Human peripheral blood γδ T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester

1993 ◽  
Vol 23 (2) ◽  
pp. 562-565 ◽  
Author(s):  
Klaus Pechhold ◽  
Dieter Kabelitz
Keyword(s):  
T Cells ◽  
Methyl Ester ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells ◽  
Lysosomotropic Agents

scholarly journals Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

Blood ◽  
2011 ◽  
Vol 118 (4) ◽  
pp. 992-1001 ◽  
Author(s):  
Daniel V. Correia ◽  
Manuela Fogli ◽  
Kelly Hudspeth ◽  
Maria Gomes da Silva ◽  
Domenico Mavilio ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Leukemia Cell ◽  
Γδ T Cells ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Recognition ◽  
Natural Cytotoxicity ◽  
Lymphoid Leukemia

Abstract The success of cancer immunotherapy depends on productive tumor cell recognition by killer lymphocytes. γδ T cells are a population of innate-like lymphocytes endowed with strong, MHC-unrestricted cytotoxicity against tumor cells. This notwithstanding, we recently showed that a large proportion of human hematologic tumors is resistant to γδ peripheral blood lymphocytes (PBLs) activated with specific agonists to the highly prevalent Vγ9Vδ2 TCR. Although this probably constitutes an important limitation to current γδ T cell–mediated immunotherapy strategies, we describe here the differentiation of a novel subset of Vδ2− Vδ1+ PBLs expressing natural cytotoxicity receptors (NCRs) that directly mediate killing of leukemia cell lines and chronic lymphocytic leukemia patient neoplastic cells. We show that Vδ1+ T cells can be selectively induced to express NKp30, NKp44 and NKp46, through a process that requires functional phosphatidylinositol 3-kinase (PI-3K)/AKT signaling on stimulation with γc cytokines and TCR agonists. The stable expression of NCRs is associated with high levels of granzyme B and enhanced cytotoxicity against lymphoid leukemia cells. Specific gain-of-function and loss-of-function experiments demonstrated that NKp30 makes the most important contribution to TCR-independent leukemia cell recognition. Thus, NKp30+ Vδ1+ T cells constitute a novel, inducible and specialized killer lymphocyte population with high potential for immunotherapy of human cancer.

scholarly journals Characterization of human peripheral blood γδ T cells in patients with sepsis

2020 ◽  
Author(s):  
Xiaohua Wang ◽  
Weijin Li ◽  
Dan Zhu ◽  
Hang Zhao ◽  
Pu Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells

Characteristics of Human Peripheral Blood γδ T Cells Expanded With Zoledronate

2021 ◽  
Vol 41 (12) ◽  
pp. 6031-6038
Author(s):  
MINSONG KIM ◽  
HYORI KIM ◽  
MINA HAN ◽  
HYUN JU HWANG ◽  
HYERY KIM ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells

Differentiation of Resting Human Peripheral Blood γδ T Cells toward Th1- or Th2-Phenotype

2001 ◽  
Vol 212 (2) ◽  
pp. 110-117 ◽  
Author(s):  
Daniela Wesch ◽  
Andrea Glatzel ◽  
Dieter Kabelitz
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells

Human peripheral blood γδ T cells respond to antigens of Plasmodium falciparum

1992 ◽  
Vol 4 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Martin Goodier ◽  
Petra Fey ◽  
Klaus Eichmann ◽  
Jean Langhorne
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells

scholarly journals Functional Expression of NOD2 in Freshly Isolated Human Peripheral Blood γδ T Cells

2011 ◽  
Vol 74 (2) ◽  
pp. 126-134 ◽  
Author(s):  
L. Marischen ◽  
D. Wesch ◽  
H.-H. Oberg ◽  
P. Rosenstiel ◽  
A. Trad ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells ◽  
Functional Expression

Neutrophil uptake of nitrogen-bisphosphonates leads to the suppression of human peripheral blood γδ T cells

2013 ◽  
Vol 71 (12) ◽  
pp. 2335-2346 ◽  
Author(s):  
Shirin Kalyan ◽  
Vijayanand Chandrasekaran ◽  
Elgar S. Quabius ◽  
Thisbe K. Lindhorst ◽  
Dieter Kabelitz
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Γδ T Cells
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