Fibronectin induces phosphorylation of a 120-kDa protein and synergizes with the T cell receptor to activate cytotoxic T cell clones

1995 ◽  
Vol 25 (1) ◽  
pp. 252-256 ◽  
Author(s):  
Hanne L. Ostergaard ◽  
Eileen A. Ma
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
T Cell Clones ◽  
Cell Clones

Preferential expression of a defined T-cell receptor β-chain gene in hapten-specific cytotoxic T-cell clones

Nature ◽  
1986 ◽  
Vol 322 (6077) ◽  
pp. 376-378 ◽  
Author(s):  
Ute Hochgeschwender ◽  
Hans Ulrich Weltzien ◽  
Klaus Eichmann ◽  
R. Bruce Wallace ◽  
Jörg T. Epplen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Chain Gene ◽  
T Cell Clones ◽  
Preferential Expression ◽  
Cell Clones ◽  
Β Chain

scholarly journals T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 ◽  
Vol 165 (3) ◽  
pp. 591-600 ◽  
Author(s):  
A Iwamoto ◽  
P S Ohashi ◽  
H Pircher ◽  
C L Walker ◽  
E E Michalopoulos ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Primary Structure ◽  
Cell Receptor ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Gene Products ◽  
T Cell Clones ◽  
Cell Clones ◽  
Variable Gene

The primary structure of the alpha and beta chains of the T cell antigen receptor in four cytotoxic T cell clones specific for N-iodoacetyl-sulfonic-naphthyl-ethylene-diamine (AED)-haptenated target cells displaying a particular class I MHC molecule has been determined. Two of the T cell clones, 8/10-2 and 5/10-20K, recognize AED-modified targets in association with H-2Kb, while the other two clones 5/10-20D and C9 react with AED-modified cells in the context of H-2Db. Comparison of the nucleotide sequences of both the alpha and beta chain cDNAs and their deduced protein sequences indicates that a specific variable gene segment was not used to recognize the hapten and/or class I gene products. Furthermore, there does not appear to be any conserved amino acid residues used in the AED-specific response other than the framework amino acids. However, when the two clones 8/10-2 and 5/10-20D were compared, a striking similarity was seen in the J segments. These two clones that recognize AED in the context of different MHC epitopes used identical J alpha (J alpha 810) and J beta (J beta 2.6) gene segments. C9, specific for AED-Db, shared identical V beta (V beta 6) and J beta gene segments (J beta 1.1) as those of a cytotoxic T cell that recognizes allogeneic targets expressing Db. These data indicate that a simple rule governing the usage of the variable regions of either the alpha or beta T cell receptor (TcR) genes in the recognition of antigen and MHC gene products cannot be formulated. However, subtle similarities can be detected in some situations between the primary structures of the TcR and the targets they recognize.

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

1983 ◽  
Vol 74 (1) ◽  
pp. 83-112 ◽  
Author(s):  
Ellis L. Reinherz ◽  
Stefan C. Meuer ◽  
Stuart F. Schlossman
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

Fine specificity and T-cell receptor ?-chain gene rearrangements of five H-2Db-specific cytotoxic T-cell clones

1987 ◽  
Vol 25 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Marco W. Schilham ◽  
Rosmarie Lang ◽  
Hans Acha-Orbea ◽  
Robbert Benner ◽  
Rolf Joho ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
T Cell Clones ◽  
Fine Specificity ◽  
Cell Clones ◽  
Receptor Chain

The expansion and selection of T cell receptor αβ intestinal intraepithelial T cell clones

1996 ◽  
Vol 26 (4) ◽  
pp. 914-921 ◽  
Author(s):  
Armelle Regnault ◽  
Jean-Pierre Levraud ◽  
Annick Lim ◽  
Adrien Six ◽  
Christiane Moreau ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Clones ◽  
Cell Clones ◽  
Selection Of

scholarly journals Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination

2016 ◽  
Vol 8 (332) ◽  
pp. 332ra46-332ra46 ◽  
Author(s):  
Qian Qi ◽  
Mary M. Cavanagh ◽  
Sabine Le Saux ◽  
Hong NamKoong ◽  
Chulwoo Kim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Chronic Infection ◽  
Cell Receptor ◽  
Control Mechanisms ◽  
Cell Repertoire ◽  
T Cell Clones ◽  
Varicella Zoster ◽  
Cell Clones

Diversity and size of the antigen-specific T cell receptor (TCR) repertoire are two critical determinants for successful control of chronic infection. Varicella zoster virus (VZV) that establishes latency during childhood can escape control mechanisms, in particular with increasing age. We examined the TCR diversity of VZV-reactive CD4 T cells in individuals older than 50 years by studying three identical twin pairs and three unrelated individuals before and after vaccination with live attenuated VZV. Although all individuals had a small number of dominant T cell clones, the breadth of the VZV-specific repertoire differed markedly. A genetic influence was seen for the sharing of individual TCR sequences from antigen-reactive cells but not for repertoire richness or the selection of dominant clones. VZV vaccination favored the expansion of infrequent VZV antigen–reactive TCRs, including those from naïve T cells with lesser boosting of dominant T cell clones. Thus, vaccination does not reinforce the in vivo selection that occurred during chronic infection but leads to a diversification of the VZV-reactive T cell repertoire. However, a single-booster immunization seems insufficient to establish new clonal dominance. Our results suggest that repertoire analysis of antigen-specific TCRs can be an important readout to assess whether a vaccination was able to generate memory cells in clonal sizes that are necessary for immune protection.

Sign in / Sign up

Export Citation Format

Share Document