scholarly journals Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responses

2003 ◽  
Vol 33 (11) ◽  
pp. 3101-3108 ◽  
Author(s):  
Karoline W. Schjetne ◽  
Hans T. Gundersen ◽  
Jens-Gustav Iversen ◽  
Keith M. Thompson ◽  
Bjarne Bogen
Keyword(s):  
T Cell ◽  
Chemokine Receptors ◽  
T Cell Responses ◽  
Antigen Presenting Cells ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Antigen Presenting

scholarly journals MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination

MedChemComm ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 138-148 ◽  
Author(s):  
Youhui Si ◽  
Yi Wen ◽  
Jianjun Chen ◽  
Rebecca R. Pompano ◽  
Huifang Han ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Signaling Pathways ◽  
T Cell Responses ◽  
Antigen Presenting Cells ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Self Assembled ◽  
Antigen Presenting

Self-assembled peptide nanofiber vaccines trigger redundant MyD88-dependent and MyD88-independent signaling pathways in APCs and T cells.

scholarly journals Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Hongyu Yu ◽  
Shaoyuan Cui ◽  
Yan Mei ◽  
Qinggang Li ◽  
Lingling Wu ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Mesangial Cells ◽  
T Cell Responses ◽  
Antigen Presenting Cells ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Antigen Presenting

Background. Mesangial cells play a prominent role in the development of inflammatory diseases and autoimmune disorders of the kidney. Mesangial cells perform the essential functions of helping to ensure that the glomerular structure is stable and regulating capillary flow, and activated mesangial cells acquire proinflammatory activities. We investigated whether activated mesangial cells display immune properties and control the development of T cell immunity. Methods. Flow cytometry analysis was used to study the expression of antigen-presenting cell surface markers and costimulatory molecules in mesangial cells. CD4+ T cell activation induced by mesangial cells was detected in terms of T cell proliferation and cytokine production. Results. IFN-γ-treated mesangial cells express membrane proteins involved in antigen presentation and T cell activation, including MHC-II, ICAM-1, CD40, and CD80. This finding suggests that activated mesangial cells can take up and present antigenic peptides to initiate CD4+ T cell responses and thus act as nonprofessional antigen-presenting cells. Polarization of naïve CD4+ T cells (Th0 cells) towards the Th1 phenotype was induced by coculture with activated mesangial cells, and the resulting Th1 cells showed increased mRNA and protein expression of inflammation-associated genes. Conclusion. Mesangial cells can present antigen and modulate CD4+ T lymphocyte proliferation and differentiation. Interactions between mesangial cells and T cells are essential for sustaining the inflammatory response in a variety of glomerulonephritides. Therefore, mesangial cells might participate in immune function in the kidney.

INFLUENCES OF ANTIGEN PRESENTING CELLS ON INJURY-INDUCED SKEWING OF CD4+ T-CELL RESPONSES

Shock ◽  
2006 ◽  
Vol 25 (Supplement 1) ◽  
pp. 50
Author(s):  
MP MacConmara ◽  
S Fujimi ◽  
A McKenna ◽  
PH Lapchack ◽  
A Delisle ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Antigen Presenting Cells ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Antigen Presenting
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