Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice

2015 ◽  
Vol 45 (10) ◽  
pp. 2821-2833 ◽  
Author(s):  
Karina A. Pasquevich ◽  
Kristin Bieber ◽  
Manina Günter ◽  
Matthias Grauer ◽  
Oliver Pötz ◽  
...  
Keyword(s):  
Immune System ◽  
Bacterial Infection ◽  
Innate Immune System ◽  
Innate Immune ◽  
Systemic Bacterial Infection

Arming the enemy: the evolution of resistance to self-proteins

Microbiology ◽  
2003 ◽  
Vol 149 (6) ◽  
pp. 1367-1375 ◽  
Author(s):  
Graham Bell ◽  
Pierre-Henri Gouyon
Keyword(s):  
Immune System ◽  
Bacterial Infection ◽  
Innate Immune System ◽  
Membrane Structure ◽  
Innate Immune ◽  
Bacterial Membrane ◽  
Evolution Of Resistance ◽  
Defence Proteins ◽  
Toxic Peptides ◽  
Novel Antibiotics

A remarkable range of novel antibiotics is attracting increasing interest as a major new weapon in the campaign against bacterial infection. They are based on the toxic peptides that provide the innate immune system of animals, and it is claimed that bacteria will be unable to evolve resistance to them because they attack the ‘Achilles' heel’ of bacterial membrane structure. Both experimental evidence and theoretical arguments suggest that this claim is doubtful. If so, the introduction of these substances into general use may provoke the evolution of resistance to our own defence proteins and thus compromise our natural defences against infection.

scholarly journals Neutrophils and Bacterial Immune Evasion

2018 ◽  
Vol 10 (5-6) ◽  
pp. 432-441 ◽  
Author(s):  
Scott D. Kobayashi ◽  
Natalia Malachowa ◽  
Frank R. DeLeo
Keyword(s):  
Immune System ◽  
Bacterial Infection ◽  
Immune Evasion ◽  
Bactericidal Activity ◽  
Innate Immune System ◽  
Bacterial Pathogens ◽  
Neutrophil Recruitment ◽  
Innate Immune ◽  
Front Line ◽  
And Function

Neutrophils are an important component of the innate immune system and provide a front line of defense against bacterial infection. Although most bacteria are killed readily by neutrophils, some bacterial pathogens have the capacity to circumvent destruction by these host leukocytes. The ability of bacterial pathogens to avoid killing by neutrophils often involves multiple attributes or characteristics, including the production of virulence molecules. These molecules are diverse in composition and function, and collectively have the potential to alter or inhibit neutrophil recruitment, phagocytosis, bactericidal activity, and/or apoptosis. Here, we review the ability of bacteria to target these processes.

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