scholarly journals Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways

2008 ◽  
Vol 38 (4) ◽  
pp. 1058-1064 ◽  
Author(s):  
Marc Ittah ◽  
Corinne Miceli-Richard ◽  
Jacques-Eric Gottenberg ◽  
Jérémie Sellam ◽  
Pierre Eid ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
High Expression ◽  
Type I ◽  
Type I Ifn ◽  
Salivary Gland Epithelial Cells

scholarly journals Direct Infection of Primary Salivary Gland Epithelial Cells by Human T Lymphotropic Virus Type I in Patients With Sjögren's Syndrome

2015 ◽  
Vol 67 (4) ◽  
pp. 1096-1106 ◽  
Author(s):  
Hideki Nakamura ◽  
Yoshiko Takahashi ◽  
Tomomi Yamamoto-Fukuda ◽  
Yoshiro Horai ◽  
Yoshikazu Nakashima ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Virus Type ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Type I ◽  
T Lymphotropic Virus ◽  
Salivary Gland Epithelial Cells ◽  
Sjögren‘S Syndrome

scholarly journals Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 845
Author(s):  
Maria Ciccolella ◽  
Sara Andreone ◽  
Jacopo Mancini ◽  
Paola Sestili ◽  
Donatella Negri ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Biological Effects ◽  
Salivary Gland Tumors ◽  
Sublingual Administration ◽  
Type I ◽  
Type I Ifn ◽  
Tumor Models ◽  
Antitumor Effects ◽  
Duct Carcinoma ◽  
Administration Routes

Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for SDC due to the induction of both local and systemic biological effects and to reduced systemic toxicity compared to other administration routes. In the present study, we first established that the sublingual administration of type I IFN (IFN-I) is safe and feasible, and exerts antitumor effects both as monotherapy and in combination with chemotherapy in transplantable tumor models, i.e., B16-OVA melanoma and EG.7-OVA lymphoma. Subsequently, we proved that sublingual IFN-I in combination with cyclophosphamide (CTX) induces a long-lasting reduction of tumor mass in NeuT transgenic mice that spontaneously develop SDC. Most importantly, tumor shrinkage in NeuT transgenic micewas accompanied by the emergence of tumor-specific cellular immune responses both in the blood and in the tumor tissue. Altogether, these results provide evidence that sublingual IFN holds promise in combination with chemotherapy for the treatment of cancer.

scholarly journals Salivary gland epithelial cells: A new source of the immunoregulatory hormone adiponectin

2006 ◽  
Vol 54 (7) ◽  
pp. 2295-2299 ◽  
Author(s):  
Stergios Katsiougiannis ◽  
Efstathia K. Kapsogeorgou ◽  
Menelaos N. Manoussakis ◽  
Fotini N. Skopouli
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Salivary Gland Epithelial Cells

scholarly journals TLR3-mediated induction of Ro/SSA and La/SSB mRNA expression in salivary gland epithelial cells

2012 ◽  
Vol 71 (Suppl 1) ◽  
pp. A87.1-A87
Author(s):  
Nikolaos C Kyriakidis ◽  
Efstathia K Kapsogeorgou ◽  
Vasiliki C Gourzi ◽  
Menelaos N Manoussakis ◽  
Haralampos M Moutsopoulos ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Mrna Expression ◽  
Salivary Gland Epithelial Cells

scholarly journals Expression of Podoplanin and Classical Cadherins in Salivary Gland Epithelial Cells of Klotho-Deficient Mice

2011 ◽  
Vol 44 (6) ◽  
pp. 267-276 ◽  
Author(s):  
Ikuko Amano ◽  
Yuri Imaizumi ◽  
Chiaki Kaji ◽  
Hiroshi Kojima ◽  
Yoshihiko Sawa
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Classical Cadherins ◽  
Salivary Gland Epithelial Cells ◽  
Deficient Mice

scholarly journals Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sj�gren's syndrome

1999 ◽  
Vol 42 (2) ◽  
pp. 229-239 ◽  
Author(s):  
Menelaos N. Manoussakis ◽  
Ioannis D. Dimitriou ◽  
Efstathia K. Kapsogeorgou ◽  
Georgia Xanthou ◽  
Spiros Paikos ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Costimulatory Molecules ◽  
Salivary Gland Epithelial Cells
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