scholarly journals Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice

2016 ◽  
Vol 46 (5) ◽  
pp. 1119-1131 ◽  
Author(s):  
Takeshi Kawabe ◽  
Nobu Suzuki ◽  
Satoshi Yamaki ◽  
Shu-lan Sun ◽  
Atsuko Asao ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Th17 Cell ◽  
Cell Generation ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals Culture-Independent Analysis of Indomethacin-Induced Alterations in the Rat Gastrointestinal Microbiota

2006 ◽  
Vol 72 (10) ◽  
pp. 6707-6715 ◽  
Author(s):  
Andrew B. Dalby ◽  
Daniel N. Frank ◽  
Allison L. St. Amand ◽  
Alison M. Bendele ◽  
Norman R. Pace
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Small Subunit ◽  
Rrna Genes ◽  
Small Subunit Rrna ◽  
Mesenteric Lymph Nodes ◽  
Gastrointestinal Microbiota ◽  
Mesenteric Lymph ◽  
Independent Analysis ◽  
Culture Independent

ABSTRACT Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for a variety of inflammatory conditions; however, the benefits of this class of drugs are accompanied by deleterious side effects, most commonly gastric irritation and ulceration. NSAID-induced ulceration is thought to be exacerbated by intestinal microbiota, but previous studies have not identified specific microbes that contribute to these adverse effects. In this study, we conducted a culture-independent analysis of ∼1,400 bacterial small-subunit rRNA genes associated with the small intestines and mesenteric lymph nodes of rats treated with the NSAID indomethacin. This is the first molecular analysis of the microbiota of the rat small intestine. A comparison of clone libraries and species-specific quantitative PCR results from rats treated with indomethacin and untreated rats revealed that organisms closely related to Enterococcus faecalis were heavily enriched in the small intestine and mesenteric lymph nodes of the treated rats. These data suggest that treatment of NSAID-induced ulceration may be facilitated by addressing the microbiological imbalances.

Rotavirus A associated pathology of intestine and mesenteric lymph nodes and occurrence in bovine calves of Gwalior and Bareilly regions

2018 ◽  
Author(s):  
Gayatri Kashyap ◽  
R. Singh ◽  
Y. S. Malik ◽  
R. K. Agrawal ◽  
K. P. Singh ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Mononuclear Cells ◽  
Dairy Farm ◽  
Rt Pcr ◽  
Mesenteric Lymph Nodes ◽  
Fecal Samples ◽  
Rotavirus A ◽  
Mesenteric Lymph ◽  
Vp6 Gene

To understand the pathology of natural cases of rotavirus (RVA) in bovine calves, a total of 40 cases below 6 months died due to diarrhoea were studied, out of which 7 cases (17.5%) turned positive for RVA by RT-PCR. Histopathology of small intestine showed loss of villous enterocytes, blunting and fusion of villi, elongation of crypts and mononuclear cells infiltration in the lamina-propria. The mesenteric lymph nodes were severely depleted of lymphocytes. These changes were corroborated with presence of RVA antigen in sections by dFAT and nucleic acid by RT-PCR. The fluorescent signals were more in mesenteric lymph nodes than in intestine. Besides, 115 rectal fecal samples were also collected from calves for RVA detection by RT-PCR using VP6 gene specific sets of primers. Dead carcasses of calves (n= 40) belonged to organized dairy farm of Bareilly, while rectal fecal samples belonged to both organized (n= 38) and unorganized farms (n= 77) of Bareilly and Gwalior. The overall occurrence of RVA was 19.3% (30/155), comprising 5/37 cases (13.5%) from Gwalior (MP) and 25/118 cases (21.1%) from Bareilly (UP). These findings suggest the infection of RVA widely prevalent in calves and have potential to escape from the intestinal site to mesenteric lymph nodes.

Quantitative contrast-enhanced ultrasonographic analysis of perfusion in the kidneys, liver, pancreas, small intestine, and mesenteric lymph nodes in healthy cats

2010 ◽  
Vol 71 (11) ◽  
pp. 1305-1311 ◽  
Author(s):  
Merja R. Leinonen ◽  
Marja R. Raekallio ◽  
Outi M. Vainio ◽  
Mirja O. Ruohoniemi ◽  
David S. Biller ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Contrast Enhanced

scholarly journals Lipogranulomatous Lymphangitis in Canine Intestinal Lymphangiectasia

1984 ◽  
Vol 21 (4) ◽  
pp. 377-383 ◽  
Author(s):  
H. J. Van Kruiningen ◽  
G. E. Lees ◽  
D. W. Hayden ◽  
D. J. Meuten ◽  
W. A. Rogers
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Chronic Diarrhea ◽  
Intestinal Lymphangiectasia ◽  
Mesenteric Lymph Nodes ◽  
Protein Losing Enteropathy ◽  
Mesenteric Lymph

Lipogranulomatous lymphangitis of the intestine occurred in four dogs with intestinal lymphangiectasia. All four presented with chronic diarrhea; three had ascites and two had hypoalbuminemia. Lipogranulomas appeared in lymphatics, often at the point of mesenteric attachment, of small intestine, ileum, or ileum and colon. Mesenteric lymphatics were obstructed and villous lacteals were distended. Mesenteric lymph nodes of one dog contained large lipid spaces and that same animal had a solitary subcapsular lipogranuloma of the liver. This disorder is one of several that result in protein-losing enteropathy in dogs.

