scholarly journals Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs

2004 ◽  
Vol 34 (11) ◽  
pp. 3126-3134 ◽  
Author(s):  
Xincheng Zheng ◽  
Lijie Yin ◽  
Yang Liu ◽  
Pan Zheng
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Hematopoietic Cells ◽  
Lymphoid Organs ◽  
Autoreactive T Cells ◽  
Tissue Specific ◽  
Activation Induced Cell Death ◽  
Secondary Lymphoid Organs

Quantitation and visualization of tumor-specific T cells in the secondary lymphoid organs during and after tumor elimination by PET

2004 ◽  
Vol 31 (8) ◽  
pp. 1021-1031 ◽  
Author(s):  
Ken Matsui ◽  
Zheng Wang ◽  
Timothy J. McCarthy ◽  
Paul M. Allen ◽  
David E. Reichert
Keyword(s):  
T Cells ◽  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

scholarly journals IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

2012 ◽  
Vol 72 (14) ◽  
pp. 3570-3581 ◽  
Author(s):  
Jan Emmerich ◽  
John B. Mumm ◽  
Ivan H. Chan ◽  
Drake LaFace ◽  
Hoa Truong ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
De Novo ◽  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

scholarly journals Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 ◽  
Vol 181 (1) ◽  
pp. 71-77 ◽  
Author(s):  
M R Alderson ◽  
T W Tough ◽  
T Davis-Smith ◽  
S Braddy ◽  
B Falk ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
T Cell ◽  
Fas Ligand ◽  
Significant Proportion ◽  
Cell Receptor ◽  
Target Cells ◽  
Activated T Cells ◽  
Activation Induced Cell Death ◽  
Fas L

A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways of apoptosis are causally related. Stimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions.

scholarly journals IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells

2006 ◽  
Vol 18 (6) ◽  
pp. 827-835 ◽  
Author(s):  
Catherine Riou ◽  
Alain R Dumont ◽  
Bader Yassine-Diab ◽  
Elias K Haddad ◽  
Rafick-Pierre Sekaly
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Cd8 T Cells ◽  
Activation Induced Cell Death

scholarly journals Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection

2020 ◽  
Vol 124 ◽  
pp. 218-228
Author(s):  
Rakesh H. Basavalingappa ◽  
Rajkumar Arumugam ◽  
Ninaad Lasrado ◽  
Bharathi Yalaka ◽  
Chandirasegaran Massilamany ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Viral Myocarditis ◽  
Lymphoid Organs ◽  
Autoreactive T Cells ◽  
Multiple Antigen ◽  
Cvb3 Infection
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