Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids

1995 ◽  
Vol 25 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Bhanu Sinha ◽  
Jan Semmler ◽  
Tobias Eisenhut ◽  
Andreas Eigler ◽  
Stefan Endres
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Phosphodiesterase Inhibitors ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Necrosis Factor

scholarly journals Expression of thrombomodulin by smooth muscle cells in culture: different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture

Blood ◽  
1991 ◽  
Vol 77 (3) ◽  
pp. 515-518
Author(s):  
GA Soff ◽  
RW Jackman ◽  
RD Rosenberg
Keyword(s):  
Smooth Muscle ◽  
Blood Vessel ◽  
Smooth Muscle Cells ◽  
Vessel Wall ◽  
Tumor Necrosis ◽  
Cyclic Adenosine Monophosphate ◽  
Muscle Cells ◽  
Adenosine Monophosphate ◽  
Blood Vessel Wall ◽  
Necrosis Factor

Thrombomodulin (TM), a critical component of the protein C anticoagulant pathway, has previously been localized to endothelial cells (EC), but not smooth muscle cells (SMC) of the blood vessel wall. We demonstrate that cultured rat, bovine, as well as human SMC, but not blood vessel wall smooth muscle tissue, possess significant functional levels of TM and TM mRNA. Cyclic adenosine monophosphate stimulates TM expression in cultured SMC, but not EC, while tumor necrosis factor suppresses TM expression in EC but not cultured SMC. We postulate that following acute or chronic EC injury, luminal SMC can express TM, and are therefore able to protect the damaged blood vessel from thrombosis.

Sign in / Sign up

Export Citation Format

Share Document