Subclinical thyroid disease and heart failure

2014 ◽  
Vol 16 (2) ◽  
pp. 119-121 ◽  
Author(s):  
Annemieke Roos ◽  
Thera P. Links ◽  
Bruce H. R. Wolffenbuttel
Keyword(s):  
Heart Failure ◽  
Thyroid Disease

scholarly journals Impact of Thyroid Disease on Heart Failure

10.5772/66283 ◽  
2017 ◽  
Author(s):  
Adina Elena Stanciu ◽  
Adina Zamfir-Chiru-Anton ◽  
Marcel Marian Stanciu ◽  
Dan Cristian Gheorghe
Keyword(s):  
Heart Failure ◽  
Thyroid Disease

scholarly journals Fatal Cardiothyreosis Revealed Through A Status Epilepticus And Resulting In A Therapeutic Impasse - A Case Report

2015 ◽  
Vol 2 (2) ◽  
pp. 47-48
Author(s):  
Abdelilah Ghannam ◽  
Zakaria Ouassou ◽  
Jawad Tadili ◽  
Ali Kettani ◽  
Mamoun Faroudy
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Case Report ◽  
Status Epilepticus ◽  
Clinical Picture ◽  
Thyroid Disease ◽  
Late Diagnosis ◽  
Therapeutic Management ◽  
Therapeutic Impasse

Cardiothyreosis is a rare and serious complication of thyroid disease. We report a case that is unique in its inaugural clinical picture (status epilepticus) due to late diagnosis and iatrogenic drug which precipitated the patient in an array of congestive heart failure where therapeutic management was limited by insufficient technical facilities leading to death.

scholarly journals SUN-409 Subclinical Hypothyroidism in Hospitalized Patients with Chronic Heart-Failure or Chronic Renal-Failure Is Most Probably Not Due to Thyroid Disease

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Amir Bashkin ◽  
Wagde Abu Saleh ◽  
Ohad Ronen
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Chronic Heart Failure ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Disease ◽  
Final Analysis ◽  
Hospitalized Patients ◽  
Normal Range

Abstract Introduction: Subclinical hypothyroidism is common in chronic diseases such as heart failure and advanced chronic renal failure. It is unclear whether this is a thyroid disease or an isolated TSH elevation. The goal of this study was to investigate the prevalence of worsening thyroid function in these patients with recurrent admissions. Methods: We performed a retrospective review of medical records of hospitalized patients in non-surgical wards from 2013–2016. First, all patients with TSH levels above the normal range (4.95 mIU/L) and up to 12 mIU/L with FT4 levels in the normal range were identified. We then investigated which of these patients were re-hospitalized at least once within at least six months. According to data from the re-hospitalization, an increase in TSH level above 12 mIU/L or initiation of levothyroxine treatment was defined as worsening of thyroid function. Patients treated with a drug affecting thyroid function or with a known thyroid disease prior to first hospitalization were excluded from the study. Chronic heart failure and chronic renal failure were determined according to reported diagnosis and drug treatment. Chronic renal failure patients were included if the glomerular filtration rate (GFR) in the first hospitalization was below 30 ml/min/1.72 square meter. Results: Overall, 90,199 TSH tests were sent from the non-surgical wards, most of them as part of the admissions profile. Of these, 2,116 hospitalizations met the inclusion criteria of the first hospitalization. In the final analysis, 126 inpatients with at least one re-hospitalization were included, of whom 43 (34.1%) had chronic heart failure and 22 (17.5%) had chronic renal failure. According to the most recent re-hospitalization, thyroid function was worse in 11(8.7%), 4 (9.3%) and 2 (9.1%) patients of the total, heart failure and renal failure groups respectively. The TSH level was found to be normal in re-hospitalization in 81.4% of those with heart failure and 86.4% of those with renal-failure. No association between heart failure or renal-failure and thyroid function worsening was found (p = 1.00 for both). Of 34 patients with chronic heart failure re-hospitalized after 1/2-1 year, in 29 (85.3%) the repeated TSH was normal, in 3 (8.8%) it was unchanged and in 2 (5.9%) it was worse. In most re-hospitalization the worsening was due to initiation of Levothyroxin treatment and because of the retrospective nature of the study we cannot be sure whether the initiation was justified; therefore, it is likely that the worsening percentage is even lower. Conclusions: An isolated TSH elevation in hospitalized patients with past medical history of chronic heart-failure or chronic renal failure does not indicate thyroid disease, in most cases.

scholarly journals PERANCANGAN BUKU PANDUAN INTERAKTIF MENGENAI PENGENALAN PENYAKIT GANGGUAN KELENJAR TIROID PADA ANAK-ANAK

