scholarly journals Anti-chromatin antibodies drivein vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites

2007 ◽  
Vol 37 (12) ◽  
pp. 3339-3351 ◽  
Author(s):  
Robin A. Herlands ◽  
Jacqueline William ◽  
Uri Hershberg ◽  
Mark J. Shlomchik
Keyword(s):  
B Cells ◽  
Rheumatoid Factor ◽  
Somatic Hypermutation ◽  
Factor B

Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells

2004 ◽  
Vol 10 (4) ◽  
pp. 247-251 ◽  
Author(s):  
Ann Marshak-Rothstein ◽  
Liliana Busconi ◽  
Christina M. Lau ◽  
Abigail S. Tabor ◽  
Elizabeth A. Leadbetter ◽  
...  
Keyword(s):  
B Cells ◽  
Rheumatoid Factor ◽  
Immune Complexes ◽  
Factor B

scholarly journals Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG

1997 ◽  
Vol 94 (2) ◽  
pp. 646-651 ◽  
Author(s):  
H. Tighe ◽  
K. Warnatz ◽  
D. Brinson ◽  
M. Corr ◽  
W. O. Weigle ◽  
...  
Keyword(s):  
B Cells ◽  
Rheumatoid Factor ◽  
Factor B

scholarly journals Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus

2015 ◽  
Vol 98 (2) ◽  
pp. 209-221
Author(s):  
Allison Sang ◽  
Ying Yi Zheng ◽  
Seung-Chul Choi ◽  
Leilani Zeumer ◽  
Laurence Morel
Keyword(s):  
B Cells ◽  
Mouse Model ◽  
Rheumatoid Factor ◽  
Factor B

A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells

2002 ◽  
Vol 32 (9) ◽  
pp. 2623-2634 ◽  
Author(s):  
Pauline Soulas ◽  
Severine Koenig-Marrony ◽  
Sylvie Julien ◽  
Anne-Marie Knapp ◽  
Jean-Claude Garaud ◽  
...  
Keyword(s):  
B Cells ◽  
Rheumatoid Factor ◽  
Factor B

scholarly journals Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells.

1991 ◽  
Vol 173 (2) ◽  
pp. 487-489 ◽  
Author(s):  
E Roosnek ◽  
A Lanzavecchia
Keyword(s):  
T Cells ◽  
B Cells ◽  
Rheumatoid Factor ◽  
Factor B ◽  
Barr Virus ◽  
Membrane Immunoglobulin ◽  
Cell Clones ◽  
Lower Extent ◽  
Epstein Barr ◽  
Antigen Antibody

Using Epstein-Barr virus B cell clones and antigen-specific T cell clones, we asked how antigen-antibody complexes are handled by B cells. We found that the only B cells capable of efficient presentation of antigen-antibody complexes are those that bind the complexes via membrane immunoglobulin, i.e., rheumatoid factor-producing B cells and, to a lower extent, antigen-specific B cells. On the contrary, nonspecific B cells, although capable of binding antigen-antibody complexes, fail to present them to T cells. Thus, rheumatoid factor B cells can present any antigen in the context of an immune complex and be triggered by T cells specific for a variety of foreign antigens. These results demonstrate a mechanism of intermolecular help that may be responsible for the production of rheumatoid factor and possibly of other types of autoantibodies.

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