scholarly journals PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE

2014 ◽  
Vol 44 (8) ◽  
pp. 2287-2294 ◽  
Author(s):  
Karthik Sathiyanadan ◽  
Caroline Coisne ◽  
Gaby Enzmann ◽  
Urban Deutsch ◽  
Britta Engelhardt
Keyword(s):  
T Cell ◽  
Cell Rolling

Distinct characteristics of T cell rolling and adhesion in splenic versus lymph node vessels

2002 ◽  
Vol 109 (1) ◽  
pp. S318-S318
Author(s):  
Mitchell H Grayson ◽  
Michael J Holtzman ◽  
David D Chaplin
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Cell Rolling

αL-Integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium

2005 ◽  
Vol 288 (1) ◽  
pp. G67-G73 ◽  
Author(s):  
Meng Huang ◽  
Kametra Matthews ◽  
Teruna J. Siahaan ◽  
Christopher G. Kevil
Keyword(s):  
T Cells ◽  
Cell Adhesion ◽  
T Cell ◽  
Cell Surface ◽  
Pancreatic Islet ◽  
Cyclic Peptide ◽  
Monocyte Adhesion ◽  
Cell Rolling ◽  
Tnf Α ◽  
Islet Endothelium

Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet β-cell destruction. We examined integrin requirements and specific inhibition of integrin structure in T cell and monocyte adhesion to pancreatic islet endothelium. Examination of cell surface integrin expression on WEHI 7.1 T cells revealed prominent expression of β-, β1-, αL-integrins, and low expression of αM-integrins; whereas WEHI 274.1 monocytes showed significant staining for β2-, β1-, αM-molecules and no expression of αL-molecules. Unstimulated islet endothelium showed constitutive levels of ICAM-1 counter-ligand expression with minimal VCAM-1 expression; however, TNF-α stimulation increased cell surface density of both molecules. TNF-α increased T cell and monocyte rolling and adhesion under hydrodynamic flow conditions. Administration of a cyclic peptide competitor for the αL-integrin I domain binding sites (cyclo1,12-PenITDGEATDSGC) blocked T cell adhesion without inhibiting monocyte adhesion. Examination of T cell rolling revealed that cLAB.L treatment increased the average rolling velocity on activated endothelium and significantly decreased the fraction of T cells rolling at ≤50 μm/s, suggesting that cLAB.L treatment interferes with signal activation events required for the conversion of T cell rolling to firm adhesion. These data demonstrate for the first time that cyclic peptide antagonists against αL-integrin I domain attenuate T cell recruitment to islet endothelium.

Selectins, T-cell rolling and inflammation

1997 ◽  
Vol 3 (5) ◽  
pp. 214-222 ◽  
Author(s):  
Heidemaric Rossiter ◽  
Ronen Alon ◽  
Thomas S. Kupper
Keyword(s):  
T Cell ◽  
Cell Rolling

Electron microscope study of the secretory activity of epithelial cells in embryonic thymus

1990 ◽  
Vol 48 (3) ◽  
pp. 382-383
Author(s):  
H. Alasam
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Epithelial Cells ◽  
Electron Density ◽  
Secretory Activity ◽  
T Cell Differentiation ◽  
High Electron ◽  
Transmission Electron ◽  
Medullary Epithelial Cells ◽  
Thymic Factor

The possibility that intrathymic T-cell differentiation involves stem cell-lymphoid interactions in embryos led us to study the ultrastructure of epithelial cell in normal embryonic thymus. Studies in adult thymus showed that it produces several peptides that induce T-cell differentiation. Several of them have been chemically characterized, such as thymosin α 1, thymopoietin, thymic humoral factor or the serum thymic factor. It was suggested that most of these factors are secreted by populations of A and B-epithelial cells.Embryonic materials were obtained from inbred matings of Swiss Albino mice. Thymuses were disected from embryos 17 days old and prepared for transmission electron microscopy. Our studies showed that embryonic thymus at this stage contains undifferentiated and differentiated epithelial cells, large lymphoblasts, medium and few small lymphocytes (Fig. 5). No differences were found between cortical and medullary epithelial cells, in contrast to the findings of Van Vliet et al,. Epithelial cells were mostly of the A-type with low electron density in both cytoplasm and nucleus. However few B-type with high electron density were also found (Fig. 7).

FAILURE TO DETECT ANTI-HTLV-1 ANTIBODY IN A PATIENT WITH ADULT T-CELL LEUKAEMIA/LYMPHOMA

1998 ◽  
Vol 103 (4) ◽  
pp. 1207-1208 ◽  
Author(s):  
Shan-Shun Luo ◽  
Hideto Tamura ◽  
Norio Yokose ◽  
Kiyoyuki Ogata ◽  
Kazuo Dan
Keyword(s):  
T Cell ◽  
Cell Leukaemia
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