reg cells are constantly required to suppress effector T cells still capable of causing tissue damage. Tolerated tissue contains T cells that are capable of rejecting it, but are prevented from doing so by therapeutically induced Foxp3+ T reg cells. Finally, Foxp3+ cells have been confirmed as the critical missing link through which infectious tolerance operates in vivo. Peripherally induced Foxp3+ cells sustain tolerance by converting naive T cells into the next generation of Foxp3+ cells. Empowering Foxp3+ regulatory T cells in vivo offers a tractable route to avoid and correct tissue immunopathology.

Regulatory T Cells and Transplantation Tolerance

2006 ◽  
Vol 67 (10) ◽  
pp. 765-776 ◽  
Author(s):  
Shuiping Jiang ◽  
Robert I. Lechler ◽  
Xiao-Shun He ◽  
Jie-Fu Huang
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance

Regulatory T cells in transplantation tolerance

2003 ◽  
Vol 3 (3) ◽  
pp. 199-210 ◽  
Author(s):  
Kathryn J. Wood ◽  
Shimon Sakaguchi
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance

scholarly journals Harnessing FOXP3+ regulatory T cells for transplantation tolerance

2014 ◽  
Vol 124 (4) ◽  
pp. 1439-1445 ◽  
Author(s):  
Herman Waldmann ◽  
Robert Hilbrands ◽  
Duncan Howie ◽  
Stephen Cobbold
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance
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