scholarly journals Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity

2013 ◽  
Vol 43 (7) ◽  
pp. 1779-1788 ◽  
Author(s):  
Tobias Gustafsson ◽  
Yeu-Jiann Hua ◽  
Madelene W. Dahlgren ◽  
Megan Livingston ◽  
Bengt Johansson-Lindbom ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cholera Toxin ◽  
Direct Interaction ◽  
Adjuvant Activity

scholarly journals The Potent Adjuvant Activity of Archaeosomes Correlates to the Recruitment and Activation of Macrophages and Dendritic Cells In Vivo

2001 ◽  
Vol 166 (3) ◽  
pp. 1885-1893 ◽  
Author(s):  
Lakshmi Krishnan ◽  
Subash Sad ◽  
Girishchandra B. Patel ◽  
G. Dennis Sprott
Keyword(s):  
Dendritic Cells ◽  
Adjuvant Activity

scholarly journals CpG ODN Nanorings Induce IFN  from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

2014 ◽  
Vol 6 (235) ◽  
pp. 235ra61-235ra61 ◽  
Author(s):  
B. Gungor ◽  
F. C. Yagci ◽  
G. Tincer ◽  
B. Bayyurt ◽  
E. Alpdundar ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Vaccine Adjuvant ◽  
Cpg Odn ◽  
Adjuvant Activity

scholarly journals Splenic Marginal Zone Dendritic Cells Mediate the Cholera Toxin Adjuvant Effect: Dependence on the ADP-Ribosyltransferase Activity of the Holotoxin

2005 ◽  
Vol 175 (8) ◽  
pp. 5192-5202 ◽  
Author(s):  
Dubravka Grdic ◽  
Lena Ekman ◽  
Karin Schön ◽  
Kristina Lindgren ◽  
Johan Mattsson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cholera Toxin ◽  
Marginal Zone ◽  
Adjuvant Effect ◽  
Adp Ribosyltransferase

scholarly journals Pasteurella multocida Toxin Activates Human Monocyte-Derived and Murine Bone Marrow-Derived Dendritic Cells In Vitro but Suppresses Antibody Production In Vivo

2005 ◽  
Vol 73 (1) ◽  
pp. 413-421 ◽  
Author(s):  
Kenneth C. Bagley ◽  
Sayed F. Abdelwahab ◽  
Robert G. Tuskan ◽  
George K. Lewis
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Phospholipase C ◽  
Cholera Toxin ◽  
Pasteurella Multocida ◽  
Human Monocyte ◽  
Mouse Bone Marrow ◽  
Dependent Manner

ABSTRACT Pasteurella multocida toxin (PMT) is a potent mitogen for fibroblasts and osteoblastic cells. PMT activates phospholipase C-β through Gqα, and the activation of this pathway is responsible for its mitogenic activity. Here, we investigated the effects of PMT on human monocyte-derived dendritic cells (MDDC) in vitro and show a novel activity for PMT. In this regard, PMT activates MDDC to mature in a dose-dependent manner through the activation of phospholipase C and subsequent mobilization of calcium. This activation was accompanied by enhanced stimulation of naïve alloreactive T cells and dominant inhibition of interleukin-12 production in the presence of saturating concentrations of lipopolysaccharide. Surprisingly, although PMT mimics the activating effects of cholera toxin on human MDDC and mouse bone marrow-derived dendritic cells, we found that PMT is not a mucosal adjuvant and that it suppresses the adjuvant effects of cholera toxin in mice. Together, these results indicate discordant effects for PMT in vitro compared to those in vivo.

Regional, but not systemic recruitment/expansion of dendritic cells by a pluronic-formulated Flt3-ligand plasmid with vaccine adjuvant activity

Vaccine ◽  
2003 ◽  
Vol 21 (21-22) ◽  
pp. 3019-3029 ◽  
Author(s):  
Hongxun Sang ◽  
Vladimir M. Pisarev ◽  
Corey Munger ◽  
Simon Robinson ◽  
Jennifer Chavez ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Vaccine Adjuvant ◽  
Flt3 Ligand ◽  
Adjuvant Activity

scholarly journals The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59822 ◽  
Author(s):  
Anouk K. Gloudemans ◽  
Maud Plantinga ◽  
Martin Guilliams ◽  
Monique A. Willart ◽  
Arifa Ozir-Fazalalikhan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Retinoic Acid ◽  
Cholera Toxin ◽  
Toxin B ◽  
Mucosal Adjuvant ◽  
Cholera Toxin B ◽  
Iga Production

scholarly journals Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity

2008 ◽  
Vol 84 (1) ◽  
pp. 199-206 ◽  
Author(s):  
Barbara Valentinis ◽  
Annalisa Capobianco ◽  
Francesca Esposito ◽  
Alessandro Bianchi ◽  
Patrizia Rovere-Querini ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Adjuvant Activity

scholarly journals Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenzhong Zheng ◽  
Shiqiang Zhang ◽  
Xiaobao Chen ◽  
Shaoqin Jiang ◽  
Zhihao Li ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Case Report ◽  
Chronic Inflammation ◽  
Genital Tract ◽  
Direct Interaction ◽  
Inflammatory Cells ◽  
First Case ◽  
Antigen Presenting ◽  
Possible Cause ◽  
Hematoxylin Eosin

Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Chronic epididymitis appears to be more important than seminal vesiculitis or prostatitis due to the direct interaction between spermatozoa and epididymal inflammatory cells. In this study, we present a case report of a 41-year-old male with oligoasthenospermia and chronic epididymitis. Hematoxylin-eosin staining and immunofluorescence analyses showed that antigen presenting cells including macrophages and dendritic cells were found capturing spermatozoa in the lumen of cauda epididymis. To our knowledge, this is the first case report that directly observed dendritic cells capturing spermatozoa in the lumen of an inflamed epididymis. This finding directly explains chronic epididymitis as the possible cause of oligospermia in patients.

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