Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases

1991 ◽  
Vol 21 (7) ◽  
pp. 1611-1621 ◽  
Author(s):  
Ranyang Huang ◽  
Thomas Blom ◽  
Lars Hellman
Keyword(s):  
Mast Cell ◽  
Structural Analysis ◽  
Serine Proteases ◽  
Mouse Mast Cell

scholarly journals Delayed Expulsion of the Nematode Trichinella spiralisIn Mice Lacking the Mucosal Mast Cell–Specific Granule Chymase, Mouse Mast Cell Protease-1

2000 ◽  
Vol 192 (12) ◽  
pp. 1849-1856 ◽  
Author(s):  
Pamela A. Knight ◽  
Steven H. Wright ◽  
Catherine E. Lawrence ◽  
Yvonne Y.W. Paterson ◽  
Hugh R.P. Miller
Keyword(s):  
Mast Cell ◽  
Serine Proteases ◽  
Trichinella Spiralis ◽  
Gastrointestinal Nematodes ◽  
Intestinal Lumen ◽  
Mucosal Mast Cell ◽  
Mast Cell Protease ◽  
Muscle Larvae ◽  
Mouse Mast Cell

Expulsion of gastrointestinal nematodes is associated with pronounced mucosal mast cell (MMC) hyperplasia, differentiation, and activation, accompanied by the systemic release of MMC granule chymases (chymotrypsin-like serine proteases). The β-chymase mouse mast cell protease-1 (mMCP-1) is expressed predominantly by intraepithelial MMCs, and levels in the bloodstream and intestinal lumen are maximal at the time of worm expulsion in parasitized mice. To address the in vivo functions of MMC-specific β-chymases, we have generated transgenic mice that lack the mMCP-1 gene. They were backcrossed onto a congenic BALB/c background to investigate the response to nematode infection. The deletion of the mMCP-1 gene is associated with significantly delayed expulsion of Trichinella spiralis and increased deposition of muscle larvae in BALB/c mice despite the presence of normal and sometimes increased numbers of MMCs. Neither worm fecundity nor worm burdens were altered in Nippostrongylus-infected mMCP-1−/− BALB/c mice. These data demonstrate, for the first time, that the ablation of an MMC-derived effector molecule compromises the expulsion process.

scholarly journals Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases.

1990 ◽  
Vol 87 (8) ◽  
pp. 3230-3234 ◽  
Author(s):  
D. S. Reynolds ◽  
R. L. Stevens ◽  
W. S. Lane ◽  
M. H. Carr ◽  
K. F. Austen ◽  
...  
Keyword(s):  
Mast Cell ◽  
Serine Proteases ◽  
Cell Populations ◽  
Mouse Mast Cell

scholarly journals Mouse Mast Cell Protease 9, a Novel Member of the Chromosome 14 Family of Serine Proteases that is Selectively Expressed in Uterine Mast Cells

1997 ◽  
Vol 272 (46) ◽  
pp. 29158-29166 ◽  
Author(s):  
John E. Hunt ◽  
Daniel S. Friend ◽  
Michael F. Gurish ◽  
Eric Feyfant ◽  
Andrej Šali ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Serine Proteases ◽  
Chromosome 14 ◽  
Mast Cell Protease ◽  
Mouse Mast Cell

scholarly journals Mouse Mast Cell Protease-4-dependent production of ET-1 (1-31) and of plaque progression in an/INS; Apolipoprotein E knock-out mouse model of spontaneous atherosclerosis

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e57
Author(s):  
Martin Houde ◽  
Walid Semaan ◽  
Louisane Desbiens ◽  
Zhipeng You ◽  
Adel G. Schwertani ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mouse Model ◽  
Apolipoprotein E ◽  
Plaque Progression ◽  
Knock Out ◽  
Mast Cell Protease ◽  
Mouse Mast Cell ◽  
Knock Out Mouse

scholarly journals Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase ofTrichinella spiralisInfection

2008 ◽  
Vol 180 (7) ◽  
pp. 4885-4891 ◽  
Author(s):  
Kichul Shin ◽  
Gerald F. M. Watts ◽  
Hans C. Oettgen ◽  
Daniel S. Friend ◽  
Alan D. Pemberton ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mast Cell ◽  
Chronic Phase ◽  
Mast Cell Tryptase ◽  
Mouse Mast Cell ◽  
Adaptive And Innate Immunity ◽  
Critical Link

Human mouse mast cell protease 7–like tryptase genes are pseudogenes

2001 ◽  
Vol 107 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Hae-Ki Min ◽  
Naotomo Kambe ◽  
Lawrence B. Schwartz
Keyword(s):  
Mast Cell ◽  
Mast Cell Protease ◽  
Mouse Mast Cell

scholarly journals Mouse Mast Cell Secretory Granules Can Function as Intracellular Ionic Oscillators

2001 ◽  
Vol 80 (5) ◽  
pp. 2133-2139 ◽  
Author(s):  
Ivan Quesada ◽  
Wei-Chun Chin ◽  
Jordan Steed ◽  
Patricia Campos-Bedolla ◽  
Pedro Verdugo
Keyword(s):  
Mast Cell ◽  
Secretory Granules ◽  
Mouse Mast Cell
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