Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igκ-reactive macroself antigen

2006 ◽  
Vol 36 (4) ◽  
pp. 985-996 ◽  
Author(s):  
Djemel Aït-Azzouzene ◽  
Amanda L. Gavin ◽  
Patrick Skog ◽  
Bao Duong ◽  
David Nemazee
Keyword(s):  
Transgenic Mice ◽  
B Cell ◽  
Cell Survival ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
Low Level

scholarly journals Peripheral B Cell Tolerance and Function in Transgenic Mice Expressing an IgD Superantigen

2010 ◽  
Vol 184 (8) ◽  
pp. 4143-4158 ◽  
Author(s):  
Bao Hoa Duong ◽  
Takayuki Ota ◽  
Djemel Aït-Azzouzene ◽  
Miyo Aoki-Ota ◽  
José Luis Vela ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
B Cell ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
And Function

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

1991 ◽  
Vol 122 (1) ◽  
pp. 133-171 ◽  
Author(s):  
R. M. Zinkernagel ◽  
H. P. Pircher ◽  
P. Ohashi ◽  
S. Oehen ◽  
B. Odermatt ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
B Cell ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
Viral Antigens

scholarly journals Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.

1995 ◽  
Vol 181 (3) ◽  
pp. 1157-1167 ◽  
Author(s):  
J H Roark ◽  
C L Kuntz ◽  
K A Nguyen ◽  
A J Caton ◽  
J Erikson
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
Mouse Model ◽  
Transgenic Mice ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Tolerance ◽  
Systemic Lupus ◽  
B Cell Tolerance ◽  
Dna Antibodies

Anti-DNA antibodies, specifically those that stain nuclei in a homogenous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model. We have used a heavy chain transgene that increases the frequency of anti-HN antibodies to address whether their production in SLE is the consequence of a defect in B cell tolerance. Anti-HN B cells were undetectable in nonautoimmune-prone transgenic mice, but in MRL-lpr/lpr transgenic mice their Ig was evident in the sera and they were readily retrievable as hybridomas. We conclude that nonautoimmune animals actively delete anti-HN-specific B cells, and that MRL-lpr/lpr mice are defective in this process possibly because of the lpr defect in the fas gene.

Disruption of B cell tolerance in C4-l-anti-DNA transgenic mice

2000 ◽  
Vol 49 (1-2) ◽  
pp. 42
Author(s):  
E. Paul ◽  
L. Mandik-Nayak ◽  
J. Erikson ◽  
M.C. Carroll
Keyword(s):  
Transgenic Mice ◽  
B Cell ◽  
Cell Tolerance ◽  
B Cell Tolerance
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