STAT of the union: Dynamics of distinct tumor-associated macrophage subsets governed by STAT1

2014 ◽  
Vol 44 (8) ◽  
pp. 2238-2242 ◽  
Author(s):  
Eva Van Overmeire ◽  
Damya Laoui ◽  
Jiri Keirsse ◽  
Stefano Bonelli ◽  
Qods Lahmar ◽  
...  
Keyword(s):  
Tumor Associated Macrophage ◽  
Union Dynamics ◽  
Macrophage Subsets

scholarly journals Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients

2021 ◽  
Author(s):  
Rodrigo Nalio Ramos ◽  
Yoann Missolo-Koussou ◽  
Yohan Gerber-Ferder ◽  
Christian Bromley ◽  
Mattia Bugatti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cancer Progression ◽  
Patient Survival ◽  
Macrophage Infiltration ◽  
Therapeutic Interventions ◽  
Breast Cancer Patients ◽  
Tumor Associated Macrophages ◽  
Tumor Associated Macrophage ◽  
Macrophage Subsets

SUMMARYMacrophage infiltration is a hallmark of solid cancers and overall macrophage infiltration is correlated with lower patient survival and resistance to therapy. However, tumor-associated macrophages are phenotypically and functionally heterogeneous. Specific tumor-associated macrophage subsets might be endowed with antagonistic role on cancer progression and on the development of anti-tumor immunity. For instance, monocyte-derived TREM2+ tumor-associated macrophages have pro-tumorigenic and immunosuppressive functions. Here, we identify a discrete population of FOLR2+ tumor-associated macrophages positively correlating with patient survival in breast cancer. FOLR2+ macrophages are evolutionarily conserved across species and populate human and murine healthy mammary gland. Moreover, FOLR2+ macrophages co-localize with lymphoid aggregates containing CD8+ T cells in breast cancer and across ten other types of cancers. This study highlights antagonistic roles for tumor-associated macrophage subsets and paves the way for subset-specific therapeutic interventions in macrophages-based cancer therapies.

Abstract B26: Identification of molecular and functional differences in tumor-associated macrophage subsets

2013 ◽  
Author(s):  
Esther N. Arwert ◽  
Allison S. Harney ◽  
David Entenberg ◽  
Yarong Wang ◽  
Jeffrey W. Pollard ◽  
...  
Keyword(s):  
Tumor Associated Macrophage ◽  
Functional Differences ◽  
Macrophage Subsets

scholarly journals Identification of tumor‐associated macrophage subsets that are associated with breast cancer prognosis

2020 ◽  
Vol 10 (8) ◽  
Author(s):  
Elisabeth Strack ◽  
P. Alexander Rolfe ◽  
Annika F. Fink ◽  
Katrin Bankov ◽  
Tobias Schmid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Tumor Associated Macrophage ◽  
Macrophage Subsets

MACROPHAGE SUBSETS AND MESENCHYMAL STEM CELLS IN REGULATION OF BONE TISSUE REMODELING

Tsitologiya ◽  
2018 ◽  
Vol 6o (4) ◽  
pp. 252-261 ◽  
Author(s):  
E.E. Ivanyuk ◽  
◽  
S.V. Nadezhdin ◽  
L.A. Pokrovskaya ◽  
V.V. Shupletsova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue ◽  
Tissue Remodeling ◽  
Bone Tissue Remodeling ◽  
Macrophage Subsets
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