scholarly journals Mycobacterium tuberculosis-specific CD8+T cells are functionally and phenotypically different between latent infection and active disease

2013 ◽  
Vol 43 (6) ◽  
pp. 1568-1577 ◽  
Author(s):  
Virginie Rozot ◽  
Selena Vigano ◽  
Jesica Mazza-Stalder ◽  
Elita Idrizi ◽  
Cheryl L. Day ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd8 T Cells ◽  
Latent Infection ◽  
Active Disease

scholarly journals Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5528 ◽  
Author(s):  
Nadia Caccamo ◽  
Giuliana Guggino ◽  
Serena Meraviglia ◽  
Giuseppe Gelsomino ◽  
Paola Di Carlo ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd8 T Cells ◽  
Latent Infection ◽  
Active Tuberculosis

scholarly journals Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset

2015 ◽  
Vol 11 (3) ◽  
pp. e1004671 ◽  
Author(s):  
Krista E. van Meijgaarden ◽  
Mariëlle C. Haks ◽  
Nadia Caccamo ◽  
Francesco Dieli ◽  
Tom H. M. Ottenhoff ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cell Subset ◽  
T Cell Subset ◽  
Human T Cell

scholarly journals Impaired Degranulation and Proliferative Capacity of Mycobacterium tuberculosis–Specific CD8+ T Cells in HIV-Infected Individuals With Latent Tuberculosis

2014 ◽  
Vol 211 (4) ◽  
pp. 635-640 ◽  
Author(s):  
Ameeta S. Kalokhe ◽  
Toidi Adekambi ◽  
Chris C. Ibegbu ◽  
Susan M. Ray ◽  
Cheryl L. Day ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd8 T Cells ◽  
Latent Tuberculosis ◽  
Proliferative Capacity

scholarly journals The emergence of latent infection in the early evolution of Mycobacterium tuberculosis

2016 ◽  
Vol 283 (1831) ◽  
pp. 20160499 ◽  
Author(s):  
Rebecca H. Chisholm ◽  
Mark M. Tanaka
Keyword(s):  
Mathematical Model ◽  
Immune Response ◽  
Mycobacterium Tuberculosis ◽  
Genetic Variation ◽  
Natural Selection ◽  
Natural History ◽  
Latent Infection ◽  
Human Populations ◽  
Safe Harbour ◽  
Active Disease

Mycobacterium tuberculosis has an unusual natural history in that the vast majority of its human hosts enter a latent state that is both non-infectious and devoid of any symptoms of disease. From the pathogen perspective, it seems counterproductive to relinquish reproductive opportunities to achieve a détente with the host immune response. However, a small fraction of latent infections reactivate to the disease state. Thus, latency has been argued to provide a safe harbour for future infections which optimizes the persistence of M. tuberculosis in human populations. Yet, if a pathogen begins interactions with humans as an active disease without latency, how could it begin to evolve latency properties without incurring an immediate reproductive disadvantage? We address this question with a mathematical model. Results suggest that the emergence of tuberculosis latency may have been enabled by a mechanism akin to cryptic genetic variation in that detrimental latency properties were hidden from natural selection until their expression became evolutionarily favoured.

scholarly journals HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Melanie J. Harriff ◽  
Lisa M. Wolfe ◽  
Gwendolyn Swarbrick ◽  
Megan Null ◽  
Meghan E. Cansler ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd8 T Cells

scholarly journals Mycobacterium tuberculosis Multidrug Resistant Strain M Induces an Altered Activation of Cytotoxic CD8+ T Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97837 ◽  
Author(s):  
Laura Geffner ◽  
Juan Ignacio Basile ◽  
Noemí Yokobori ◽  
Denise Kviatcovsky ◽  
Carmen Sabio y García ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd8 T Cells ◽  
Resistant Strain ◽  
Multidrug Resistant ◽  
Multidrug Resistant Strain
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