Reply: Epicardial adipose tissue: does it mediate the cardio‐protective effects of SGLT‐2 inhibitors in subjects with heart failure?

2022 ◽  
Author(s):  
Nicolò De Biase ◽  
Lavinia Del Punta ◽  
Nicola Riccardo Pugliese
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Protective Effects

scholarly journals EPICARDIAL ADIPOSE TISSUE EVALUATED BY CARDIAC MAGNETIC RESONANCE PREDICTS ADVERSE OUTCOMES IN HEART FAILURE PATIENTS

2020 ◽  
Vol 75 (11) ◽  
pp. 1080
Author(s):  
Reza Mohebi ◽  
Carlos Santos-Gallego ◽  
Darian de Luna ◽  
Kenny Daici ◽  
Juan Antonio Requena Ibanez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Epicardial Adipose Tissue ◽  
Adverse Outcomes ◽  
Heart Failure Patients

scholarly journals Hemodynamic and Functional Impact of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction

2020 ◽  
Vol 8 (8) ◽  
pp. 657-666
Author(s):  
Katlyn E. Koepp ◽  
Masaru Obokata ◽  
Yogesh N.V. Reddy ◽  
Thomas P. Olson ◽  
Barry A. Borlaug
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Ejection Fraction ◽  
Epicardial Adipose Tissue ◽  
Preserved Ejection Fraction ◽  
Functional Impact

scholarly journals Epicardial adipose tissue in patients with heart failure

2010 ◽  
Vol 12 (1) ◽  
Author(s):  
Christina Doesch ◽  
Dariusch Haghi ◽  
Stephan Flüchter ◽  
Tim Suselbeck ◽  
Stefan O Schoenberg ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Patients With Heart Failure

scholarly journals Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

2016 ◽  
Vol 310 (7) ◽  
pp. E550-E564 ◽  
Author(s):  
Ana Burgeiro ◽  
Amelia Fuhrmann ◽  
Sam Cherian ◽  
Daniel Espinoza ◽  
Ivana Jarak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Glucose Uptake ◽  
Epicardial Adipose Tissue ◽  
Heart Failure Patients ◽  
Fat Depots ◽  
Glucose And Lipid Metabolism

Type 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes. Epicardial adipose tissue surrounding the heart displays biochemical, thermogenic, and cardioprotective properties. However, the metabolic cross-talk between epicardial fat and the myocardium is largely unknown. This study sought to understand epicardial adipose tissue metabolism from heart failure patients with or without diabetes. We aimed to unravel possible differences in glucose and lipid metabolism between human epicardial and subcutaneous adipocytes and elucidate the potential underlying mechanisms involved in heart failure. Insulin-stimulated [14C]glucose uptake and isoproterenol-stimulated lipolysis were measured in isolated epicardial and subcutaneous adipocytes. The expression of genes involved in glucose and lipid metabolism was analyzed by reverse transcription-polymerase chain reaction in adipocytes. In addition, epicardial and subcutaneous fatty acid composition was analyzed by high-resolution proton nuclear magnetic resonance spectroscopy. The difference between basal and insulin conditions in glucose uptake was significantly decreased ( P = 0.006) in epicardial compared with subcutaneous adipocytes. Moreover, a significant ( P < 0.001) decrease in the isoproterenol-stimulated lipolysis was also observed when the two fat depots were compared, and it was strongly correlated with lipolysis, lipid storage, and inflammation-related gene expression. Moreover, the fatty acid composition of these tissues was significantly altered by diabetes. These results emphasize potential metabolic differences between both fat depots in the presence of heart failure and highlight epicardial fat as a possible therapeutic target in situ in the cardiac microenvironment.

scholarly journals Expression Profile of Circular RNAs in Epicardial Adipose Tissue in Heart Failure

2019 ◽  
Author(s):  
Meili Zheng ◽  
Lei Zhao ◽  
Xinchun Yang
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Expression Profile ◽  
Epicardial Adipose Tissue ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Circular Rna ◽  
Circular Rnas ◽  
Artery Disease ◽  
Pathway Analyses

AbstractRecent studies have reported circular RNA (circRNA) expression profiles in various tissue types; specifically, a recent work showed a detailed circRNA expression landscape in the heart. However, circRNA expression profile in human epicardial adipose tissue (EAT) remains undefined. RNA-sequencing was carried out to compare circRNA expression patterns in EAT specimens from coronary artery disease (CAD) cases between the heart failure (HF) and non-HF groups. The top highly expressed EAT circRNAs corresponded to genes involved in cell proliferation and inflammatory response, including KIAA0182, RHOBTB3, HIPK3, UBXN7, PCMTD1, N4BP2L2, CFLAR, EPB41L2, FCHO2, FNDC3B and SPECC1. Among the 141 circRNAs substantially different between the HF and non-HF groups (P<0.05;fold change>2), hsa_circ_0005565 stood out, and was mostly associated with positive regulation of metabolic processes and insulin resistancein GO and KEGG pathway analyses, respectively. These data indicate EAT circRNAs contribute to the pathogenesis of metabolic disorders causing HF.

scholarly journals Epicardial Adipose Tissue Measured From Computed Tomography Predicts Cardiac Resynchronization Therapy Response in Patients With Non-ischemic Systolic Heart Failure

2021 ◽  
Vol 8 ◽  
Author(s):  
Hui-yuan Qin ◽  
Cheng Wang ◽  
Duo-duo Qian ◽  
Chang Cui ◽  
Ming-long Chen
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Regression Analysis ◽  
Epicardial Adipose Tissue ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Qrs Duration ◽  
Response Group ◽  
Crt Response

Background: Epicardial adipose tissue (EAT) has been linked with the pathogenesis of heart failure (HF). Limited data have been reported about the clinical value of EAT for cardiac resynchronization therapy (CRT) in non-ischemic systolic HF. We aimed to explore the values of EAT measured from CT to predict the response to CRT in patients with non-ischemic systolic HF.Methods: Forty-one patients with CRT were consecutively recruited for our study. All patients received both gated resting Single Photon Emission CT (SPECT) myocardial perfusion imaging (MPI) and dual-source multi-detector row CT scans. EAT thickness was assessed on both the parasternal short and horizontal long-axis views. The area of EAT was calculated at the left main coronary artery level. Left ventricular systolic mechanical dyssynchrony (LVMD) was measured by phase standard deviation (PSD) and phase histogram bandwidth (PBW). The definition of CRT response was an improvement of 5% in left ventricular ejection fraction (LVEF) at 6 months after CRT implantation.Results: After 6 months of follow-up, 58.5% (24 of 41) of patients responded to CRT. A greater total perfusion deficit (TPD) was observed in the left ventricle, and a narrower QRS complex was observed in the nonresponse group than in the response group (p &lt; 0.05). Meanwhile, the systolic PSD and systolic PBW were statistically greater in the CRT group with no response than in the response group (p &lt; 0.05). Meanwhile, the baseline QRS duration, TPD, systolic PSD, systolic PBW, EAT thicknesses of the left ventricular (LV) apex, right atrioventricular (AV) groove, and left AV groove were all significantly related to the CRT response in the univariate logistic regression analysis. Furthermore, the QRS duration and EAT thicknesses of the right AV groove and left AV groove were independent predictors of CRT response in the multivariate logistic regression analysis.Conclusions: The EAT thickness of the left AV groove in patients with non-ischemic systolic HF is associated with the TPD of LV and LV systolic dyssynchrony. The EAT thickness of the AV groove has a good predictive value for the CRT response in patients with non-ischemic systolic HF.

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