2018 ◽  
Vol 2 (1) ◽  
pp. 40
Author(s):  
DENISE KEMAS ◽  
ELIZABETH WIANTO ◽  
MIKI TJANDRA
Keyword(s):  
Mental Health ◽  
Heart Failure ◽  
Thyroid Gland ◽  
Thyroid Disease ◽  
Healthy Lifestyle ◽  
Communication Strategy ◽  
Thyroid Disorder ◽  
Healthy Foods ◽  
Keywords Children ◽  
Parents And Children

The danger of thyroid disease disorder can be suffered by anyone, including in children aged 7 to 12 years old. If not treated immediately, this disease can have a fatal impact of heart failure, prominent eyes, mental health, and sterility, even to a coma. This happens because of a lack of knowledge about the thyroid gland, its illness and its dangerous effect, which leads to less information given to the children about the disorder. The aim of this design of this interactive guidebook is so that parents and children can know and start tackling about the thyroid gland as well as the dangers of this disease and want to start a healthy lifestyle, by starting to eat healthy foods for the thyroid gland. Visual communication strategy used is to create an educative and interactive guidebook. Supported by supporting media, such as: workbook, promotion media that is booth, leaflet, poster, website and gimmick. The final goal of the design is that parents and children can recognize the thyroid gland and maintain their health by eating a healthy diet and live a healthy lifestyle. Keywords:  children; guidebook; interactive; thyroid disorder

scholarly journals Subclinical hypothyroidism or isolated high TSH in hospitalized patients with chronic heart-failure and chronic renal-failure

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amir Bashkin ◽  
Wagde Abu Saleh ◽  
Mona Shehadeh ◽  
Lea Even ◽  
Ohad Ronen
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Retrospective Study ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Low Dose ◽  
Hospitalized Patients ◽  
Inclusion Criteria ◽  
And Gender ◽  
Levothyroxine Treatment

AbstractSub-clinical hypothyroidism (SCH) is common in heart failure (HF) and advanced renal failure (RF), but it is unclear whether there is a thyroid disease or a transient increase in TSH level. This is a retrospective study of hospitalized patients in medical departments. All patients with SCH and a TSH level up to less than 12 mIU/L were identified. Those who had at least one recurring admission within at least 6 months were included. A change in thyroid function during the last re-admission was determined and classified as an improvement, no change, or worsening of thyroid function. Overall, 126 cases of SCH met the inclusion criteria for re-admission. Analysis of the most recent hospitalization showed that in 100 (79.4%) patients thyroid function improved, in 15 (11.9%) patients thyroid function remained unchanged and only in 11 (8.7%) patients did thyroid function worsen. In most cases, worsening of hypothyroidism was determined by initiation of a low dose levothyroxine treatment. Of the 126 participants, 43 (34.1%) and 22 (17.5%) had a diagnosis of HF and RF (CKD stages 4 and 5), respectively. There was no association between HF or advanced RF and worsening of SCH. No association was found between worsening of hypothyroidism and gender, age, TSH, or creatinine levels in the first hospitalization. A borderline association between elevated CRP levels at first hospitalization and hypothyroidism worsening was found (p = 0.066). Mildly elevated TSH in hospitalized patients with HF and advanced RF is transient and most probably not related to thyroid disease and not associated with age or gender.

Mitochondria in Cardiomyopathy: Alterations in Size, Number and Internal Structures

1968 ◽  
Vol 26 ◽  
pp. 126-127
Author(s):  
George Hug ◽  
William K. Schubert
Keyword(s):  
Heart Failure ◽  
Biochemical Analysis ◽  
Left Ventricular ◽  
Size Number ◽  
Internal Structures ◽  
Left Ventricular Outflow ◽  
Chest X Ray ◽  
Myocardial Fibers ◽  
Muscle Biopsies ◽  
Needle Liver Biopsy

A white boy six months of age was hospitalized with respiratory distress and congestive heart failure. Control of the heart failure was achieved but marked cardiomegaly, moderate hepatomegaly, and minimal muscular weakness persisted.At birth a chest x-ray had been taken because of rapid breathing and jaundice and showed the heart to be of normal size. Clinical studies included: EKG which showed biventricular hypertrophy, needle liver biopsy which showed toxic hepatitis, and cardiac catheterization which showed no obstruction to left ventricular outflow. Liver and muscle biopsies revealed no biochemical or histological evidence of type II glycogexiosis (Pompe's disease). At thoracotomy, 14 milligrams of left ventricular muscle were removed. Total phosphorylase activity in the biopsy specimen was normal by biochemical analysis as was the degree of phosphorylase activation. By light microscopy, vacuoles and fine granules were seen in practically all myocardial fibers. The fibers were not hypertrophic. The endocardium was not thickened excluding endocardial fibroelastosis. Based on these findings, the diagnosis of idiopathic non-obstructive cardiomyopathy was made.

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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