scholarly journals The immature B-cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse

2009 ◽  
Vol 39 (2) ◽  
pp. 600-611 ◽  
Author(s):  
Teppei Toda ◽  
Masahiro Kitabatake ◽  
Hideya Igarashi ◽  
Nobuo Sakaguchi
Keyword(s):  
New Zealand ◽  
B Cell ◽  
Cell Subpopulation ◽  
Black Mouse ◽  
New Zealand Black Mouse

scholarly journals The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia

2010 ◽  
Vol 78B (S1) ◽  
pp. S98-S109 ◽  
Author(s):  
Erica Salerno ◽  
Yao Yuan ◽  
Brian J. Scaglione ◽  
Gerald Marti ◽  
Alexander Jankovic ◽  
...  
Keyword(s):  
New Zealand ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Black Mouse ◽  
New Zealand Black Mouse

Two distinct monoclonal natural thymocytotoxic autoantibodies from New Zealand black mouse

1989 ◽  
Vol 53 (3) ◽  
pp. 475-487 ◽  
Author(s):  
Makoto Ohgaki ◽  
Genjiroh Ueda ◽  
Jun Shiota ◽  
Hiroyuki Nishimura ◽  
Sachiko Hirose ◽  
...  
Keyword(s):  
New Zealand ◽  
Black Mouse ◽  
New Zealand Black Mouse

A monoclonal thymocytotoxic autoantibody from autoimmune-disease-prone New Zealand Black mouse recognizes β-tubulin in neural tissue

1993 ◽  
Vol 16 (4) ◽  
pp. 293-299 ◽  
Author(s):  
Mie Kamiya ◽  
Momoko Miyakawa ◽  
Genjiroh Ueda ◽  
Toshikazu Shirai ◽  
Yasumasa Arai
Keyword(s):  
New Zealand ◽  
Autoimmune Disease ◽  
Neural Tissue ◽  
Black Mouse ◽  
New Zealand Black Mouse ◽  
Β Tubulin

scholarly journals Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model

2007 ◽  
Vol 139 (5) ◽  
pp. 645-657 ◽  
Author(s):  
Brian J. Scaglione ◽  
Erica Salerno ◽  
Murugabaskar Balan ◽  
Frederick Coffman ◽  
Pablo Landgraf ◽  
...  
Keyword(s):  
New Zealand ◽  
Mouse Model ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Murine Models ◽  
Black Mouse ◽  
New Zealand Black Mouse

Complexity of the immunoglobulin light chain Vκ1 gene family in the New Zealand Black mouse

1991 ◽  
Vol 3 (8) ◽  
pp. 751-760 ◽  
Author(s):  
N. C. Bailey ◽  
K. N. Kasturi ◽  
T. K. Blackwell ◽  
F. W. Alt ◽  
C. A. Bona ◽  
...  
Keyword(s):  
New Zealand ◽  
Gene Family ◽  
Light Chain ◽  
Immunoglobulin Light Chain ◽  
Black Mouse ◽  
New Zealand Black Mouse

scholarly journals Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity

2009 ◽  
Vol 8 (9) ◽  
pp. 2684-2692 ◽  
Author(s):  
Erica Salerno ◽  
Brian J. Scaglione ◽  
Frederick D. Coffman ◽  
Brian D. Brown ◽  
Alessia Baccarini ◽  
...  
Keyword(s):  
New Zealand ◽  
Mouse Model ◽  
Drug Sensitivity ◽  
Genetic Defect ◽  
Black Mouse ◽  
New Zealand Black Mouse

Effect of ultraviolet light irradiation on the survival of new zealand black mouse cells

1980 ◽  
Vol 23 (7) ◽  
pp. 866-867 ◽  
Author(s):  
Glen B. Zamansky ◽  
Lawrence F. Kleinman ◽  
Joan C. Kaplan ◽  
Paul H. Black
Keyword(s):  
New Zealand ◽  
Ultraviolet Light ◽  
Light Irradiation ◽  
Black Mouse ◽  
Ultraviolet Light Irradiation ◽  
Mouse Cells ◽  
New Zealand Black Mouse

Behavioral impairments related to cognitive dysfunction in the autoimmune New Zealand black mouse.

1986 ◽  
Vol 100 (3) ◽  
pp. 353-358 ◽  
Author(s):  
David G. Spencer ◽  
Kathleen Humphries ◽  
Diane Mathis ◽  
Harbans Lal
Keyword(s):  
New Zealand ◽  
Cognitive Dysfunction ◽  
Black Mouse ◽  
Behavioral Impairments ◽  
New Zealand Black Mouse

scholarly journals Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

2004 ◽  
Vol 200 (4) ◽  
pp. 519-525 ◽  
Author(s):  
Bradley T. Messmer ◽  
Emilia Albesiano ◽  
Dimitar G. Efremov ◽  
Fabio Ghiotto ◽  
Steven L. Allen ◽  
...  
Keyword(s):  
Amino Acid ◽  
B Cell ◽  
Structural Features ◽  
Lymphocytic Leukemia ◽  
Cell Subpopulation ◽  
Amino Acid Residues ◽  
Antigen Receptors ◽  
Region Gene ◽  
V Region ◽  
Unique Amino Acid

Previous studies suggest that the diversity of the expressed variable (V) region repertoire of the immunoglobulin (Ig)H chain of B-CLL cells is restricted. Although limited examples of marked constraint in the primary structure of the H and L chain V regions exist, the possibility that this level of restriction is a general principle in this disease has not been accepted. This report describes five sets of patients, mostly with unmutated or minimally mutated IgV genes, with strikingly similar B cell antigen receptors (BCRs) arising from the use of common H and L chain V region gene segments that share CDR3 structural features such as length, amino acid composition, and unique amino acid residues at recombination junctions. Thus, a much more striking degree of structural restriction of the entire BCR and a much higher frequency of receptor sharing exists among patients than appreciated previously. The data imply that either a significant fraction of B-CLL cells was selected by a limited set of antigenic epitopes at some point in their development and/or that they derive from a distinct B cell subpopulation with limited Ig V region diversity. These shared, stereotyped Ig molecules may be valuable probes for antigen identification and important targets for cross-reactive idiotypic therapy.

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