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183
Author(s):  
Hisashi Kobayashi ◽  
Hiroshi Nagata ◽  
Soichiro Miura ◽  
Toshifumi Azuma ◽  
Hidekazu Suzuki ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes

Medicine ◽  
2017 ◽  
Vol 96 (42) ◽  
pp. e7934 ◽  
Author(s):  
Ping Wang ◽  
Quan Li ◽  
Li Zhang ◽  
Hong Ji ◽  
Cheng-Zhou Zhang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Myeloid Sarcoma ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE

1974 ◽  
Vol 139 (5) ◽  
pp. 1189-1203 ◽  
Author(s):  
Philip B. Carter ◽  
Frank M. Collins
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Large Intestine ◽  
Salmonella Enteritidis ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Enteric Infection ◽  
Mesenteric Lymph Nodes ◽  
Ileal Mucosa ◽  
Mesenteric Lymph

This study followed the early pathogenesis of orally induced murine typhoid fever. Intragastrically administered Salmonella enteritidis moves quickly through the normal undisturbed gut so that only a small residuum remains in the cecum and large intestine after the first few hours. Dye injection of the gut wall was used to show that lymph from discrete portions of the gastrointestinal tract drains to separate lymph nodes, probably via the regional Peyer's patches. Plating techniques capable of detecting a single colony-forming unit of S. enteritidis within the different Peyer's patches and draining lymph nodes indicate that, although the cecum and large intestine are exposed to large numbers of Salmonella for longer time periods than the small intestine, the primary site of bacterial penetration involves the distal ileum. This area of the small intestine as well as the cecum are both drained by the distal mesenteric lymph nodes, and were the only nodes which contained detectable numbers of viable Salmonella over the first 24 h of infection. Neither the pyloric nor the proximal mesenteric lymph nodes (which drain the stomach and duodenum) nor the pancreatic and caudal lymph nodes (which drain the transverse and descending colon) contained viable Salmonella. Salmonella were observed to infect the ileal mucosa and its Peyer's patches. With time, this infection progresses to the draining lymph node and ultimately reaches the liver and spleen. Some of the implications of these findings relative to the development of acquired resistance to enteric disease are discussed.

scholarly journals Comparison of pathological changes in the study of dogs affected by parvoviral enteritis and intestinal yersiniosis

2021 ◽  
pp. 102-110
Author(s):  
Hryhorii Zon ◽  
Lyudmyla Ivanovska ◽  
Illia Zon ◽  
Tion Matthew Terzungwe
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Large Intestine ◽  
Definitive Diagnosis ◽  
Lung Damage ◽  
Sufficient Evidence ◽  
Pathological Findings ◽  
Pathological Changes ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

Aim of the study: to examine the pathological changes in dogs that died due to confirmed intestinal yersiniosis and parvoviral enteritis and establish trends for characteristic organ lesions for both diseases in comparison, then evaluate our findings with the existing published material of sufficient evidence quality regarding differential postmortem diagnosis of spontaneous intestinal yersiniosis and parvoviral enteritis in dogs. Materials and methods: the study examined the cases of 25 dogs from 2 month to 1.3 y.o. of various breed, gender that died due to either confirmed Canine parvoviral enteritis (CPV) infection or intestinal yersiniosis and subsequently divided into two groups based on their diagnosis. The definitive diagnosis has been confirmed by performing rapid ELISA diagnostics (SensPERT®, VetAll Laboratories, Kyunggi-Do, Korea) for CPV and serological tests for Y. enterocolitica sera AT were performed using yersiniosis antigens from the "Component set for serological diagnosis of animal yersiniosis" (Kharkiv, NSC IEKVM, TS 46.15.091-95) in accordance with the "Interim guidelines for the use of a set of components for serological diagnostics". A dilution of 1: 200 has been considered as the diagnostic titer. After the definitive diagnosis had been confirmed, the animals were divided into two groups, depending on diagnosis: CPV (n=14) or IY (n=11). The autopsies of twenty randomly (10 from each group) selected dog corpses have been conducted utilizing standard methodology. Results: according to the results of autopsy of dogs afflicted by CPV, the main pathological changes were found in the small intestine – catarrhal-desquamative inflammation (in 100 % of cases), serous-hemorrhagic mesenteric lymphadenitis (90 %) large intestine (70 %) in the stomach (60 %), in the liver (50 %), in other organs – less than 40 percent of cases and most notably caused lung damage (edema and local atelectasis) in 90 % of the animals in the study, which was not the case for intestinal yersiniosis with only 20 % incidence of lung damage. Conclusions: Spontaneous intestinal yersiniosis in dogs was pathologically manifested by pronounced catarrhal-desquamative processes mainly in the stomach and small intestine (70, 100 and 80 % of cases, respectively), inflammation of the mesenteric lymph nodes (90 %) and large intestine (80 %), dystrophy and congestive processes in the liver (80 %). Low incidence and type of lung damage (congestive hyperemia in 20 % of reviewed cases compared to 90 % of local atelectasis add edema in CPV group) was noteworthy. Cases of 25 animals that died due to either confirmed CPV or Y. enterocolitica infection were analyzed, and 20 animal corpses were autopsied during study. Dogs that died from intestinal yersiniosis had significantly higher frequency of pathological findings in kidney (200 %) and liver (60 %) in particular. Changes in stomach and large intestine were also more frequent. At the same time, we observed a lower frequency of pathological changes in spleen (33 % lower), heart (25 % lower) and the lowest frequency was in lungs (77 % lower) presented by edema and local atelectasis in animals afflicted by yersiniosis compared to CPV. Incidence and manifestation of pathological findings was mesenteric lymph nodes and abdominal cavity were similar, and could not be considered during posthumous diagnostics.

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