The who's who of T-cell differentiation: Human memory T-cell subsets

2013 ◽  
Vol 43 (11) ◽  
pp. 2797-2809 ◽  
Author(s):  
Yolanda D. Mahnke ◽  
Tess M. Brodie ◽  
Federica Sallusto ◽  
Mario Roederer ◽  
Enrico Lugli
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Human Memory ◽  
T Cell Differentiation ◽  
T Cell Subsets ◽  
Memory T Cell

scholarly journals Effector T Cell Differentiation and Memory T Cell Maintenance Outside Secondary Lymphoid Organs

2006 ◽  
Vol 176 (7) ◽  
pp. 4051-4058 ◽  
Author(s):  
Jagdeep S. Obhrai ◽  
Martin H. Oberbarnscheidt ◽  
Timothy W. Hand ◽  
Lonnette Diggs ◽  
Geetha Chalasani ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Lymphoid Organs ◽  
T Cell Differentiation ◽  
Effector T Cell ◽  
Memory T Cell ◽  
Secondary Lymphoid Organs ◽  
Cell Maintenance

scholarly journals Murine in vitro Memory T Cell Differentiation

BIO-PROTOCOL ◽  
2014 ◽  
Vol 4 (13) ◽  
Author(s):  
Myoungjoo Kim ◽  
Weiming Ouyang ◽  
Will Liao ◽  
Michael Zhang ◽  
Ming Li
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Memory T Cell

scholarly journals TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1

2017 ◽  
Vol 199 (12) ◽  
pp. 4091-4102 ◽  
Author(s):  
Nina Chi Sabins ◽  
Olesya Chornoguz ◽  
Karen Leander ◽  
Fred Kaplan ◽  
Richard Carter ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Cd8 T Cells ◽  
T Cell Differentiation ◽  
Effector Memory ◽  
Memory T Cell

Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis

Blood ◽  
2002 ◽  
Vol 100 (13) ◽  
pp. 4550-4556 ◽  
Author(s):  
Frederique Ponchel ◽  
Ann W. Morgan ◽  
Sarah J. Bingham ◽  
Mark Quinn ◽  
Maya Buch ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Large Population ◽  
Chronic Inflammatory Disease ◽  
T Cell Differentiation ◽  
T Cell Subsets ◽  
Naive T Cells ◽  
Naïve T Cells

Rheumatoid arthritis (RA) is a chronic, inflammatory disease of the synovium of uncertain pathogenesis. A number of phenotypic and functional T-cell defects have been described in RA, including abnormal clonal expansions and suppressed proliferative responses, which suggest a defect in T-cell differentiation. Here, we show that RA patients possess fewer naive CD4+ T cells than healthy controls. Furthermore, a smaller proportion of these cells contains a T-cell receptor excision circle (TREC). Patients with RA also have unusual populations of T cells. These include immature cells characterized as CD45RBbrightCD45RA+CD62L− by flow cytometry and a large population that coexpresses CD45RA and CD45RO. These cells are hyperresponsive to mitogen and TCR stimulation when compared to naive cells. Additionally, an unusual putative central memory subset expressing CD62L, but not CD45RA, appears in RA patients at the expense of more typical cells. Levels of C-reactive protein correlate inversely with the TREC content of naive T cells and positively with the sizes of naive and immature atypical T-cell subsets. These data suggest that inflammation drives proliferation of naive T cells in RA and encourages their differentiation into atypical, hyperresponsive progeny. TREC content of individual naive and atypical T-cell subsets suggests an ontogeny consistent with this hypothesis. These studies provide further evidence of a T-cell differentiation defect in RA, which could explain some of the well-characterized immunologic features of the disease.

Naïve to memory T-cell differentiation during homeostasis-driven proliferation

2002 ◽  
Vol 4 (5) ◽  
pp. 555-558 ◽  
Author(s):  
Qing Ge ◽  
Hui Hu ◽  
Herman N. Eisen ◽  
Jianzhu Chen
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Memory T Cell

scholarly journals miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

Cell Reports ◽  
2019 ◽  
Vol 28 (8) ◽  
pp. 2169-2181.e4 ◽  
Author(s):  
John D. Gagnon ◽  
Robin Kageyama ◽  
Hesham M. Shehata ◽  
Marlys S. Fassett ◽  
Darryl J. Mar ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Memory T Cell

scholarly journals SnapShot: Effector and Memory T Cell Differentiation

Cell ◽  
2009 ◽  
Vol 138 (3) ◽  
pp. 606.e1-606.e2 ◽  
Author(s):  
Matthew E. Pipkin ◽  
Anjana Rao
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Memory T Cell

scholarly journals Effector and memory T-cell differentiation: implications for vaccine development

2002 ◽  
Vol 2 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Susan M. Kaech ◽  
E. John Wherry ◽  
Rafi Ahmed
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Vaccine Development ◽  
T Cell Differentiation ◽  
Memory T Cell

scholarly journals Epitope Density Influences CD8+ Memory T Cell Differentiation

PLoS ONE ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. e13740 ◽  
Author(s):  
Julie Leignadier ◽  
Nathalie Labrecque
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Memory T Cell ◽  
Epitope Density
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