scholarly journals Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus

2015 ◽  
Vol 45 (8) ◽  
pp. 2409-2419 ◽  
Author(s):  
Louise D. Fraser ◽  
Yuan Zhao ◽  
Pamela M. K. Lutalo ◽  
David P. D'Cruz ◽  
John Cason ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Immunoglobulin Light Chain ◽  
Systemic Lupus

Comparable heavy and light chain pairings in normal and systemic lupus erythematosus IgG+ B cells

2000 ◽  
Vol 30 (1) ◽  
pp. 254-261 ◽  
Author(s):  
Ruud M. T. de Wildt ◽  
Ian M. Tomlinson ◽  
Walther J. van Venrooij ◽  
Greg Winter ◽  
René M. A. Hoet
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Systemic lupus erythematosus: molecular cloning and analysis of recombinant DNase monoclonal   light chain NGK-1

2014 ◽  
Vol 26 (8) ◽  
pp. 439-450 ◽  
Author(s):  
I. A. Kostrikina ◽  
E. S. Odintsova ◽  
V. N. Buneva ◽  
G. A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Molecular Cloning ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers

2016 ◽  
Vol 12 (12) ◽  
pp. 3556-3566 ◽  
Author(s):  
Anna M. Timofeeva ◽  
Valentina N. Buneva ◽  
Georgy A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myelin Basic Protein ◽  
Molecular Cloning ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Kappa Light Chain ◽  
Systemic Lupus ◽  
Active Centers

Monoclonal light chain (NGTA1-Me-pro) possessing two alternative active centers with metalloprotease activities specifically recognizing only myelin basic protein (MBP) was obtained. NGTA1-Me-pro demonstrated two pH optima (A), two optimal concentrations of Me2+ions (B), and twoKmvalues for MBP.

Clinical relapse in systemic lupus erythematosus: Correlation with antecedent elevation of urinary free light-chain immunoglobulin

1989 ◽  
Vol 9 (4) ◽  
pp. 338-350 ◽  
Author(s):  
John E. Hopper ◽  
Winston Sequeira ◽  
Joan Martellotto ◽  
Elaine Papagiannes ◽  
Laura Perna ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Free Light Chain ◽  
Clinical Relapse ◽  
Systemic Lupus ◽  
Light Chain Immunoglobulin

scholarly journals Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti–Single-Stranded DNA Transgenic Mrl/lpr Mice

1999 ◽  
Vol 190 (5) ◽  
pp. 691-704 ◽  
Author(s):  
Frederic Brard ◽  
Michele Shannon ◽  
Eline Luning Prak ◽  
Samuel Litwin ◽  
Martin Weigert
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
Somatic Mutation ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Direct Evidence ◽  
Cell Nuclei ◽  
Systemic Lupus ◽  
Double Stranded Dna

Antibodies to single-stranded (ss)DNA are expressed in patients with systemic lupus erythematosus and in lupus-prone mouse models such as the MRL/Mp-lpr/lpr (MRL/lpr) strain. In nonautoimmune mice, B cells bearing immunoglobulin site-directed transgenes (sd-tgs) that code for anti-ssDNA are functionally silenced. In MRL/lpr autoimmune mice, the same sd-tgs are expressed in peripheral B cells and these autoantibodies gain the ability to bind other autoantigens such as double-stranded DNA and cell nuclei. These new specificities arise by somatic mutation of the anti-ssDNA sd-tgs and by secondary light chain rearrangement. Thus, B cells that in normal mice are anergic can be activated in MRL/lpr mice, which can lead to the generation of pathologic autoantibodies. In this paper, we provide the first direct evidence for peripheral rearrangement in vivo.

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