Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+T-cell cross-priming

2014 ◽  
Vol 44 (8) ◽  
pp. 2415-2424 ◽  
Author(s):  
Cynthia M. Fehres ◽  
Sven C. M. Bruijns ◽  
Astrid J. van Beelen ◽  
Hakan Kalay ◽  
Martino Ambrosini ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cd8 T Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Dermal Dendritic Cell ◽  
Tlr7 Ligand

scholarly journals Naive CD8+ T cell recruitment and proliferation are dependent on stage of dendritic cell maturation

2003 ◽  
Vol 33 (1) ◽  
pp. 162-171 ◽  
Author(s):  
Andrew Kaiser ◽  
Nadège Bercovici ◽  
Jean-Pierre Abastado ◽  
Alessandra Nardin
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cd8 T Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Cell Recruitment

scholarly journals TNF Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms

2011 ◽  
Vol 187 (3) ◽  
pp. 1184-1191 ◽  
Author(s):  
Xilai Ding ◽  
Wei Yang ◽  
Xiaodong Shi ◽  
Peishuang Du ◽  
Lishan Su ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
Dendritic Cell Maturation ◽  
T Cell Response ◽  
Cell Maturation ◽  
Tnf Receptor

scholarly journals Dendritic Cell Maturation, but Not CD8+T Cell Induction, Is Dependent on Type I IFN Signaling during Vaccination with Adenovirus Vectors

2005 ◽  
Vol 175 (9) ◽  
pp. 6032-6041 ◽  
Author(s):  
Scott E. Hensley ◽  
Wynetta Giles-Davis ◽  
Kimberly C. McCoy ◽  
Wolfgang Weninger ◽  
Hildegund C. J. Ertl
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cd8 T Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Type I ◽  
Type I Ifn ◽  
Cell Induction ◽  
Adenovirus Vectors

TREM-1 modulates dendritic cell maturation and dendritic cell–mediated T cell activation induced by ox-LDL

2020 ◽  
Author(s):  
Yunkai Wang ◽  
Jie Wang ◽  
Lu Han ◽  
Yun Li Shen ◽  
Jie Yun You ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Peripheral Blood ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Blood Monocytes

Abstract Background: Triggering receptor expressed on myeloid cells (TREM)-1is identified as a major upstream proatherogenic receptor. However, the cellular processes modulated by TREM-1 in the development of atherosclerosis and plaque destabilization has not been fully elucidated. In this study, we investigated the effects of TREM-1 on dendritic cell maturation and dendritic cell–mediated T-cell activation induced by oxidized low-density lipoprotein (ox-LDL) in atherogenesis. Methods: Human peripheral blood monocytes were differentiated to dendritic cells and stimulated by ox-LDL. Naive autologous T cells were co-cultured with pretreated dendritic cells.The expressionof TREM-1 and the production of inflammatory cytokines were assessed by real-time PCR, western blot and ELISA.The expression of immune factors was determined with FACS to evaluate dendritic cell maturation and T-cell activation. Results: Stimulation with ox-LDL promoted dendritic cell maturation, TREM-1 expression and T-cell activation, and exposure of T cells to ox-LDL-treated dendritic cells induced production of interferon-γ and IL-17. Blocking TREM-1 suppressed dendritic cell maturation with low expression of CD1a, CD40, CD86 and HLA-DR, decreased production of TNF-α, IL-1β, IL-6 and MCP-1, and increased secretion of TGF-β and IL-10. In addition, stimulation of ox-LDL induced miR-155, miR-27, Let-7c and miR-185 expression, whereas inhibition of TREM-1 repressed miRNA-155. Silencing TREM-1 or miRNA-155 increased SOCS1 expression induced by ox-LDL. T cells derived from carotid atherosclerotic plaques or healthy individuals showed similar result patterns. Conclusion: These data suggest that TREM-1 modulates maturation of dendritic cells and activation of plaque T cells induced by ox-LDL, a pivotal player in atherogenesis.

scholarly journals CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection

2019 ◽  
Vol 15 (8) ◽  
pp. e1007970 ◽  
Author(s):  
Kai Qin ◽  
Sushma Boppana ◽  
Victor Y. Du ◽  
Jonathan M. Carlson ◽  
Ling Yue ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Hiv Infection ◽  
Cd8 T Cells ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation ◽  
Trans Infection ◽  
Chronic Hiv Infection

scholarly journals Glycodendropeptides stimulate dendritic cell maturation and T cell proliferation: a potential influenza A virus immunotherapy

MedChemComm ◽  
2015 ◽  
Vol 6 (10) ◽  
pp. 1755-1760 ◽  
Author(s):  
Ainhoa Mascaraque ◽  
Wioleta Kowalczyk ◽  
Tahia Fernández ◽  
Francisca Palomares ◽  
Cristobalina Mayorga ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Dendritic Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
T Cell Proliferation ◽  
Flu Vaccine ◽  
Virus Epitope

A GDP displaying the NP366–374 influenza A virus epitope induces an immunostimulatory effect, emerging as a potential flu vaccine.

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