Micro-RNA-155-mediated control of heme oxygenase 1 (HO-1) is required for restoring adaptively tolerant CD4+T-cell function in rodents

2015 ◽  
Vol 45 (3) ◽  
pp. 829-842 ◽  
Author(s):  
Jinyu Zhang ◽  
Patricia Vandevenne ◽  
Haifa Hamdi ◽  
Merry Van Puyvelde ◽  
Alessandro Zucchi ◽  
...  
Keyword(s):  
T Cell ◽  
Heme Oxygenase ◽  
Cell Function ◽  
Micro Rna ◽  
Cd4 T Cell ◽  
Heme Oxygenase 1 ◽  
T Cell Function

scholarly journals Eomesodermin regulate decidual CD4+T cell function during human early pregnancy

2021 ◽  
pp. 103290
Author(s):  
Lanting Chen ◽  
Mengdie Li ◽  
Fengrun Sun ◽  
Jinfeng Qian ◽  
Meirong Du ◽  
...  
Keyword(s):  
T Cell ◽  
Early Pregnancy ◽  
Cell Function ◽  
Cd4 T Cell ◽  
T Cell Function

Abstract 760: Heme Oxygenase-1 expression in Dendritic Cells determines the Outcome of Transplantation Arteriosclerosis

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Annemarie Noordeloos ◽  
Elza van Deel ◽  
Denise Hermes ◽  
Maarten L Simoons ◽  
Dirk J Duncker ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Heme Oxygenase ◽  
T Cell Activation ◽  
Neointimal Hyperplasia ◽  
Cd4 T Cell ◽  
Cell Infiltration ◽  
Heme Oxygenase 1 ◽  
T Cell Infiltration ◽  
Mhcii Expression

Introduction: Although expression of heme oxygenase-1 (HO1) attenuates transplantation arteriosclerosis, the mechanism by which HO1 exerts its protective effect remains unclear. We studied the effect of HO1-deficient vs. wildtype (WT) dendritic cells (DCs) on the T-cell priming response and outcome in a murine transplant arteriosclerosis model. Methods: At day 0 C57bl6 mice received either WT (n=6) or HO1-knockout DCs (n=6) pre-sensitized with Balb/c splenocytes lysate to accelerate the development of arteriosclerosis. At day 10 an aorta segment from Balb/c mice was transplanted into the carotid artery position of C57Bl6 mice.14 days after transplantation allografts were excised and processed for immunohistochemical analysis. Results: HO1-deficient DCs significantly increased neointimal hyperplasia as compared to WT DCs (116995 vs. 46114μm 2 P<0.05) and incidence of intima formation (83 vs. 50% in WT DC). HO1 deficient DCs also increased medial thickeness (15936 vs.12034 μm 2 P<0.05) and intimal VSMCs content (76 vs. 46% P<0.05) and resulted in more prominent medial cell infiltration (461μm 2 vs. 232μm 2 P<0.05). Although HO1 deficient and WT DCs could be detected in allografts, HO1-nullizygous DCs induced an increase in CD4+ T-cell infiltration (9.5 vs. 0.1% in WT P<0.05) concomitant to a decrease of CD8+ T cell infiltration (8 vs.14%, P<0.05). In line with these observations Affymetrix microarray analysis confirmed that HO1 deletion in DCs was associated with a significant downregulation of MHCII-H2A expression (associated with CD4+T-cell activation) and induction of inhibitors of MHCII expression (including IK protein) whereas MHC I expression remained unchanged. Conclusions: HO1 expression in dendritic cells increases vascular cell infiltration with a higher CD8+/CD4+ T-cell ratio by stabilizing MHCII expression in vascular allografts resulting in inhibition of neointima formation and hence improved allograft survival.

Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell Function

2007 ◽  
Vol 13 (7) ◽  
pp. 2158-2167 ◽  
Author(s):  
Peter E. Fecci ◽  
Hidenobu Ochiai ◽  
Duane A. Mitchell ◽  
Peter M. Grossi ◽  
Alison E. Sweeney ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Cd4 T Cell ◽  
Cell Compartment ◽  
T Cell Function ◽  
Induced Changes

scholarly journals A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function

Retrovirology ◽  
2014 ◽  
Vol 11 (1) ◽  
pp. 57 ◽  
Author(s):  
Evan S Jacobs ◽  
Desmond Persad ◽  
Longsi Ran ◽  
Ali Danesh ◽  
John W Heitman ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Cd4 T Cell ◽  
Signaling Proteins ◽  
T Cell Function ◽  
Inhibitory Signaling

scholarly journals Modulation of CD4 T cell function via CD6-targeting

EBioMedicine ◽  
2019 ◽  
Vol 47 ◽  
pp. 427-435 ◽  
Author(s):  
Raquel Filipa Freitas ◽  
Afonso Basto ◽  
Silvia C.P. Almeida ◽  
Rita F. Santos ◽  
Carine M. Gonçalves ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Cd4 T Cell ◽  
T Cell Function

P0161 PP CD4+CD25+ T REGS MAINTAIN THE ABILITY TO SUPPRESS CD4 T CELL FUNCTION IN PATIENTS WITH AUTOIMMUNE LIVER DISEASE

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S119-S120
Author(s):  
M. S. Longhi ◽  
Y. Ma ◽  
D. P. Bogdanos ◽  
G. Mieli-Vergani ◽  
D. Vergani
Keyword(s):  
Liver Disease ◽  
T Cell ◽  
Cell Function ◽  
Autoimmune Liver Disease ◽  
Cd4 T Cell ◽  
T Cell Function

scholarly journals HIV Patients Developing Primary CNS Lymphoma Lack EBV-Specific CD4+ T Cell Function Irrespective of Absolute CD4+ T Cell Counts

PLoS Medicine ◽  
2007 ◽  
Vol 4 (3) ◽  
pp. e96 ◽  
Author(s):  
Olivier Gasser ◽  
Florian K Bihl ◽  
Marcel Wolbers ◽  
Elisabetta Loggi ◽  
Ingrid Steffen ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Primary Cns Lymphoma ◽  
Cd4 T Cell ◽  
Cns Lymphoma ◽  
Hiv Patients ◽  
Cell Counts ◽  
T Cell Function

scholarly journals Evaluation of CD4+T Cell Function In Vivo in HIV‐Infected Patients as Measured by Bacteriophage phiX174 Immunization

2000 ◽  
Vol 182 (2) ◽  
pp. 435-441 ◽  
Author(s):  
Ilana Fogelman ◽  
Victoria Davey ◽  
Hans D. Ochs ◽  
Michael Elashoff ◽  
Mark B. Feinberg ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Cd4 T Cell ◽  
T Cell Function ◽  
Bacteriophage Phix174

HBV variants create “altered peptide ligands” which results in altered CD4+ T-cell function

1998 ◽  
Vol 28 ◽  
pp. 50
Author(s):  
M.-C. Jung ◽  
J.T. Gerlach ◽  
T. Santantonio ◽  
H. Diepolder ◽  
E. Wierenga ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Peptide Ligands ◽  
Cd4 T Cell ◽  
Altered Peptide Ligands ◽  
T Cell Function ◽  
Hbv Variants
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