scholarly journals Humanized CD22 transgenic mouse model for in vivo analysis of anti‐CD22‐based immunotherapy

2020 ◽  
Vol 50 (11) ◽  
pp. 1834-1837
Author(s):  
Carolin Brandl ◽  
Sieglinde Angermüller ◽  
Lars Nitschke
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
In Vivo Analysis

scholarly journals In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

2018 ◽  
Vol 17 (5) ◽  
pp. 590-600 ◽  
Author(s):  
Polina A. Egorova ◽  
Alexandra V. Gavrilova ◽  
Ilya B. Bezprozvanny
Keyword(s):  
Mouse Model ◽  
Purkinje Cell ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Climbing Fiber ◽  
In Vivo Analysis ◽  
Cell Circuit

scholarly journals Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer

2015 ◽  
Vol 18 (4) ◽  
pp. 617-626 ◽  
Author(s):  
Jean-Louis Alberini ◽  
Raphaël Boisgard ◽  
Stéphanie Guillermet ◽  
Karine Siquier ◽  
Benoît Jego ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
In Vivo Imaging ◽  
Mammary Cancer ◽  
Transgenic Mouse Model ◽  
Response To Chemotherapy

scholarly journals In Vivo Monitoring of Pancreatic β-Cells in a Transgenic Mouse Model

2006 ◽  
Vol 5 (2) ◽  
pp. 7290.2006.00007 ◽  
Author(s):  
Steven J. Smith ◽  
Hongbing Zhang ◽  
Anne O. Clermont ◽  
Alvin C. Powers ◽  
Dixon B. Kaufman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
In Vivo Monitoring

In Vivo Imaging of Lymph Node Migration of MNP- and 111In-Labeled Dendritic Cells in a Transgenic Mouse Model of Breast Cancer (MMTV-Ras)

2011 ◽  
Vol 14 (2) ◽  
pp. 183-196 ◽  
Author(s):  
Cristina Martelli ◽  
Manuela Borelli ◽  
Luisa Ottobrini ◽  
Veronica Rainone ◽  
Anna Degrassi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
In Vivo Imaging ◽  
Transgenic Mouse Model

scholarly journals PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

Blood ◽  
2011 ◽  
Vol 117 (7) ◽  
pp. 2241-2246 ◽  
Author(s):  
Michael P. Reilly ◽  
Uma Sinha ◽  
Pierrette André ◽  
Scott M. Taylor ◽  
Yvonne Pak ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Immune Complex ◽  
Transgenic Mouse Model ◽  
Control Group ◽  
Platelet Factor ◽  
Heparin Induced Thrombocytopenia ◽  
Syk Inhibitor ◽  
Induced Aggregation

AbstractHeparin-induced thrombocytopenia (HIT) is a major cause of morbidity and mortality resulting from the associated thrombosis. Extensive studies using our transgenic mouse model of HIT have shown that antibodies reactive with heparin-platelet factor 4 complexes lead to FcγRIIA-mediated platelet activation in vitro as well as thrombocytopenia and thrombosis in vivo. We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT.

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