Diversity in antigen recognition byMycobacterium tuberculosis-reactive T cell clones from the synovial fluid of rheumatoid arthritis patients

1991 ◽  
Vol 21 (5) ◽  
pp. 1297-1302 ◽  
Author(s):  
Pieter C. M. Res ◽  
Daniela L. M. Orsini ◽  
Jacob M. van Laar ◽  
Anneke A. M. Janson ◽  
Christiane Abou-Zeid ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Synovial Fluid ◽  
Antigen Recognition ◽  
T Cell Clones ◽  
Cell Clones

scholarly journals Isolation ofYERSINIA-Specific T Cell Clones from the Synovial Membrane and Synovial Fluid of a Patient with Reactive Arthritis

1991 ◽  
Vol 34 (9) ◽  
pp. 1151-1157 ◽  
Author(s):  
N. J. Viner ◽  
L. C. Bailey ◽  
P. F. Life ◽  
P. A. Bacon ◽  
J. S. H. Gaston
Keyword(s):  
T Cell ◽  
Synovial Fluid ◽  
Reactive Arthritis ◽  
Synovial Membrane ◽  
T Cell Clones ◽  
Cell Clones

Hapten-specific cytotoxic T cell clones undergo somatic variation of their antigen recognition specificity

1986 ◽  
Vol 16 (6) ◽  
pp. 631-639 ◽  
Author(s):  
Hans Ulrich Weltzien ◽  
Bettina Kempkes ◽  
Dragana L. Jankovic ◽  
Klaus Eichmann
Keyword(s):  
T Cell ◽  
Antigen Recognition ◽  
Cytotoxic T Cell ◽  
Somatic Variation ◽  
T Cell Clones ◽  
Recognition Specificity ◽  
Cell Clones

Salmonella-reactive Synovial Fluid T-cell Clones in a Patient with Post-infectious Salmonella Arthritis

1990 ◽  
Vol 19 (5) ◽  
pp. 350-355 ◽  
Author(s):  
E. Hermann ◽  
W.-J. Mayet ◽  
T. Poralla ◽  
K.-H. Meyer Zum Büschenfelde ◽  
B. Fleischer
Keyword(s):  
T Cell ◽  
Synovial Fluid ◽  
T Cell Clones ◽  
Cell Clones ◽  
Post Infectious

scholarly journals Recognition of a mycobacteria-specific epitope in the 65-kD heat-shock protein by synovial fluid-derived T cell clones.

1990 ◽  
Vol 171 (3) ◽  
pp. 831-841 ◽  
Author(s):  
J S Gaston ◽  
P F Life ◽  
P J Jenner ◽  
M J Colston ◽  
P A Bacon
Keyword(s):  
Amino Acids ◽  
T Cell ◽  
Heat Shock ◽  
Synovial Fluid ◽  
Heat Shock Protein ◽  
Mononuclear Cells ◽  
Cell Clone ◽  
T Cell Clones ◽  
Cell Clones ◽  
T Cell Clone

Adjuvant arthritis in rats is induced by a T cell clone specific for amino acids 180-188 of the mycobacterial 65-kD heat-shock protein, and synovial T cell responses to this same Ag have been noted in human arthritis. We have isolated 65-kD Ag-specific T cell clones from synovial fluid mononuclear cells of a patient with acute arthritis, which, unlike the corresponding PBMC, showed a marked proliferative response to the 65-kD Ag. Using synthetic peptides corresponding to the whole sequence of the 65-kD Ag, all the clones were shown to recognize an epitope present in the first NH2-terminal peptide (amino acids 1-15), with no response to the adjacent peptide (amino acids 6-22) or to any other peptide. The complete dominance of this epitope in the response to the 65-kD Ag was shown by documenting responses to the peptide in PBMC obtained after recovery from the arthritis. This epitope, like that recognized by the rat arthritogenic T cell clone, is in a portion of the 65-kD sequence that is not conserved between bacteria and eukaryotes, so that in this case, joint inflammation could not be attributed to bacteria-induced T cell clones cross-reacting with the self 65-kD Ag.

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