A genetic contamination in MHC-congenic mouse strains reveals a locus on chromosome 10 that determines autoimmunity and arthritis susceptibility

2005 ◽  
Vol 35 (4) ◽  
pp. 1275-1282 ◽  
Author(s):  
Kutty?Selva Nandakumar ◽  
Rikard Holmdahl
Keyword(s):  
Congenic Mouse ◽  
Mouse Strains ◽  
Chromosome 10 ◽  
Genetic Contamination ◽  
Congenic Mouse Strains ◽  
Arthritis Susceptibility

scholarly journals Erbb is linked to the alpha-globin locus on mouse chromosome 11.

1985 ◽  
Vol 5 (7) ◽  
pp. 1784-1786 ◽  
Author(s):  
J Silver ◽  
J B Whitney ◽  
C Kozak ◽  
G Hollis ◽  
I Kirsch
Keyword(s):  
Mouse Chromosome ◽  
Human Gene ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Somatic Cell Hybrids ◽  
Chromosome 11 ◽  
Homologous Sequences ◽  
Alpha Globin ◽  
Mouse Chromosome 11 ◽  
Congenic Mouse Strains

A fragment of the human gene for c-erb-B was used to map homologous sequences in mice. Analysis of somatic cell hybrids and recombinant inbred and congenic mouse strains indicated that this gene, designated Erbb, is closely linked to the gene for alpha-globin on mouse chromosome 11. Several genes controlling hematopoietic differentiation map to mouse chromosome 11.

Mating preferences of F2 segregants of crosses between MHC-congenic mouse strains

1978 ◽  
Vol 6 (1) ◽  
pp. 253-259 ◽  
Author(s):  
K. Yamazaki ◽  
M. Yamaguchi ◽  
P. W. Andrews ◽  
B. Peake ◽  
E. A. Boyse
Keyword(s):  
Congenic Mouse ◽  
Mouse Strains ◽  
Mating Preferences ◽  
Congenic Mouse Strains

Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci

1999 ◽  
Vol 49 (3) ◽  
pp. 238-241 ◽  
Author(s):  
A. A. Scalzo ◽  
Michael G. Brown ◽  
Dortha T. Chu ◽  
Jonathan W. Heusel ◽  
Wayne M. Yokoyama ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Natural Killer ◽  
Nk Cell ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Regulatory Loci ◽  
Congenic Mouse Strains

scholarly journals Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine nociceptive assays

Pain ◽  
2006 ◽  
Vol 126 (1) ◽  
pp. 24-34 ◽  
Author(s):  
Jeffrey S. Mogil ◽  
Jennifer Ritchie ◽  
Susana G. Sotocinal ◽  
Shad B. Smith ◽  
Sylvie Croteau ◽  
...  
Keyword(s):  
Congenic Mouse ◽  
Mouse Strains ◽  
Congenic Mouse Strains

scholarly journals The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2.

1984 ◽  
Vol 159 (3) ◽  
pp. 958-963 ◽  
Author(s):  
P D'Eustachio ◽  
B Fein ◽  
J Michaelson ◽  
B A Taylor
Keyword(s):  
Dna Sequences ◽  
Inbred Strains ◽  
Congenic Mouse ◽  
Chromosome 17 ◽  
Mouse Strains ◽  
Globin Genes ◽  
Somatic Cell Hybrids ◽  
Chromosome 11 ◽  
Alpha Globin ◽  
Congenic Mouse Strains

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2.

scholarly journals Genetic Mapping of Vocalization to a Series of Increasing Acute Footshocks Using B6.A Consomic and B6.D2 Congenic Mouse Strains

2008 ◽  
Vol 38 (4) ◽  
pp. 417-423 ◽  
Author(s):  
Douglas B. Matthews ◽  
Elissa J. Chesler ◽  
Melloni N. Cook ◽  
Jody Cockroft ◽  
Vivek M. Philip ◽  
...  
Keyword(s):  
Genetic Mapping ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Congenic Mouse Strains

scholarly journals Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.

1992 ◽  
Vol 176 (5) ◽  
pp. 1483-1487 ◽  
Author(s):  
D J Rawlings ◽  
D C Kaslow
Keyword(s):  
Immune Response ◽  
Recombinant Protein ◽  
Antibody Response ◽  
Vaccine Candidate ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Transmission Blocking ◽  
Freund's Adjuvant ◽  
Congenic Mouse Strains ◽  
Transmission Blocking Vaccine

Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all five congenic mouse strains responded to several transmission-blocking vaccine candidate antigens, when parasites were emulsified in a monophosphoryl lipid A (MPL) and trehalose dimycolate (TDM) adjuvant. The humoral response in those animals immunized with the antigen in a MPL/TDM adjuvant was helper T cell dependent, as evident by boosting of the antibody response after a second immunization. If the immunogen consisted of purified recombinant protein, then the immune response was not MHC class II limited in mice immunized with either complete Freund's adjuvant or TDM/MPL. The potential role of adjuvants in overcoming apparent immune nonresponsiveness and the implications for development of a malaria transmission-blocking vaccine are discussed.

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