scholarly journals The MHC class?II transactivator (CIITA) mRNA stability is critical for the HLA class?II gene expression in myelomonocytic cells

2005 ◽  
Vol 35 (2) ◽  
pp. 603-611 ◽  
Author(s):  
Andrea De Lerma Barbaro ◽  
Francesco?A. Procopio ◽  
Lorenzo Mortara ◽  
Giovanna Tosi ◽  
Roberto?S. Accolla
Keyword(s):  
Gene Expression ◽  
Mhc Class Ii ◽  
Mrna Stability ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class Ii Transactivator ◽  
Myelomonocytic Cells ◽  
Mhc Class Ii Transactivator

scholarly journals The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins

2021 ◽  
Vol 22 (3) ◽  
pp. 1074
Author(s):  
Jorge Alfonso León Machado ◽  
Viktor Steimle
Keyword(s):  
Gene Expression ◽  
Mhc Class Ii ◽  
Protein Interactions ◽  
Transcriptional Regulator ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc I ◽  
Mhc Ii ◽  
Mhc Class Ii Transactivator

In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat (NLR) protein family but stood apart for a long time as the only transcriptional regulator. More recently, it was found that its closest homolog, NLRC5 (NLR protein caspase activation and recruitment domain (CARD)-containing 5), is a regulator of MHC-I gene expression. Both act as non-DNA-binding activators through multiple protein–protein interactions with an MHC enhanceosome complex that binds cooperatively to a highly conserved combinatorial cis-acting module. Thus, the regulation of MHC-II expression is regulated largely through the differential expression of CIITA. In addition to the well-defined role of CIITA in MHC-II GENE regulation, we will discuss several other aspects of CIITA functions, such as its role in cancer, its role as a viral restriction element contributing to intrinsic immunity, and lastly, its very recently discovered role as an inhibitor of Ebola and SARS-Cov-2 virus replication. We will briefly touch upon the recently discovered role of NLRP3 as a transcriptional regulator, which suggests that transcriptional regulation is, after all, not such an unusual feature for NLR proteins.

scholarly journals The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1

Retrovirology ◽  
2015 ◽  
Vol 12 (S1) ◽  
Author(s):  
Greta Forlani ◽  
Rawan Abdallah ◽  
Luisa Guidali ◽  
Roberto S Accolla ◽  
Giovanna Tosi
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo

2017 ◽  
Vol 47 (8) ◽  
pp. 1317-1323 ◽  
Author(s):  
David A. Anderson ◽  
Gary E. Grajales-Reyes ◽  
Ansuman T. Satpathy ◽  
Carlos E. Vasquez Hueichucura ◽  
Theresa L. Murphy ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148753 ◽  
Author(s):  
Yves B. Beaulieu ◽  
Jorge A. Leon Machado ◽  
Sylvain Ethier ◽  
Luc Gaudreau ◽  
Viktor Steimle
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
N Terminus ◽  
Promoter Recruitment ◽  
Mhc Class Ii Transactivator
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