scholarly journals The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages

2013 ◽  
Vol 43 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Yuan He ◽  
Luigi Franchi ◽  
Gabriel Núñez
Keyword(s):  
Protein Kinase ◽  
Inflammasome Activation ◽  
Inos Production

scholarly journals The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation

2018 ◽  
Vol 138 (6) ◽  
pp. 1380-1390 ◽  
Author(s):  
Gabriele Fenini ◽  
Serena Grossi ◽  
Samuel Gehrke ◽  
Hans-Dietmar Beer ◽  
Takashi K. Satoh ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Inflammasome Activation ◽  
Human Keratinocyte ◽  
Mitogen Activated Protein

scholarly journals PRAK Promotes the Pathogen Clearance by Macrophage Through Regulating Autophagy and Inflammasome Activation

2021 ◽  
Vol 12 ◽  
Author(s):  
Ligu Mi ◽  
Yan Wang ◽  
Hui Xu ◽  
Yu Wang ◽  
Jia Wu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Bacterial Load ◽  
Peritoneal Macrophages ◽  
Inflammasome Activation ◽  
Intracellular Pathogens ◽  
Mhc Ii ◽  
Autophagy Induction ◽  
Pathogen Clearance ◽  
Deficient Mice ◽  
Specific Deletion

The p38 regulated/activated protein kinase (PRAK) is a protein kinase downstream of p38MAPK. The present study investigated its function in the macrophage. Myeloid-specific deletion of Prak resulted in a significant reduction in F4/80+CD11b+ peritoneal macrophages with decreased expression of MHC-II and CD80. Upon infection with Listeria monocytogenes, Prak-deficient mice demonstrated an increased mortality, which was accompanied by a higher bacterial load in multiple tissues and elevated levels of proinflammatory cytokines in the serum. While the Prak-deficient macrophage showed similar potency in phagocytosis assays, its bactericidal activity was severely impaired. Moreover, Prak deficiency was associated with defects in ROS production, inflammasome activation as well as autophagy induction. Therefore, PRAK critically contributes to the clearance of intracellular pathogens by affecting multiple aspects of the macrophage function.

scholarly journals ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

2016 ◽  
Vol 7 ◽  
Author(s):  
Qing-Bing Zha ◽  
Hong-Xia Wei ◽  
Chen-Guang Li ◽  
Yi-Dan Liang ◽  
Li-Hui Xu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Inflammasome Activation ◽  
Amp Activated Protein Kinase

scholarly journals Abortive HIV‐1 RNA induces pro‐IL‐1β maturation via protein kinase PKR and inflammasome activation in humans

2021 ◽  
Author(s):  
Melissa Stunnenberg ◽  
John L. Hamme ◽  
Marjolein Trimp ◽  
Sonja I. Gringhuis ◽  
Teunis B.H. Geijtenbeek
Keyword(s):  
Protein Kinase ◽  
Inflammasome Activation ◽  
Hiv 1
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