Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways

1991 ◽  
Vol 21 (11) ◽  
pp. 2877-2882 ◽  
Author(s):  
Claire Bihoreau ◽  
Agnès Heurtier ◽  
Alain Enjalbert ◽  
Nicole Corvaïa ◽  
Armand Bensussan ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
Adenylyl Cyclase ◽  
Cell Line ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Kinase C ◽  
Intracellular Pathways

Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

2002 ◽  
Vol 32 (3) ◽  
pp. 616 ◽  
Author(s):  
Charlotte Menné ◽  
Tine Møller Sørensen ◽  
Volkert Siersma ◽  
Marina von Essen ◽  
Niels Ødum ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Receptor ◽  
Rate Constants ◽  
Cell Receptor ◽  
Kinase C ◽  
Activated T Cell

scholarly journals T Cell Receptor-induced Phosphorylation of Sos Requires Activity of CD45, Lck, and Protein Kinase C, but Not ERK

1997 ◽  
Vol 272 (34) ◽  
pp. 21625-21634 ◽  
Author(s):  
Haoran Zhao ◽  
Yi-Yang Li ◽  
Raymond V. Fucini ◽  
Susan E. Ross ◽  
Jeffrey E. Pessin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Kinase C

Protein kinase C-activating phorbol esters augment expression of T cell receptor genes

1987 ◽  
Vol 17 (6) ◽  
pp. 803-807 ◽  
Author(s):  
Daniel J. Noonan ◽  
Noah Isakov ◽  
Argyrios N. Theofilopoulos ◽  
Frank J. Dixon ◽  
Amnon Altman
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Receptor ◽  
Phorbol Esters ◽  
Cell Receptor ◽  
Kinase C ◽  
T Cell Receptor Genes

scholarly journals Integrin-mediated Tyrosine Phosphorylation of Shc in T Cells Is Regulated by Protein Kinase C-dependent Phosphorylations of Lck

2003 ◽  
Vol 14 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Shi Niu ◽  
Haichun Xie ◽  
Eugene E. Marcantonio
Keyword(s):  
T Cells ◽  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
Tyrosine Phosphorylation ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
Cell Receptor ◽  
Serine Phosphorylation ◽  
Kinase C

Integrin receptor signals are costimulatory for mitogenesis with the T-cell receptor during T-cell activation. A subset of integrin receptors can link to the adapter protein Shc and provide a mitogenic stimulus. Using a combination of genetic and pharmacological approaches, we show herein that integrin signaling to Shc in T cells requires the receptor tyrosine phosphatase CD45, the Src family kinase member Lck, and protein kinase C. Our results suggest a model in which integrin-dependent serine phosphorylation of Lck is the critical step that determines the efficiency of Shc tyrosine phosphorylation in T cells. Serine phosphorylation of Lck is dependent on PKC and is also linked to CD45 dephosphorylation. Mutants of Lck that cannot be phosphorylated on the critical serine residues do not signal efficiently to Shc and have greatly reduced kinase activity. This signaling from integrins to Lck may be an important step in the costimulation with the T-cell receptor during lymphocyte activation.

T cell receptor α-chain tail is required for protein kinase C-mediated down-regulation, but not for signaling

1997 ◽  
Vol 27 (6) ◽  
pp. 1433-1441 ◽  
Author(s):  
B. Thomas Bäckström ◽  
Bent Rubin ◽  
Annick Peter ◽  
Georg Tiefenthaler ◽  
Ed Palmer
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Down Regulation ◽  
Kinase C ◽  
Α Chain

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

Cell ◽  
1988 ◽  
Vol 55 (1) ◽  
pp. 101-112 ◽  
Author(s):  
Viia E. Valge ◽  
Justin G.P. Wong ◽  
Barry M. Datlof ◽  
Anthony J. Sinskey ◽  
Anjana Rao
Keyword(s):  
T Cells ◽  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Receptor ◽  
Interleukin 2 ◽  
Cell Receptor ◽  
Receptor Ligands ◽  
Kinase C
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