scholarly journals Switching from a restricted to an effective CD4 T cell response by activating CD8+ murine dendritic cells with a Toll-like receptor 9 ligand

2005 ◽  
Vol 35 (11) ◽  
pp. 3209-3220 ◽  
Author(s):  
Alexandra Rizzitelli ◽  
David Vremec ◽  
Jose A. Villadangos ◽  
Nasim Mavaddat ◽  
Mark D. Wright ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Toll Like Receptor

CD8alpha+ dendritic cells enhance the antigen-specific CD4+ T-cell response and accelerate development of collagen-induced arthritis

2007 ◽  
Vol 111 (2) ◽  
pp. 76-83 ◽  
Author(s):  
Young Ok Jung ◽  
So-Youn Min ◽  
Mi-La Cho ◽  
Min-Jung Park ◽  
Ju-Youn Jeon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Collagen Induced Arthritis ◽  
Accelerate Development

Lentiviral gp34/OX40L Gene Transfer into Dendritic Cells Facilitates Alloreactive CD4 + T-Cell Response In Vitro

2004 ◽  
Vol 79 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Masayuki Kobayashi ◽  
Akifumi Takaori-Kondo ◽  
Keiko Fukunaga ◽  
Hiroyuki Miyoshi ◽  
Takashi Uchiyama
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Gene Transfer ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell

scholarly journals Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4+ T Cell Response

Immunity ◽  
2006 ◽  
Vol 25 (4) ◽  
pp. 655-664 ◽  
Author(s):  
Felix Yarovinsky ◽  
Holger Kanzler ◽  
Sara Hieny ◽  
Robert L. Coffman ◽  
Alan Sher
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Toll Like Receptor ◽  
Receptor Recognition

In situ targeting of dendritic cells sets tolerogenic environment and ameliorates CD4+ T cell response in the postischemic liver

2017 ◽  
Author(s):  
D Funken ◽  
H Ishikawa-Ankerhold ◽  
M Lerchenberger ◽  
D Mayr ◽  
M Rentsch ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell

scholarly journals FcγRIIIa-Syk Co-signal Modulates CD4+T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

2015 ◽  
Vol 291 (3) ◽  
pp. 1368-1386 ◽  
Author(s):  
Anil K. Chauhan ◽  
Terry L. Moore ◽  
Ye Bi ◽  
Chen Chen
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Toll Like Receptor

scholarly journals A polyclonal anti-vaccine CD4 T cell response detected with HLA-DP4 multimers in a melanoma patient vaccinated with MAGE-3.DP4-peptide-pulsed dendritic cells

2005 ◽  
Vol 35 (4) ◽  
pp. 1066-1075 ◽  
Author(s):  
Yi Zhang ◽  
Nicolina Renkvist ◽  
Zhaojun Sun ◽  
Beatrice Schuler-Thurner ◽  
Nicolas Glaichenhaus ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
Melanoma Patient ◽  
T Cell Response ◽  
Cd4 T Cell

scholarly journals Optimal CD8 T-Cell Response against Encephalitozoon cuniculi Is Mediated by Toll-Like Receptor 4 Upregulation by Dendritic Cells

2010 ◽  
Vol 78 (7) ◽  
pp. 3097-3102 ◽  
Author(s):  
Elizabeth M. Lawlor ◽  
Magali M. Moretto ◽  
Imtiaz A. Khan
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Cell Response ◽  
T Cell Response ◽  
T Cell Immunity ◽  
Toll Like Receptor ◽  
Encephalitozoon Cuniculi ◽  
Toll Like Receptor 4 ◽  
Cell Immunity

ABSTRACT CD8+ T-cell immunity has been shown to play an important role in the protective immune response against Encephalitozoon cuniculi. Although earlier studies suggest that dendritic cells (DC) are important for the induction of this response, the factors responsible for initiation of the dendritic cell response against this pathogen have not been evaluated. In the current study, we demonstrate that E. cuniculi infection causes strong Toll-like receptor 4 (TLR4)-dependent dendritic cell activation and a blockade of this molecule reduces the ability of DC to prime an antigen-specific CD8+ T-cell response. Pretreatment of DC with anti-TLR4 antibody causes a defect in both in vitro and in vivo CD8+ T-cell priming. These findings, for the first time, emphasize the contribution of TLR4 in the induction of CD8+ T-cell immunity against E. cuniculi infection.

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