scholarly journals The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system

2006 ◽  
Vol 36 (4) ◽  
pp. 906-918 ◽  
Author(s):  
Xuesong Qian ◽  
Kazunaga Agematsu ◽  
Gordon J. Freeman ◽  
Yoh-ichi Tagawa ◽  
Kazuo Sugane ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Host Defense ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Defense System ◽  
Alveolar Epithelial ◽  
Human Type ◽  
Host Defense System

scholarly journals Effect of ulinastatin on paraquat-induced-oxidative stress in human type II alveolar epithelial cells

2013 ◽  
Vol 4 (2) ◽  
pp. 133 ◽  
Author(s):  
Xiao-xiao Meng ◽  
Rui-lan Wang ◽  
Shan Gao ◽  
Hui Xie ◽  
Jiu-ting Tan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Alveolar Epithelial ◽  
Human Type

scholarly journals Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Véronique Corbière ◽  
Violette Dirix ◽  
Sarah Norrenberg ◽  
Mattéo Cappello ◽  
Myriam Remmelink ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Epithelial Cells ◽  
Antigen Presentation ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Phenotypic Characteristics ◽  
Alveolar Epithelial ◽  
Human Type

Novel anti-oxidative role of calreticulin in protecting A549 human type II alveolar epithelial cells against hypoxic injury

2008 ◽  
Vol 294 (1) ◽  
pp. C47-C55 ◽  
Author(s):  
Lingyun Jia ◽  
Mingjiang Xu ◽  
Wei Zhen ◽  
Xun Shen ◽  
Yi Zhu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
A549 Cells ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Cell Protection ◽  
Short Term ◽  
Hypoxic Injury ◽  
Alveolar Epithelial ◽  
Human Type ◽  
Ros Accumulation

Short-term hypoxic pretreatment is an effective approach to protect the lung from subsequent prolonged hypoxic injury under conditions such as lung transplantation, shock, and trauma. However, the signaling pathways are not well understood. By use of high-throughput, two-dimensional electrophoresis combined with mass spectrometry, we found that short-term hypoxic treatment upregulated calreticulin (CRT), an endoplasmic-reticulum stress protein, in A549 human type II alveolar epithelial cells. Genetic manipulation of CRT expression in A549 cells through small interferring RNA inhibition or overexpression demonstrated a positive correlation between CRT expression level and cell viability in subsequent prolonged hypoxia, which indicates that CRT is a key mediator of short-term hypoxia-induced cell protection. Importantly, CRT overexpression prevented reactive oxygen species (ROS) accumulation during prolonged hypoxia by inducing the expression of thioredoxin (TRX), an antioxidant, in A549 cells. Furthermore, CRT promoted the nuclear translocation of nuclear factor-E2-related factor 2, the transcription factor of TRX. Finally, overexpressing an inactive TRX mutant reversed the effects of CRT on ROS accumulation and cell protection. Our results demonstrate that CRT stimulates the anti-oxidant pathway and contributes to short-term hypoxia-induced protection in A549 type II alveolar epithelial cells, which may have potential therapeutic ramifications for hypoxic pulmonary diseases.

Preservation of the Characteristics of the Cultured Human Type II Alveolar Epithelial Cells

Lung ◽  
2004 ◽  
Vol 182 (4) ◽  
pp. 213-226 ◽  
Author(s):  
Kimiko Takahashi ◽  
Masako Mitsui ◽  
Kyoko Takeuchi ◽  
Yasuhide Uwabe ◽  
Katsuyuki Kobayashi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Alveolar Epithelial ◽  
Human Type
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