Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: Comparison with oligonucleotide-driven amplification for evaluation of Vβ expression

1993 ◽  
Vol 23 (7) ◽  
pp. 1422-1429 ◽  
Author(s):  
Anita Diu ◽  
Francois Romagné ◽  
Catherine Genevée ◽  
Corinne Rocher ◽  
Jean-Michel Bruneau ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Variable Regions ◽  
Fine Specificity ◽  
Human T Cell

Monoclonal Antibodies to Human T - Cell Receptor Variable ? Regions

1995 ◽  
Vol 756 (1 T-Cell Recept) ◽  
pp. 106-109 ◽  
Author(s):  
A. NECKER ◽  
H. MICHALAKI ◽  
M. C. RAYNAL ◽  
C. ROCHER ◽  
A. DIU ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Variable Regions ◽  
Human T Cell

scholarly journals A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions.

1993 ◽  
Vol 90 (22) ◽  
pp. 10454-10458 ◽  
Author(s):  
M. F. Callan ◽  
H. T. Reyburn ◽  
P. Bowness ◽  
T. H. Ottenhoff ◽  
I. Engel ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Beta Chain ◽  
Variable Regions ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Receptor Beta

Generation of monoclonal antibodies against soluble human T cell receptor polypeptides

1991 ◽  
Vol 21 (9) ◽  
pp. 2111-2119 ◽  
Author(s):  
Brigitte Devaux ◽  
Pamela J. Bjorkman ◽  
Christine Stevenson ◽  
William Greif ◽  
John F. Ellio ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell

Generation of Monoclonal Antibodies Against a Human T Cell Receptor β Chain Expressed in Transgenic Mice

Hybridoma ◽  
1992 ◽  
Vol 11 (6) ◽  
pp. 701-713 ◽  
Author(s):  
JOANNE L. VINEY ◽  
HAYDN M. PROSSER ◽  
COLIN R.A. HEWITT ◽  
JONATHAN R. LAMB ◽  
MICHAEL J. OWEN
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
Β Chain

scholarly journals Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen.

1983 ◽  
Vol 158 (4) ◽  
pp. 1368-1373 ◽  
Author(s):  
O Acuto ◽  
S C Meuer ◽  
J C Hodgdon ◽  
S F Schlossman ◽  
E L Reinherz
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Beta Subunit ◽  
Beta Subunits ◽  
Two Dimensional ◽  
Variable Regions ◽  
Surface Receptors ◽  
Human T Cell ◽  
Peptide Maps

The T cell receptor for antigen (Ti) has recently been identified as a 90-kdalton T3-associated clonotypic structure composed of one 49-51-kdalton alpha and one 43-kdalton beta subunit, which are disulfide linked. Here, Ti molecules from two alloreactive CTL clones derived from the same donor but of differing specificities (CT8III and CT4II) are directly compared following isolation with anticlonotypic monoclonal antibodies. Isoelectric focusing shows that the alpha subunits (pI 4.4-4.7) are more acidic than the beta subunits (pI 6.0-6.2) but that each glycoprotein species is distinctive. More importantly, two-dimensional peptide maps of 125I-labeled surface receptors indicate that the beta chains of Ti1 and Ti2 appear unique and share only two peptides in common. In contrast, peptide maps of Ti1 and Ti2 alpha chains are more related although not identical. These results suggest that the human T cell receptor is composed of constant as well as variable regions and that at least one of the latter is located within the beta subunit.

The usage of variable regions of the human T cell receptor in patients with IgA nephropathy

Nephrology ◽  
1998 ◽  
Vol 4 (s1) ◽  
pp. A46-A46
Author(s):  
K MURO ◽  
M KOBAYASHI ◽  
M KONDOH ◽  
K YOH ◽  
K HIRAYAMA ◽  
...  
Keyword(s):  
T Cell ◽  
Iga Nephropathy ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Variable Regions ◽  
Human T Cell

Characterization of monoclonal antibodies specific for the Vβ3 family of the human T cell receptor generated using soluble TCR β-chain

1993 ◽  
Vol 164 (2) ◽  
pp. 233-244 ◽  
Author(s):  
Susan D. Calaman ◽  
Gerald R. Carson ◽  
Larry D. Henry ◽  
Jeffrey S. Kubinec ◽  
Rolf E. Kuestner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
Β Chain

scholarly journals A method for production of antibodies to human T-cell receptor beta-chain variable regions.

1991 ◽  
Vol 88 (19) ◽  
pp. 8357-8361 ◽  
Author(s):  
Y. W. Choi ◽  
B. Kotzin ◽  
J. Lafferty ◽  
J. White ◽  
M. Pigeon ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Beta Chain ◽  
Variable Regions ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Receptor Beta
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