scholarly journals Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors

2004 ◽  
Vol 34 (4) ◽  
pp. 961-971 ◽  
Author(s):  
Pascale André ◽  
Roberta Castriconi ◽  
Marion Espéli ◽  
Nicolas Anfossi ◽  
Tiffany Juarez ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Cell Activation ◽  
Nk Cell ◽  
Natural Cytotoxicity ◽  
Natural Cytotoxicity Receptors

scholarly journals Involvement of Activating NK Cell Receptors and Their Modulation in Pathogen Immunity

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Francesco Marras ◽  
Federica Bozzano ◽  
Andrea De Maria
Keyword(s):  
Cell Activation ◽  
Nk Cell ◽  
Cell Structure ◽  
Natural Cytotoxicity ◽  
Cell Receptors ◽  
Nk Cell Receptors ◽  
Activating Receptors ◽  
Infected Cells ◽  
Killer Inhibitory Receptors ◽  
Natural Cytotoxicity Receptors

Natural Killer (NK) cells are endowed with cell-structure-sensing receptors providing inhibitory protection from self-destruction (inhibitory NK receptors, iNKRs, including killer inhibitory receptors and other molecules) and rapid triggering potential leading to functional cell activation by Toll-like receptors (TLRs), cytokine receptors, and activating NK cell receptors including natural cytotoxicity receptors (NCRs, i.e., NKp46, NKp46, and NKp44). NCR and NKG2D recognize ligands on infected cells which may be endogenous or may directly bind to some structures derived from invading pathogens. In this paper, we address the known direct or indirect interactions between activating receptors and pathogens and their expression during chronic HIV and HCV infections.

scholarly journals Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 156
Author(s):  
Jasmina M. Luczo ◽  
Sydney L. Ronzulli ◽  
Stephen M. Tompkins
Keyword(s):  
Influenza Virus ◽  
Nk Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Nk Cell ◽  
Influenza Virus Infection ◽  
Target Cells ◽  
Natural Cytotoxicity ◽  
Activating Receptors ◽  
Natural Cytotoxicity Receptors

Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors can lead to functional activation of NK cells, resulting in lysis of target cells. NK cell activating receptors specific for non-major histocompatibility complex ligands are NKp46, NKp44, NKp30, NKG2D, and CD16 (also known as FcγRIII). The natural cytotoxicity receptors (NCRs), NKp46, NKp44, and NKp30, have been implicated in functional activation of NK cells following influenza virus infection via binding with influenza virus hemagglutinin (HA). In this review we describe NK cell and influenza A virus biology, and the interactions of influenza A virus HA and other pathogen lectins with NK cell natural cytotoxicity receptors (NCRs). We review concepts which intersect viral immunology, traditional virology and glycobiology to provide insights into the interactions between influenza virus HA and the NCRs. Furthermore, we provide expert opinion on future directions that would provide insights into currently unanswered questions.

scholarly journals CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity

2003 ◽  
Vol 33 (12) ◽  
pp. 3367-3376 ◽  
Author(s):  
Emanuela Marcenaro ◽  
Raffaella Augugliaro ◽  
Michela Falco ◽  
Roberta Castriconi ◽  
Silvia Parolini ◽  
...  
Keyword(s):  
Nk Cell ◽  
Natural Cytotoxicity ◽  
Natural Cytotoxicity Receptors

scholarly journals Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

2021 ◽  
Vol 12 ◽  
Author(s):  
Christian Binder ◽  
Felix Sellberg ◽  
Filip Cvetkovski ◽  
Stefan Berg ◽  
Erik Berglund ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Nk Cells ◽  
Receptor Binding ◽  
Cell Activation ◽  
Mixed Lymphocyte Reaction ◽  
Nk Cell ◽  
Lymphocyte Culture ◽  
Natural Cytotoxicity ◽  
Allogeneic Mixed Lymphocyte Reaction ◽  
Autologous Lymphocyte

The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be expendable in antibody-mediated cytotoxicity. Siplizumab is a monoclonal anti-CD2 IgG1 antibody that is currently undergoing clinical trials in the field of transplantation. This study investigated the effect of CD2 binding and Fc γ receptor binding by siplizumab (Fc-active) and Fc-silent anti-CD2 monoclonal antibodies in allogeneic mixed lymphocyte reaction and autologous lymphocyte culture. Further, induction of NK cell fratricide and inhibition of natural cytotoxicity as well as antibody-dependent cytotoxicity by these agents were assessed. Blockade of CD2 via monoclonal antibodies in the absence of Fc γ receptor binding inhibited NK cell activation in allogeneic mixed lymphocyte reaction. In contrast, siplizumab increased NK cell activation in both mixed lymphocyte reaction and autologous lymphocyte culture due to FcγRIIIA binding. However, experiments using purified NK cells did not show an inhibitory effect of CD2 blockade on natural cytotoxicity or antibody-dependent cytotoxicity. Lastly, it was shown that siplizumab induces NK cell fratricide. Concluding, siplizumab is a promising biopharmaceutical drug candidate for depletion of T and NK cells with minimal off-target effects.

scholarly journals Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

1999 ◽  
Vol 190 (10) ◽  
pp. 1505-1516 ◽  
Author(s):  
Daniela Pende ◽  
Silvia Parolini ◽  
Anna Pessino ◽  
Simona Sivori ◽  
Raffaella Augugliaro ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Cell Activation ◽  
Nk Cell ◽  
Immunoglobulin Superfamily ◽  
Target Cells ◽  
Natural Cytotoxicity ◽  
Human Natural Killer Cells ◽  
Nk Cytotoxicity

Two major receptors involved in human natural cytotoxicity, NKp46 and NKp44, have recently been identified. However, experimental evidence suggested the existence of additional such receptor(s). In this study, by the generation of monoclonal antibodies (mAbs), we identified NKp30, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) cells. Although mAb-mediated cross-linking of NKp30 induces strong NK cell activation, mAb-mediated masking inhibits the NK cytotoxicity against normal or tumor target cells. NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK-mediated cytotoxicity against the majority of target cells, whereas it represents the major triggering receptor in the killing of certain tumors. This novel receptor is associated with CD3ζ chains that become tyrosine phosphorylated upon sodium pervanadate treatment of NK cells. Molecular cloning of NKp30 cDNA revealed a member of the immunoglobulin superfamily, characterized by a single V-type domain and a charged residue in the transmembrane portion. Moreover, we show that NKp30 is encoded by the previously identified 1C7 gene, for which the function and the cellular distribution of the putative product were not identified in previous studies.

scholarly journals Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands

2012 ◽  
Vol 9 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Michael Brusilovsky ◽  
Benyamin Rosental ◽  
Avishai Shemesh ◽  
Michael Y. Appel ◽  
Angel Porgador
Keyword(s):  
Nk Cell ◽  
Target Cells ◽  
Cell Recognition ◽  
Natural Cytotoxicity ◽  
Natural Cytotoxicity Receptors ◽  
Nk Cell Recognition

scholarly journals Altered Expression of Natural Cytotoxicity Receptors and NKG2D on Peripheral Blood NK Cell Subsets in Breast Cancer Patients

2016 ◽  
Vol 9 (5) ◽  
pp. 384-391 ◽  
Author(s):  
Nayeli Goreti Nieto-Velázquez ◽  
Yessica Dorin Torres-Ramos ◽  
José Luis Muñoz-Sánchez ◽  
Lorena Espinosa-Godoy ◽  
Susana Gómez-Cortés ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Nk Cell ◽  
Breast Cancer Patients ◽  
Natural Cytotoxicity ◽  
Altered Expression ◽  
Natural Cytotoxicity Receptors
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